Pre- and Post-Transcriptional Regulation of cFLIP for Effective Cancer Therapy Using pH-Ultrasensitive Nanoparticles

Phung, Cao Dai; Tran, Tuan Hiep; Choi, Ju-Yeon; Jeong, Jee‐Heon; Ku, Sae Kwang; Yong, Chul Soon; Kim, Jong Oh

doi:10.1021/acsami.0c20624

Cited by 13 publications

(10 citation statements)

References 35 publications

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“…The acidic TME is an important feature of cancer [ 32 , 33 ]. Previous studies indicated that MnO 2 response to acidic TME leading to release of Mn 2+ according to chemical equation: MnO 2 + 2H + → Mn 2+ + H 2 O + 1/2O 2 ↑ [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy

Zhao

Pan

Zou

et al. 2023

Bioactive Materials

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Section: Resultsmentioning

confidence: 99%

Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy

Zhao

Pan

Zou

et al. 2023

Bioactive Materials

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“…After that, these samples were incubated with biotinylated universal secondary antibody and ABC reagents for 1 h at room temperature in a humidity chamber. The areas occupied by positive cells (%/mm 2 of tumor mass) and the mean numbers of positive cells (cells/mm 2 of tumor mass) were measured by a histological camera system and automated image analyzer as in the previous report 46 …”

Section: Methodsmentioning

confidence: 99%

Shaping the “hot” immunogenic tumor microenvironment by nanoparticles co‐delivering oncolytic peptide and TGF‐β1 siRNA for boosting checkpoint blockade therapy

Phung

Nguyen

Jeong

et al. 2022

Bioengineering & Transla Med

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Induction of potent immune responses toward tumors remains challenging in cancer immunotherapy, in which it only showed benefits in a minority of patients with “hot” tumors, which possess pre‐existing effector immune cells within the tumor. In this study, we proposed a nanoparticle‐based strategy to fire up the “cold” tumor by upregulating the components associated with T and NK cell recruitment and activation and suppressing TGF‐β1 secretion by tumor cells. Specifically, LTX‐315, a first‐in‐class oncolytic cationic peptide, and TGF‐β1 siRNA were co‐entrapped in a polymer‐lipid hybrid nanoparticle comprising PLGA, DSPE‐mPEG, and DSPE‐PEG‐conjugated with cRGD peptide (LTX/siR‐NPs). The LTX/siR‐NPs showed significant inhibition of TGF‐β1 expression, induction of type I interferon release, and triggering immunogenic cell death (ICD) in treated tumor cells, indicated via the increased levels of danger molecules, an in vitro setting. The in vivo data showed that the LTX/siR‐NPs could effectively protect the LTX‐315 peptide from degradation in serum, which highly accumulated in tumor tissue. Consequently, the LTX/siR‐NPs robustly suppressed TGF‐β1 production by tumor cells and created an immunologically active tumor with high infiltration of antitumor effector immune cells. As a result, the combination of LTX/siR‐NP treatment with NKG2A checkpoint inhibitor therapy remarkably increased numbers of CD8+NKG2D+ and NK1.1+NKG2D+ within tumor masses, and importantly, inhibited the tumor growth and prolonged survival rate of treated mice. Taken together, this study suggests the potential of the LTX/siR‐NPs for inflaming the “cold” tumor for potentiating the efficacy of cancer immunotherapy.

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Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

“…Additionally, the silanol groups on the surface of MSNs could be modified by various organic functional groups through covalent bonds, such as NH 2 and COOH. 280,281 Wagner et al 282 reported multifunctional nanocarriers (MSN-Ph in -avidin out ) based on core-shell MSNs. The core of the MSNs was functionalized with phenyl to accommodate hydrophobic R848, and the outer surface was functionalized with carboxyl groups to allow continuous modification to attach a pHresponsive acetal linker and a biotin-avidin complex for enhancing anticancer effects with immune reaction.…”

Section: Nonmetallic Nanoparticlesmentioning

confidence: 99%

“…These modification strategies of coating realized cellular targeting and photodynamic cancer therapy based on multifunctional MSNs nanoparticles. Additionally, the silanol groups on the surface of MSNs could be modified by various organic functional groups through covalent bonds, such as NH 2 and COOH 280,281 . Wagner et al 282 .…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

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Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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Pre- and Post-Transcriptional Regulation of cFLIP for Effective Cancer Therapy Using pH-Ultrasensitive Nanoparticles

Cited by 13 publications

References 35 publications

Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy

Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy

Shaping the “hot” immunogenic tumor microenvironment by nanoparticles co‐delivering oncolytic peptide and TGF‐β1 siRNA for boosting checkpoint blockade therapy

Multifunctional nanoparticle for cancer therapy

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