Povidone-iodine-functionalized fluorinated copolymers with dual-functional antibacterial and antifouling activities

Borjihan, Qinggele; Yang, Jiebing; Song, Qing; Gao, Lingling; Xu, Miao; Gao, Tianyi; Liu, Wenxin; Li, Peng; Li, Quanshun; Dong, Alideertu

doi:10.1039/c9bm00583h

Cited by 43 publications

(30 citation statements)

References 66 publications

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“…All these FTIR characteristic peaks fully demonstrated the successful combination of PAN, DCDMH, and GO into the fiber system through the one-step electrospinning strategy. 6A) exhibited two main peaks, C 1s and N 1s, indicating the PAN was made up of elemental carbon and nitrogen [46]. The appearance of C 1s at 284 eV and N 1s at 398 eV thus marks the existence of PAN as the support matrix for DCDMH and GO loading.…”

Section: Resultsmentioning

confidence: 94%

“…Figure 6 presents XPS survey scans, showing the C 1s spectrum, O 1s spectrum, N 1s spectrum, and Cl 2p spectrum of (A) PAN, (B) PAN/GO, (C) PAN/DCDMH, and (D) PAN/GO/DCDMH. The pristine PAN ( Figure 6 A) exhibited two main peaks, C 1s and N 1s, indicating the PAN was made up of elemental carbon and nitrogen [ 46 ]. The appearance of C 1s at 284 eV and N 1s at 398 eV thus marks the existence of PAN as the support matrix for DCDMH and GO loading.…”

Section: Resultsmentioning

confidence: 99%

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An N-Halamine/Graphene Oxide-Functionalized Electrospun Polymer Membrane That Inactivates Bacteria on Contact and by Releasing Active Chlorine

Lan

Zhang

et al. 2021

Polymers

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The emergence of antibiotic-resistant “superbugs” in recent decades has led to widespread illness and death and is a major ongoing public health issue. Since traditional antimicrobials and antibiotics are in many cases showing limited or no effectiveness in fighting some emerging pathogens, there is an urgent need to develop and explore novel antibacterial agents that are both powerful and reliable. Combining two or more antibiotics or antimicrobials has become a hot topic in antibacterial research. In this contribution, we report on using a simple electrospinning technique to create an N-halamine/graphene oxide-modified polymer membrane with excellent antibacterial activity. With the assistance of advanced techniques, the as-obtained membrane was characterized in terms of its chemical composition, morphology, size, and the presence of active chlorine. Its antibacterial properties were tested with Escherichia coli (E. coli) as the model bacteria, using the colony-counting method. Interestingly, the final N-halamine/graphene oxide-based antibacterial fibrous membrane inactivated E. coli both on contact and by releasing active chlorine. We believe that the synergistic antimicrobial action of our as-fabricated fibrous membrane should have great potential for utilization in water disinfection, air purification, medical and healthcare products, textile products, and other antibacterial-associated fields.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

An N-Halamine/Graphene Oxide-Functionalized Electrospun Polymer Membrane That Inactivates Bacteria on Contact and by Releasing Active Chlorine

Lan

Zhang

et al. 2021

Polymers

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“…Therefore, new technologies are greatly demanded to solve the above‐mentioned disadvantages. So far, researchers have witnessed the advancement of antimicrobial polymer coatings to prevent microorganisms' adhesion and proliferation for combating BAI, by various approaches such as self‐assembly interactions, in situ surface immobilization, chemical vapor deposition, and plasma‐assisted surface grafting . However, the preparation of these coatings usually involves complicated steps, expensive materials, or harsh water/oxygen‐free environment .…”

Section: Methodsmentioning

confidence: 99%

Mussel‐Inspired, Surface‐Attachable Initiator for Grafting of Antimicrobial and Antifouling Hydrogels

Feng

et al. 2019

Macromol. Rapid Commun.

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In this work, a novel biomimetic surface‐attachable initiator is successfully synthesized by the conjugation of 3,4‐dihydroxyphenylacetic acid and thermal 2,2′‐azobis(2‐methylpropionamide) dihydrochloride (V‐50). The synthesized initiator (DOPV) can adhere to various material surfaces in a mussel‐inspired way and initiate the surface grafting polymerization. Hydrogel coatings are facilely prepared by the thermal‐initiated radical copolymerization of antimicrobial polyhexamethylene guanidine and antifouling polyethylene glycol oligomers. The developed hydrogel coatings not only show antimicrobial activity toward gram‐negative and gram‐positive bacteria but also demonstrate protein resistance, antibiofilm efficacy, hemocompatibility, and low cytotoxicity in vitro. Most importantly, the hydrogel coatings reveal excellent antimicrobial efficacy with a log reduction above 5 in a rodent subcutaneous infection model. These results demonstrate the potential fabrication of bio‐functional coatings for biomedical devices or implants through an inexpensive, facile, and environmentally friendly mussel‐inspired technique.

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“…Owing to a large number of infections and associated economic losses stemming from bacterial adhesion and fouling, the development and discovery of novel bacterial antifouling surfaces is a topic receiving increasing attention from scientists and researchers [27][28][29][30][31][32][33][34][35][36][37]. While various applications of helicenes have been reported before, no prior work, to the best of our knowledge, has focused on the interactions of bacteria with helicene films.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Antifouling Characteristics of Helicene—Graphene Films

Liu

Bae

et al. 2021

Nanomaterials

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Herein, we describe interfacially-assembled [7]helicene films that were deposited on graphene monolayer using the Langmuir-Schaefer deposition by utilizing the interactions of nonplanar (helicene) and planar (graphene) π–π interactions as functional antifouling coatings. Bacterial adhesion of Staphylococcus aureus on helicene—graphene films was noticeably lower than that on bare graphene, up to 96.8% reductions in bacterial adhesion. The promising bacterial antifouling characteristics of helicene films was attributed to the unique molecular geometry of helicene, i.e., nano-helix, which can hinder the nanoscale bacterial docking processes on a surface. We envision that helicene—graphene films may eventually be used as protective coatings against bacterial antifouling on the electronic components of clinical and biomedical devices.

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Povidone-iodine-functionalized fluorinated copolymers with dual-functional antibacterial and antifouling activities

Abstract: Povidone-iodine-functionalized fluorinated polymer coatings with dual-functional antibacterial and antifouling activities should be very promising in practical biomedical applications.

Cited by 43 publications

References 66 publications

An N-Halamine/Graphene Oxide-Functionalized Electrospun Polymer Membrane That Inactivates Bacteria on Contact and by Releasing Active Chlorine

An N-Halamine/Graphene Oxide-Functionalized Electrospun Polymer Membrane That Inactivates Bacteria on Contact and by Releasing Active Chlorine

Mussel‐Inspired, Surface‐Attachable Initiator for Grafting of Antimicrobial and Antifouling Hydrogels

Bacterial Antifouling Characteristics of Helicene—Graphene Films

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