Potentiometric Flow Injection Analysis of Bromhexine Hydrochloride and its Pharmaceutical Preparation Using Conventional and Coated Wire Ion-Selective Electrodes

Abstract

Bromhexine hydrochloridei on-selectivee lectrodes (conventionalt ype)b ased on bromhexinium tetraphenylb orate( I) andb romhexinium-phosphotungstate (II) were prepared.T he electrodes exhibitedm ean slopes of calibration graphs of 59.4 mV and 59.8 mV per decade of bromhexine concentrationa t2 5 Cf or electrode (I) and (II),r espectively.B oth electrodes couldb eu sed within the concentrationr ange 3.16x10-5 -1.00x10 -2 Mb romhexine within the pH range 2.0-4.5. The standard electrodes potentials were determined at different temperatures and used to calculate the isothermal coefficients of the electrodes, which were 0.00065 and 0.00050V C -1 for (I) and (II), respectively. The electrodes showed av ery good selectivity for bromhexine with respect to an umber of inorganic cations, amino acids and sugars. The electrodes were applied to the potentiometric determination of bromhexine hydrochloride and its pharmaceutical preparationu nder batch and flow injection conditions.G raphite, copper and silver coated wires were prepared, characterized and successfully applied as sensors for the drug under investigation. KeywordsIon-selectivee lectrodes, bromhexine hydrochloride, conventional andc oated wire electrodes,flowinjection analysis andconductimetry.Scientia Pharmaceutica (Sci. Pharm.) 74, 121-135

CFIA-ISNAG fluorimeter for the Determination of Bromhexine-HCl in Drugs via the Measurement Scattered Light at ± 90˚

“…Furthermore, BH-HCl is one of the mucous-modifying drugs that aid expectoration by improving the flow characteristics of bronchial mucous [3,4]. A literature review indicated the determination of bromhexine hydrochloride in dosage form, either in combined form or alone, by spectrophotometric [5][6][7][8][9][10][11], potentiometric [12], voltammetric [13], colorimetric [14], chemiluminescence [15,16], TLC [17], HPLC [18][19][20][21][22][23][24][25], RRLC-MS/MS [26], and HPTLC-HPLC [27]. This study presents a new method to determine BH-HCl in pharmaceutical formulations using tetraphenylborate as a precipitating reagent to form a yellowish-white precipitate with the use of a homemade instrument.…”

New microextraction methods for the evaluation of bromhexine HCl in pure and pharmacological formulations.

“…Assisting vasomotor secretion generates a vasomotor secretory effect [5]. Several analytical techniques were used to estimate bromohexine HCl in medicinal formulations such as Potentiometric Flow Injection [6], HPLC-ICP-MS [7], HPLC [8], Thin Layer Chromatography (TLC) [9], Spectrophotometric Quantitative [10], and UV-Vis Spectrophotometer [11][12] [13]. The dispersive liquid liquid microextraction (DLLME) and cloud point extraction have many advantages in the determination of pharmaceutical preparation like rapid, safety and low cost [14].In this work, the proposed technique is based ion-pair reaction of bromohexine HCl with alizarin yellow reagent in the acidic medium, then evaluation and pre-concentration…”

Spectrophotometric Quantitative Determination of Bromhexine Hydrochloride in Bulk and Pharmaceutical Dosage Form using PDEAB Reagent

“…Because of its physiological importance, the drug has been quantified by exploiting its chemical 5,6 and physical properties [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] . The different analytical methods used to quantify the drug as a single active pharmaceutical ingredient include flow injection analysis with ion RESEARCH ARTICLE selective electrodes 7 , inductively coupled plasma mass spectrometry 8 , electrokinetic chromatography 9 , electrochemical oxidation at the glassy carbon electrode 10 , liquidchromatography 11 , liquid gas chromatography 12 , GC with mass detection 13 and voltammetry 14 .…”