Potentiation effect on accelerating diabetic wound healing using 2-N,6-O-sulfated chitosan-doped PLGA scaffold

Abstract

This study provides an effective strategy by activation with growth factor and modulating the redox microenvironment of the diabetic wound to enhanced re-epithelialization.

Efficacy of alginate‐and chitosan‐based scaffolds on the healing of diabetic skin wounds in animal experimental models and cell studies: A systematic review

“…The articles were excluded because of study design, study topic (not diabetic wound), human studies, or studies not report wound healing as outcome measurements. Finally, 29 21,24‐51 studies that evaluated the effect of chitosan or alginate on diabetic wound healing were included. Figure 1 illustrated the trial selection process.…”

“…Table 1 presented the descriptive characteristics of the included articles. Overall, there were 23 trials 21,24‐30,32‐46 on chitosan, three trials on alginate, 31,47,48 and three trials on the combination of alginate and chitosan 49‐51 . The animal studies were conducted from 2002 and 2019.…”

“…Only one study provided detailed information about how randomization was carried out in the experiment group and control group and adequately reported on the assignment of samples 21 . Twenty‐three studies had insufficient information about how randomization was carried out in the experiment group and control group or provided inadequate report on the assignment of samples 21,24‐26,28‐37,42,44‐48,50,51 . Five studies did not give information about the randomization 27,38‐41 .…”

“…Of included studies, eight studies reported the effect of chitosan‐based scaffolds on wound healing in cell studies 21,24,25,27‐31 . Escherichia coli , Pseudomonas aeruginosa , Bacillus subtilis , and Staphylococcus aureus 24,28 were used in the in vitro studies to examine the antibacterial activities of chitosan.…”

“…Escherichia coli , Pseudomonas aeruginosa , Bacillus subtilis , and Staphylococcus aureus 24,28 were used in the in vitro studies to examine the antibacterial activities of chitosan. Human fibroblasts, aneuploid immortal keratinocytes, 21,25 mouse leukemic monocytes/macrophages, 26 HaCaT cells, HUVE cells, NIH/3T3 cells, 27 human keratinocyte cell lines, 26,29 and diabetic human primary keratinocyte cell lines 30 were used in vitro to examine wound healing effects. Two studies 24,28 tested the effect of chitosan‐based scaffolds on antimicrobial activity in cell studies.…”