New microextraction methods for the evaluation of bromhexine HCl in pure and pharmacological formulations.

Abstract

In this study, ion-pair reactions were used to investigate bromohexine HCl. The development of simple, accurate, sensitive, low-cost, and efficient extraction methods for bromohexine HCl separation, such as the DLLME and cloud point extraction techniques, are described as bromohexine HCl estimation methodologies. These methods employed the interaction of bromohexine HCl with alizarin yellow reagent to produce a yellow complex in an acidic medium (pH = 5). The complex's maximum absorbance intensity was 480 nm, and the stoichiometry for both continuous variation and molar ratio methods was determined to be 1:1. The dispersive liquid liquid microextraction (DLLME) method's concentration range (1-23µg.mL -1 ), the Beers law was obeyed with correlation coefficient (R 2 =0.998), limit of detection as (0.055µg.mL -1 ), limit of quantification as (0.183µg.mL -1 ) and molar absorptivity as (23930.2L.mol -1 .cm -1 ).In the second technique, the cloud pointextraction method, The linearity of calibration curve above was the range between (1-40 µg.mL -1 ), the correlation coefficient (R 2 =0.998) and molar absorptivity was (13202.88L.mol -1 .cm -1 ), (LOD) and (LOQ) were (0.141µg.mL -1 ) and (1.4641µg.mL -1 ), respectively. The proposed techniques can be used for the determination of bromohexine HCl in both pure and pharmaceutical formulations with very good success.

Determination of Cefixime inclusion complex with 2-hydroxypropyl-β-cyclodextrin and extraction using DLLME and SIHLLME

“…*Corresponding author at: Department of Chemistry, College of Science, Tikrit University, Sallah-Aldin, Iraq ORCID:https://orcid.org/0000-0000-00000-;Tel:+9647816689990 E-mail address: Araf.I.Jabbar.chem869@st.tu.edu.iq liquid chromatography-mass spectrometry (LC-MS) [14,15], and fluorescence spectrophotometry [16][17][18], were available for the analysis of CFX. Dispersive Liquid-Liquid Micro-Extraction (DLLME) and Salt-Induced Liquid-Liquid Micro-Extraction (SIHLLME) have many advantages such as speed, low cost and safety [19][20][21][22][23]. The aim of the study was the simultaneous determination of CFX using inclusion complex with 2-hydroxypropyl-β-cyclodextrin as a reagent in combination with the DLLME and SIHLLME as extraction methods.…”

Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLME

“…Various analytical methods were utilized to determine the TMP containing spectral techniques [11][12][13][14][15], liquid chromatography [16], HPLC [17], and the electrical method [18,19]. The dispersive liquid-liquid microextraction (DLLME) has many advantages like rapid, low cost, and safety [20,21]. The aim of this work was for the simultaneous spectrophotometric determination of TMP by ion-pair complex with alizarin yellow as a reagent combine with LLE and DLLME methods.…”