Pre‐ and Perinatal Complications and “Childhood Schizophrenia”: A Comparison of Five Controlled Studies*

Pollack, Max; Woerner, Margaret G.

doi:10.1111/j.1469-7610.1966.tb02249.x

Cited by 30 publications

(7 citation statements)

References 17 publications

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“…However, diagnostic uncertainty about the classification of childhood psychosis seems to have halted research in this area. Even though a review in 1966 concluded that "the need for further research…is strongly indicated by these findings" (7), there was a gap of 10 years before a study by Torrey and colleagues (8) reported an association between bleeding in pregnancy and childhood psychosis.…”

mentioning

confidence: 97%

Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review

Cannon

Jones²,

Murray

2002

AJP

983

664

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Current methods of investigating the relationship between obstetric complications and schizophrenia are reaching the limit of their usefulness. Lack of statistical power to measure small and interactive effects and lack of detailed information about the prenatal period are major problems with current approaches. A combination of disciplines and approaches will be needed to elucidate the mechanisms underlying these small but important associations.

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mentioning

confidence: 97%

Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review

Cannon

Jones²,

Murray

2002

AJP

983

664

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“…Lane and Albee (54) also reported lower birth weights for schizophrenics as compared with controls. Finally there is ample evidence of pregnancy and perinatal difficulties as well as prematurity in connection with mental illness in childhood (50,65,66,111).…”

Section: Findings In Psychotic Childrenmentioning

confidence: 99%

The Evoked Potential in Pharmacopsychiatry

Saletu¹

1977

Neuropsychobiology

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Somatosensory, visual and auditory evoked potentials (EP) were recorded in different psychiatric populations before as well as during psychotropic drug treatment. Drug-free schizophrenic patients showed shorter latencies, smaller amplitudes and an increased intraindividual variability in their EP than controls. Psychotic children but also children of schizophrenic mothers (so-called high-risk children) exhibited similar differences as compared to controls, suggesting a CNS overarousal as the pathoneurophysiological sub-strate of schizophrenia. Shorter latencies were also seen in children of psychopathic fathers. Regression and correlation analysis of psychopathological and EP measurements in hyperkinetic children revealed the following findings: the shorter the latencies and the higher the amplitudes, the sicker was the child. During psychopharmacotherapy, significant changes occurred in the EP measurements, which were found to be significantly correlated with clinical improvement or deterioration. Neuroleptics induced a latency increase and an amplitude decrease in schizophrenic patients and psychotic children. Interestingly, amphetamine produced in hyperkinetic children a latency increase too, thus explaining the ‘paradoxical’ clinical response to amphetamine observed in these children. Differences between therapy-responsive and therapy-resistant patients are described and, finally, some data concerning the role of the pretreatment EP as a predictor of therapeutic outcome are discussed.

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“…Also, a review of the literature has found that a large portion of schizophrenics have a history of head trauma [23]. Several authors have noted an association between perinatal distress and schizophrenia similar to the asso ciation noted for head trauma and schizophrenia [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…Scientific studies indicate that several variables are valid prognostic indicators for psychosis [1][2][3][4][5][6][7], Several authors have noted an association be tween perinatal distress and the occurrence of schizo phrenia [8][9][10][11], yet little research has been done to assess the significance of perinatal trauma as a prognostic indi cator.…”

Section: Introductionmentioning

confidence: 99%

Perinatal Distress and Prognosis of Psychotic Illness

Wilcox

Nasrallah

1987

Neuropsychobiology

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The medical histories of a group of 511 patients hospitalized for schizophrenia were examined for the occurrence of perinatal distress. These patients were part of a 40-year follow-up study, so that their prognostic outcome was known at the time of this study. In this way, 200 cases of chronic schizophrenia were compared with 311 cases of psychotics with good prognosis. It was found that a history of perinatal distress was much more common in the poor prognosis group than in the good prognosis group. This difference could not be accounted for by age or family history of psychiatric illness.

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Pre‐ and Perinatal Complications and “Childhood Schizophrenia”: A Comparison of Five Controlled Studies*

Cited by 30 publications

References 17 publications

Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review

Obstetric Complications and Schizophrenia: Historical and Meta-Analytic Review

The Evoked Potential in Pharmacopsychiatry

Perinatal Distress and Prognosis of Psychotic Illness

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