Power spectrum analysis of ultrasonic vocalization elicited by maternal separation in rat pups

Ise, Satoko; Ohta, Hisashi

doi:10.1016/j.brainres.2009.06.003

Cited by 22 publications

(33 citation statements)

References 17 publications

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“…The former might be equivalent to our type 2 class, which is also characterized by short duration and higher peak frequency, together with rather small bandwidth, a measure which was not addressed by Harmon et al (). Recently, Boulanger‐Bertolus, Rincón‐Cortés, Sullivan, and Mouly (), who used a different behavioral testing procedure, reported two types of USV (see also Ise & Ohta, for SD pups) in isolated male and female LE pups around PND 12–15: One type, termed “40‐kHz calls,” had mean frequencies around 40 kHz and long call durations (around 140 ms), whereas the other, “66‐kHz calls,” was higher (around 66 kHz) and much shorter (around 21 ms). These features are very similar to our present type 1 and type 2 calls, respectively, which supports the validity of our results.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, defining subtypes is of scientific importance, and they can also help to measure the effects of pre-or neonatal manipulations (Tonkiss et al, 2003, Barren & Gilbertson 2005, Ise & Ohta, 2009, Krüger & Hanganu-Opatz, 2012, Blazevic, Merkler, Persic, & Hranilovic, 2017. However, there is no consensus yet, how many types one should differentiate and by which means.…”

Section: Stock Differences In Call Typesmentioning

confidence: 99%

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Isolation‐induced ultrasonic vocalizations in pups: A comparison between Long‐Evans, Sprague–Dawley, and Wistar rats

Schwarting

Wöhr

2018

Developmental Psychobiology

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Rat pup ultrasonic vocalizations (USV) are usually studied in outbred rats belonging to either Long-Evans, Sprague-Dawley, or Wistar stocks, but these were not compared so far. We therefore performed a stock comparison and analyzed USV of male pups (postnatal day 11) belonging to these three stocks. Pups of all three stocks showed substantial isolation-induced USV, but differed in various call features, like call numbers, peak frequency, and frequency modulation. Also, three different call types were identified by means of a quantitative approach based on peak frequency and frequency modulation, and it was found that their proportions differed between stocks. These results are discussed with respect to functional aspects of pup USV.

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Section: Discussionmentioning

confidence: 99%

Section: Stock Differences In Call Typesmentioning

confidence: 99%

Isolation‐induced ultrasonic vocalizations in pups: A comparison between Long‐Evans, Sprague–Dawley, and Wistar rats

Schwarting

Wöhr

2018

Developmental Psychobiology

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“…Traditionally, two types of USVs have been studied in laboratory rodents as measures of internal states: pup isolation calls (Branchi, Santucci, & Alleva, 2001; Brudzynski, Kehoe, & Callahan, 1999; D'Amato, Scalera, Sarli, & Moles, 2005; Elwood & Keeling, 1982; Hahn, Hewitt, Adams, & Trully, 1987; Hofer & Shair, 1992; Ise & Ohta, 2009; Noirot & Pye, 1969; Sales & Smith, 1978; Wöhr, Dalhoff, et al, 2008a) and adult USVs in aversive or rewarding conditions (Brudzynski, 2007; 2009; Burgdorf et al, 2007; Knutson, Burgdorf, & Panksepp, 2002; Wöhr, Houx, et al, 2008b). Reliable elicitation of isolation calls by quantifiable stimuli and a well characterized developmental trajectory have made pup USVs a useful tool for testing the effects of anxiogenic or anxiolytic compounds (Dirks et al, 2002; Fish, Faccidomo, Gupta, & Miczek, 2004; Fish, Sekinda, Ferrari, Dirks, & Miczek, 2000) and for phenotyping mouse models of neuropsychiatric disorders associated with deficits in vocal communication (Scattoni, Crawley, & Ricceri, 2009).…”

Section: Introductionmentioning

confidence: 99%

Mouse vocal communication system: Are ultrasounds learned or innate?

2013

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Mouse ultrasonic vocalizations (USVs) are often used as behavioral readouts of internal states, to measure effects of social and pharmacological manipulations, and for behavioral phenotyping of mouse models for neuropsychiatric and neurodegenerative disorders. However, little is known about the neurobiological mechanisms of rodent USV production. Here we discuss the available data to assess whether male mouse song behavior and the supporting brain circuits resemble those of known vocal non-learning or vocal learning species. Recent neurobiology studies have demonstrated that the mouse USV brain system includes motor cortex and striatal regions, and that the vocal motor cortex sends a direct sparse projection to the brainstem vocal motor nucleus ambiguous, a projection thought be unique to humans among mammals. Recent behavioral studies have reported opposing conclusions on mouse vocal plasticity, including vocal ontogeny changes in USVs over early development that might not be explained by innate maturation processes, evidence for and against a role for auditory feedback in developing and maintaining normal mouse USVs, and evidence for and against limited vocal imitation of song pitch. To reconcile these findings, we suggest that the trait of vocal learning may not be dichotomous but encompass a broad set of behavioral and neural traits we call the continuum hypothesis, and that mice possess some of the traits associated with a capacity for limited vocal learning.

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“…For example, rat pups emit ultrasonic vocalizations (USV) when they are separated from the dam (Portfors, 2007;Ise and Ohta, 2009;Schwarting and Wöhr, 2012). The dam approaches the pups in response to their USVs, retrieves them, and returns them to the nest (Schwarting and Wöhr, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Subsequently, USVs decreased and then completely disappeared around PND 21, when pups were able to wean (Schwarting and Wöhr, 2012). USVs in rat pups have been shown to be at frequencies of approximately 40 kHz and durations of approximately 80-150 ms (Portfors, 2007;Ise and Ohta, 2009;Schwarting and Wöhr, 2012). Because 40-kHz USVs in rat pups were demonstrated to be emitted upon maternal separation, USVs were considered to express the pups' distress state (Brudzynski et al, 1999;Portfors, 2007).…”

Section: Introductionmentioning

confidence: 99%

Acoustic alterations of ultrasonic vocalization in rat pups induced by perinatal hypothyroidism

Wada

2017

NeuroToxicology

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Perinatal hypothyroidism causes serious damage to auditory functions that are essential for vocalization development. In rat pups, perinatal hypothyroidism potentially affects the development of ultrasonic vocalization (USV) as a result of hearing deficits. This study examined the effect of perinatal hypothyroidism on the development of USVs in rat pups. Twelve pregnant rats were divided into three groups and treated with the anti-thyroid drug methimazole (MMI) via drinking water, from gestational day 15 to postnatal day (PND) 21. The MMI concentration (w/v) was 0% (control group), 0.01% (low-dose group), or 0.015% (high-dose group). After birth, the pups were individually separated from the dam and littermates on PNDs 5, 10, 15, and 20, and their USVs were recorded for 5min. On PNDs 5 and 10, compared with the control group, the low- and high-dose groups exhibited reductions of both frequency-modulated and downward USVs. On PND 15, however, the low- and high-dose groups displayed increases in number, duration, and amplitude of USVs compared with those in the control group. Lower body weights were observed for the low- and high-dose groups than for the control group. Total thyroxine concentrations in plasma were dose-dependently reduced. The onset of auditory functions appeared on PNDs 11-14. Thus, the rat pups were unable to hear externally produced USVs before PND 11. USVs emitted on PNDs 5 and 10 might have been spontaneous and independent of the pups' own or littermate-emitted USVs. The developmental retardation of vocalization-related organs or muscles might underlie the acoustic alterations of USVs on PNDs 5 and 10. The greater number, duration, and amplitude of USVs on PND 15, after which the hearing onset occurred, suggested that the elevation of auditory thresholds occurred as a result of hearing deficits in the low- and high-dose groups. Perinatal hypothyroidism appears to have caused acoustic alterations in the USV development.

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Power spectrum analysis of ultrasonic vocalization elicited by maternal separation in rat pups

Cited by 22 publications

References 17 publications

Isolation‐induced ultrasonic vocalizations in pups: A comparison between Long‐Evans, Sprague–Dawley, and Wistar rats

Isolation‐induced ultrasonic vocalizations in pups: A comparison between Long‐Evans, Sprague–Dawley, and Wistar rats

Mouse vocal communication system: Are ultrasounds learned or innate?

Acoustic alterations of ultrasonic vocalization in rat pups induced by perinatal hypothyroidism

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