2022
DOI: 10.1016/j.intimp.2022.109282
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Pramipexole and Lactoferrin ameliorate Cyclophosphamide-Induced haemorrhagic cystitis via targeting Sphk1/S1P/MAPK, TLR-4/NF-κB, and NLRP3/caspase-1/IL-1β signalling pathways and modulating the Nrf2/HO-1 pathway

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Cited by 10 publications
(7 citation statements)
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“…This effect is achieved through the inhibition of NLRP3 inflammasome activation and regulation of the NF-κB signaling pathway, both of which are closely linked to toll-like receptors (TLRs). Additionally, GA promotes the upregulation of nuclear factor E2-related factor 2 (Nrf2) and concurrently lowers the production of reactive oxygen species (ROS). ,, In addition, immunofluorescence detection using corresponding antibodies to label macrophages with M1 pro-inflammatory phenotype or M2 anti-inflammatory phenotype is conducive to exploring the inflammatory state . Although a decrease in M1 phenotype and an increase in M2 phenotype have been observed in numerous anti-inflammatory studies involving GA, recent studies suggest that GA may be involved in inhibition of M2 phenotype to alleviate tissue fibrosis. The anti-inflammatory effects of GA-PEPE are likely due to its antioxidant polyphenol structure and its targeting of the TLR anti-inflammatory pathway.…”
Section: Resultsmentioning
confidence: 99%
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“…This effect is achieved through the inhibition of NLRP3 inflammasome activation and regulation of the NF-κB signaling pathway, both of which are closely linked to toll-like receptors (TLRs). Additionally, GA promotes the upregulation of nuclear factor E2-related factor 2 (Nrf2) and concurrently lowers the production of reactive oxygen species (ROS). ,, In addition, immunofluorescence detection using corresponding antibodies to label macrophages with M1 pro-inflammatory phenotype or M2 anti-inflammatory phenotype is conducive to exploring the inflammatory state . Although a decrease in M1 phenotype and an increase in M2 phenotype have been observed in numerous anti-inflammatory studies involving GA, recent studies suggest that GA may be involved in inhibition of M2 phenotype to alleviate tissue fibrosis. The anti-inflammatory effects of GA-PEPE are likely due to its antioxidant polyphenol structure and its targeting of the TLR anti-inflammatory pathway.…”
Section: Resultsmentioning
confidence: 99%
“…Additionally, GA promotes the upregulation of nuclear factor E2-related factor 2 (Nrf2) and concurrently lowers the production of reactive oxygen species (ROS). 50 , 77 , 85 87 In addition, immunofluorescence detection using corresponding antibodies to label macrophages with M1 pro-inflammatory phenotype or M2 anti-inflammatory phenotype is conducive to exploring the inflammatory state. 88 Although a decrease in M1 phenotype and an increase in M2 phenotype have been observed in numerous anti-inflammatory studies involving GA, recent studies suggest that GA may be involved in inhibition of M2 phenotype to alleviate tissue fibrosis.…”
Section: Resultsmentioning
confidence: 99%
“…55 We have previously reported a close correlation between the induction of ROS-derived liver lipoperoxidation and the appearance of preneoplastic lesions. 38 On the other hand, the antioxidant potential of bLf has been widely documented; 52,56,57 however, it has been mostly attributed to the iron sequestering capability of native- or apo-bLf, since iron is a well-known pro-oxidant that induces ROS production through the Fenton reaction. 58 Therefore, we verified that iron-saturated bLf did not increase ROS production beyond the increase produced by DEN.…”
Section: Discussionmentioning
confidence: 99%
“…The SphK1/S1P/NF-κB signaling pathway is implicated in the regulation of inflammation in different diseases, such as spinal cord injury, acute liver failure, and haemorrhagic cystitis. [38][39][40] Inactivation of SphK1/S1P/NF-κB pathway by diacerein leads to suppression of apoptosis and oxidative stress in an LPS-induced rat model of acute lung injury. 41 It is worth noting that resveratrol inhibited LPS-mediated inflammation and fibronectin expression in rat glomerular mesangial cells by blocking the SphK1/S1P/NF-κB pathway.…”
Section: Discussionmentioning
confidence: 99%