Pre-invasive cervical disease and uterine cervical cancer in Brazilian adolescents: prevalence and related factors

Monteiro, Denise Leite Maia; Trajano, Alexandre J. B.; Silva, Kátia Silveira da; Russomano, Fábio Bastos

doi:10.1590/s0102-311x2006001200004

Cited by 13 publications

(17 citation statements)

References 28 publications

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“…[6][7][8][9] Mulheres pertencentes às faixas etárias mais jovens (18-24 anos) foram as que menos realizaram o exame ginecológi-co como o Papanicolaou alguma vez na vida e nos últimos três anos, concordando com o observado por outros autores. 5,6,8,[10][11][12] Apesar de considerar a faixa etária de 25-59 anos como priori- [13][14][15][16][17][18] A justificativa seria de que, embora a história natural do câncer do colo do útero seja caracterizada pela evolução lenta, lesões precursoras estão sendo detectadas com mais frequência entre adolescentes e nesse grupo etário parecem progredir mais rapidamente. Deve-se também à crescente incidência de lesões pré--neoplásicas em idades cada vez menores e aumento nas lesões de alto grau entre mulheres jovens que iniciam atividade sexual durante a adolescência e com diferentes parceiros sexuais.…”

Section: Discussionunclassified

Factors associated with non-performance of papanicolaou tests in Belo Horizonte

Lage¹,

Pessoa²,

Velasquez-Melendez³

2013

Reme: Revista Mineira De Enfermagem

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RESUMOBuscou-se estimar os fatores associados à não realização do exame de Papanicolaou no município de Belo Horizonte, Minas Gerais, entre mulheres de 18-65 anos, durante o ano de 2008. Trata-se de um estudo transversal, de base populacional, utilizando-se dados de inquérito realizado por entrevistas telefônicas para monitorar a frequência e a distribuição de fatores de risco e proteção para doenças crônicas não transmissíveis -VIGITEL 2008. Foram consideradas informações de 1.214 mulheres. Utilizou-se a regressão de Poisson para verificar a associação entre a não realização do exame de Papanicolaou com as variáveis independentes. A frequência de realização do exame entre as mulheres foi de 76,43% (IC 95%: 69,30). Ser jovem; possuir baixa escolaridade; viver sem companheiro; não ter realizado o exame de mamografia; declarar como ruim o estado de saúde; e não possuir diagnóstico médico de hipertensão mostraram associação independente com a não realização do teste. A prevalência do exame em Belo Horizonte foi satisfatória, porém insuficiente para impactar no perfil epidemiológico do câncer do colo uterino. É preciso fortalecer e qualificar as ações de promoção da saúde necessárias para mais adesão das mulheres que não estão realizando o exame de Papanicolaou. Palavras-chave: Neoplasias do Colo do Útero; Esfregaço Vaginal; Monitoramento. (IC 95%: 69,30 ABSTR ACT

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Section: Discussionunclassified

Factors associated with non-performance of papanicolaou tests in Belo Horizonte

Lage¹,

Pessoa²,

Velasquez-Melendez³

2013

Reme: Revista Mineira De Enfermagem

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“…The health of this group is extremely vulnerable to such things as unplanned pregnancies with their attendant complications and the increased prevalence of high grade cervical squamous intraepithelial lesions, which suggest the necessity for sexually active adolescents to be included in cervical cancer screening programs. 12 Moreover, they are at high risk of sexually transmitted disease which can lead to gynecological problems which, if not properly dealt with, may affect the future fertility of these young people. 7 It is necessary that healthcare services fulfi ll their obligations to fully care for this population in order to minimize the occurrence of these complications.…”

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confidence: 99%

Consulta ginecológica sob a ótica de estudantes do ensino médio do Rio de Janeiro, RJ

2013

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OBJECTIVE:To analyze sociocultural differences and perceptions of gynecological consultations for high school girls. METHODS:A transversal study with 418 high school girls from three schools of different profi les in the city of Rio de Janeiro, Southeastern Brazil, in 2010. A structured questionnaire encompassing socio-demographic characteristics, sexual behavior and evaluation of gynecological consultations was completed. Yates' Chi-square test and the Student's t-test were utilized adopting a value of p < 0.05. RESULTS:The students of private and federal public schools presented similar profi les but both were different from the state school girls. The latter had lower socioeconomic status, and their parents had lower levels of education, the predominance of afro-descendants was observed, as were a larger number of sexual partners, pregnancy and cases of sexual violence. The average age of menarche and sexarche among the students were similar, but the fi rst gynecological consultation was signifi cantly later among the state school students. The majority showed some knowledge of contraception and STDs, although only a minority received guidance from the consultations. Students expressed the desire that the professionals dedicate more time, patience and availability to them during consultations. CONCLUSIONS:The provision of gynecological services for teenagers is not satisfactory, according to the teenagers' evaluations. Users of the private health system have gynecological consultations earlier than those who only have access to the public system. It is necessary to create mechanisms that facilitate access and adhesion to a routine of gynecological prevention for this age group.

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“…Worldwide, approximately 470,000 new cases are encountered annually, with about 80% of these cases reported from developing countries (Monteiro et al, 2006, Pettersson et al, 2010. Most cervical cancer cases belong to one of two histological lineages, based on whether they emerge in the squamous or glandular cervical epithelium.…”

Section: Cervical Cancermentioning

confidence: 99%

“…Most cervical cancer cases belong to one of two histological lineages, based on whether they emerge in the squamous or glandular cervical epithelium. About 80% of the cases are squamous cell carcinomas (SCCs) whereas the remaining 20% are glandular malignancies (adenocarcinomas) (Badaracco et al, 2010, Duenas-Gonzalez et al, 2010, Monteiro et al, 2006, Pettersson et al, 2010. HPV remains the main cause of cervical cancer accounting for about 99.7% of cases; most of these case are caused by the high-risk HPV types 16 and 18 (Beaudenon and Huibregtse, 2008).…”

Section: Cervical Cancermentioning

confidence: 99%

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siRNA screening of the kinome identified Aurora A kinase as a therapeutic target gene in cervical cancer

Bokhari¹

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HPV oncogenes disable a number of tumour suppressor pathways, including p53 and Rb, contributing to the transformed phenotype. Loss of these critical host cell functions may also provide an opportunity to selectively target the destruction of HPV-transformed cells. We have performed an siRNA screen using the kinome (779 genes) library to identify genes that when depleted are synthetically lethal with HPV transformation. The primary and validations screens have confirmed Aurora A kinase (AURKA) as a potential synthetic lethal target selective for HPV transformed cells. AURKA has been further investigated using the selective small molecule inhibitor MLN8237. We found that MLN8237 was significantly more potent towards the HPV transformed cells. The effect was not a consequence of targeting mitosis as two other mitotic inhibitors, PLK1 inhibitor (BI2536) and taxol, demonstrated no selectivity. Analysis of the nuclear structure and DNA content showed that Aurora A inhibition promoted a high level of polyploidy in non-HPV treated cells whilst this same degree of polyploidy was associate with apoptosis in the HPV-transformed cell lines. Whereas Bcl-2 over expression in HeLa cells had no effect on sensitivity to MLN8237, Mcl-1 overexpressing HeLa cells were less sensitive to the MLN8237 in comparison to the parental cell line, which may suggests the involvement of Noxa or Puma proapoptotic proteins in the induction of the apoptosis in the HPV-transformed cells. The transfection of the non-HPV C33A cervical cancer and SCC25 squamous cell carcinoma cell lines with the HPV16 oncogenic E7 increased sensitivity to MLN8237 between 3 >10 fold suggesting that the sensitivity to MLN8237-dependent killing was a direct consequence of HPV E7 expression.Xenograft experiments with cervical cancer cell lines in immunodeficient mice showed MLN8237 inhibited growth of HPV and non-HPV xenografts during treatment with 30mg/kg MLN8237 once a day for 10 consecutive days. However, outgrowth of tumour was noticed from the second day post-treatment in the non-HPV tumour group whereas the HPV-induced tumour group did not show cancer recurrence for 50 days post-treatment. These findings suggest that MLN8237 represent a promising novel therapeutic targeted agent against HPV-transformed cervical cancer.iii

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Pre-invasive cervical disease and uterine cervical cancer in Brazilian adolescents: prevalence and related factors

Cited by 13 publications

References 28 publications

Factors associated with non-performance of papanicolaou tests in Belo Horizonte

Factors associated with non-performance of papanicolaou tests in Belo Horizonte

Consulta ginecológica sob a ótica de estudantes do ensino médio do Rio de Janeiro, RJ

siRNA screening of the kinome identified Aurora A kinase as a therapeutic target gene in cervical cancer

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