Objectives: Kidney transplantation (KTx) may improve arterial stiffness. The purpose of the present study is to examine the effects of KTx on aortic stiffness after 2 years of follow-up. Method: In this prospective, longitudinal observational study, we studied hemodynamic parameters prior to KTx and 3, 6 and 24 months after a KTx in 59 dialysis patients. Aortic stiffness was measured by carotid-femoral pulse wave velocity (cf-PWV) and heart rate adjusted central augmentation index (AIx) was measured by arterial tonometry. A successful KTx was defined by an estimated eGFR of !45 mL/min/1.73m2. Linear mixed model was used to take into account the repeated measures of aortic stiffness and mean blood pressure. Values are reported as meanAESEM Results: The mean age was 48 years, with 70% male, 20% with cardiovascular disease and 25% diabetes. After adjusting for mean blood pressure, cf-PWV decreased significantly from 11.2AE0.33 to 10.3AE0.30 by 3 months (PZ0.042), but cf-PWV gradually increased to 10.8AE0.31 and 11.2AE0.33 (m/s) by 6 and 24 months and was not statistically different from the baseline. In an analysis stratified by age, the early improvement of aortic stiffness was only statistically significant for patients older than 50 years of age. However, MBP-adjusted AIx did not change significantly after KTx. Conclusion: This study shows that there is an early reduction in aortic stiffness after KTx with a gradual return in aortic stiffness to baseline values after 2 years of follow-up. This study suggests a reduction in the rate of progression of aortic stiffness after KTx.
respectively. SBP/DBP was greatly reduced by 31.9/15.5 mmHg in those patients without regularly prior treatment. Among them, mean SBP reduction of 34.8mmHg was presented in subjects who achieved BP goal. Single-pill combination of Aml/Val was well tolerated in the study patients. The adverse events(AEs) were reported in 13.9 % of participants. The majority of AEs were reported as mild or moderate in severity. Conclusions:This study showed that single-pill combination of Aml/Val resulted in clinically and statistically significant additional BP reduction in Taiwanese hypertensive patients inadequately controlled with antihypertensive monotherapy. The safety profile and patient's tolerability is also documented. Moreover, use of Aml/Val has been shown to significantly lower total health care costs compared with free Aml/Val combination therapy.Objective: We decided to study the effectiveness of combinations that are included in the list of the most commonly prescribed in Ukraine.
Objectives: Kidney transplantation (KTx) may improve arterial stiffness. The purpose of the present study is to examine the effects of KTx on aortic stiffness after 2 years of follow-up. Method: In this prospective, longitudinal observational study, we studied hemodynamic parameters prior to KTx and 3, 6 and 24 months after a KTx in 59 dialysis patients. Aortic stiffness was measured by carotid-femoral pulse wave velocity (cf-PWV) and heart rate adjusted central augmentation index (AIx) was measured by arterial tonometry. A successful KTx was defined by an estimated eGFR of !45 mL/min/1.73m2. Linear mixed model was used to take into account the repeated measures of aortic stiffness and mean blood pressure. Values are reported as meanAESEM Results: The mean age was 48 years, with 70% male, 20% with cardiovascular disease and 25% diabetes. After adjusting for mean blood pressure, cf-PWV decreased significantly from 11.2AE0.33 to 10.3AE0.30 by 3 months (PZ0.042), but cf-PWV gradually increased to 10.8AE0.31 and 11.2AE0.33 (m/s) by 6 and 24 months and was not statistically different from the baseline. In an analysis stratified by age, the early improvement of aortic stiffness was only statistically significant for patients older than 50 years of age. However, MBP-adjusted AIx did not change significantly after KTx. Conclusion: This study shows that there is an early reduction in aortic stiffness after KTx with a gradual return in aortic stiffness to baseline values after 2 years of follow-up. This study suggests a reduction in the rate of progression of aortic stiffness after KTx.
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