PP.05.01

Abstract

Objective: Non-alcoholic fatty liver disease (NAFLD) is often associated with metabolic syndrome (MS). MS promotes arterial stiffness and is associated with abnormal BP diurnal variations. Ambulatory monitoring (AM) of central blood pressure (BP) and arterial stiffness parameters is a new method that extends understanding of the characteristics of BP and arterial properties. The aim of the study was to explore characteristics of central pulse wave and AIx on brachial and central BP AM in hypertensive subjects with non-alcoholic fatty liver disease (NAFLD). Design and method:The study included 30 untreated non-diabetic hypertensive patients with NAFLD (diagnosed according to ASSLD Practice Guidelines, 2012) and metabolic syndrome (47% men, 51,3 ± 4,2 years, 50% of smokers, BMI 31,3 ± 2,2 kg/m2, clinical BP 163,4 ± 12,5/102,6 ± 9,7 mm Hg). The effects on 24h, day-and night-time brachial and central BP were evaluated with oscillometric BPLab VASOTENS system (OOO Petr Telegin, Nizhniy Novgorod, Russia).Objective: To study of the relationship of overweight and hemodynamic echocardiographic indices of cardiac activity study in hypertensive patients. Design and method:Participants are 112 patients with hypertension of II degree, aged 30-65 years. The average age of the patients was 54,5 (CI 52,3; 56,8) years. Following criteria were taken into account: age, systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), height, weight, body mass index (BMI), waist and hips circumference indicators (WCI, HCI), the ratio WCI/HCI. Following parameters during echocardiography were studied: left ventricle end-diastolic dimension (LVEDD), interventricular septum thickness (IVST) and left ventricular posterior wall (LVPW), an index of relative wall thickness (RWT) and left ventricular myocardial mass (LVM) and the left ventricular mass index (LVMI). "STATISTICA" software was used for statistical processing.Results: 95% confidence interval was applied. SBP was 150.4 (145,8; 155,0); DBP -90.