Potentials for health and therapeutic benefits of garlic essential oils: Recent findings and future prospects

Ezeorba, Timothy Prince Chidike; Chukwudozie, Kingsley Ikechukwu; Ezema, Chuka; Anaduaka, Emeka Godwin; Nweze, Ekene John; Okeke, Emmanuel Sunday

doi:10.1016/j.prmcm.2022.100075

Cited by 37 publications

(11 citation statements)

References 147 publications

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“…Despite the many advantages of modern extraction methods, the optimization of time, temperature, and solvent parameters in the adaptation to the plant type is important for each method and contributes to quality and efficiency [ 42 ]. Recent technological advances and the development of devices ensure greater extraction efficiency [ 43 ]. UAE, MAE, PLE, and SFE can change the content of bioactive compounds, including AC [ 44 ].…”

Section: Methods Of Isolation Of Active Compoundsmentioning

confidence: 99%

“…The most commonly used methods for extracting garlic oil are steam hydrodistillation and hot solvent extraction. Water temperature, distillation time, and particle size are factors that influence the efficiency of hydrodistillation extraction [ 43 ]. The temperature, the analytical degree of the solvents, the maceration time, and the drying method are important factors in the extraction of garlic oils with organic solvents [ 43 ].…”

Section: Methods Of Isolation Of Active Compoundsmentioning

confidence: 99%

“…Water temperature, distillation time, and particle size are factors that influence the efficiency of hydrodistillation extraction [ 43 ]. The temperature, the analytical degree of the solvents, the maceration time, and the drying method are important factors in the extraction of garlic oils with organic solvents [ 43 ]. According to the results obtained by Chen et al [ 46 ], parameters ensuring the best quality of garlic oil extraction with the use of solvents are as follows: temperature 45 °C, time 42 min, solvent to raw material ratio 4:1, number of extractions 4 [ 46 ].…”

Section: Methods Of Isolation Of Active Compoundsmentioning

confidence: 99%

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Methods of Isolation of Active Substances from Garlic (Allium sativum L.) and Its Impact on the Composition and Biological Properties of Garlic Extracts

2022

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Garlic (Allium sativum L.) is widely used in the human diet and in scientific research due to its biological properties. Various factors, e.g., temperature, pressure, extraction method, type of solvent, size, and territorial origin of garlic, affect the amount and type of bioactive compounds obtained from garlic extracts. In turn, the content of bioactive compounds correlates with the biological activity of the extracts. Therefore, the aim of this review was to summarize the current state of knowledge of the methods and effectiveness of isolation of active substances from garlic and their impact on the garlic extract composition and, consequently, biological properties. According to the literature, extracts obtained using water as a solvent are mainly responsible for antimicrobial properties, which is related to, inter alia, the high content of allicin. The use of alcohols, such as methanol or ethanol, is associated with the outstanding antioxidant power of extracts resulting from the presence of phenolic compounds. In turn, due to the presence of diallyl disulfide and disulfide trisulfide, garlic oil has anticancer potential. Acetone is the most effective organic solvent; however, it is not suitable for immediate consumption.

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Section: Methods Of Isolation Of Active Compoundsmentioning

confidence: 99%

Section: Methods Of Isolation Of Active Compoundsmentioning

confidence: 99%

Section: Methods Of Isolation Of Active Compoundsmentioning

confidence: 99%

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Methods of Isolation of Active Substances from Garlic (Allium sativum L.) and Its Impact on the Composition and Biological Properties of Garlic Extracts

2022

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“…Plants are endowed with phytochemicals such as alkaloids, flavonoids, steroids, saponins, and tannins that play a vital role in preventing and managing hyperglycemia. 2 , 13 , 16 , 17 , 38 Alkaloids, aromatic heterocyclic compounds containing nitrogen as a hetero atom, are employed as pharmaceutical agents to treat neurological disorders, cancer, and DM. 27 The anti-DM activities of alkaloids vary from the inhibition of carbohydrate digestive enzymes, improvement of insulin sensitivity and secretion, glucose uptake, and regulation of gene expression.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Characterization, Functional Nutrition, and Anti-Diabetic Potentials of Leptadenia hastata (pers) Decne Leaves: In Silico and In Vitro Studies

Chukwuma

Nworah

Apeh³

et al. 2022

Bioinform Biol Insights

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The geometrical increase in diabetes mellitus (DM) and the undesirable side effects of synthetic drugs have intensified efforts to search for an effective and safe anti-diabetic therapy. This study aimed to identify the antioxidant and anti-diabetic agents in the ethanol extract of Leptadenia hastata (EELH). The phytochemicals, antioxidant vitamins, and minerals present in EELH were determined using standard procedures to achieve this aim. Gas chromatography coupled with mass spectroscopy and flame ionization detector (GC-MS/GC-FID) was employed to identify bioactive compounds. An e-pharmacophore model was generated from the extra precision, and energy-minimized docked position of standard inhibitor, acarbose onto human pancreatic amylase (HPA, PDB-6OCN). It was used to screen the GC-MS/GC-FID library of compounds. The top-scoring compounds were subjected to glide XP-docking and prime MM-GBSA calculation with the Schrodinger suite-v12.4. The Adsorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) prediction of the best-fit compounds was made using SwissADME and PROTOX-II webservers. Further validation of the docking results was performed with the in vitro analysis of the α-amylase and α-glucosidase inhibitory activities. EELH contains appreciable amounts of antioxidant and anti-diabetic phytoconstituents. The top-4 scoring compounds (rutin, epicatechin, kaempferol, and naringenin) from the EELH phytochemical library interacted with amino acid residues within and around the HPA active site. The ADMET prediction shows that epicatechin, kaempferol, and naringenin had favorable drug-likeness, pharmacokinetic properties, and a good safety profile. EELH demonstrated good inhibitory actions against α-amylase and α-glucosidase with 1C50 values of 14.14 and 4.22 µg/mL, respectively. Thus, L hastata phytoconstituents are promising novel candidates for developing an anti-diabetic drug.

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“…Therefore, the rest of the annual garlic production that does not meet the size requirements is a residue that can be processed to obtain a wide variety of products with culinary and pharmacological applications [11]. Garlic oil is produced commercially by steam distillation and is widely used in alimentary and pharmaceutical industries [12] and has a wide range of biological effects as an antioxidant [13], antibacterial [13], acaricide [14,15] and insecticide [16,17]. Specifically, nematicidal activity of this oil has been described against the pine wood nematode, Bursaphelenchus xylophilus [18] and the root-knot nematode M. incognita on cucumber [19] and tomato plants [20,21].…”

Section: Introductionmentioning

confidence: 99%

Valorization of the Hydrolate Byproduct from the Industrial Extraction of Purple Alium sativum Essential Oil as a Source of Nematicidal Products

Pretel

González-Coloma⊥

Castillo³

et al. 2022

Life

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The hydrolate byproduct resulting from the industrial essential oil extraction of Spanish purple garlic has been studied against the root-knot nematode Meloidogyne javanica by in vitro and in vivo bioassays. The essential oil, the hydrolate and its organic fraction caused high mortality of juveniles, suppressed egg hatch, and reduced nematode infection and reproduction on tomato plants. The nematicidal compounds of garlic oil, diallyl disulfide and diallyl trisulfide, were the major components of the hydrolate organic fraction. These findings have important implications for the development of new nematode control products based on garlic hydrolate compounds and highlight the recovery of waste from essential oils extraction, promoting a circular economy.

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Potentials for health and therapeutic benefits of garlic essential oils: Recent findings and future prospects

Cited by 37 publications

References 147 publications

Methods of Isolation of Active Substances from Garlic (Allium sativum L.) and Its Impact on the Composition and Biological Properties of Garlic Extracts

Methods of Isolation of Active Substances from Garlic (Allium sativum L.) and Its Impact on the Composition and Biological Properties of Garlic Extracts

Phytochemical Characterization, Functional Nutrition, and Anti-Diabetic Potentials of Leptadenia hastata (pers) Decne Leaves: In Silico and In Vitro Studies

Valorization of the Hydrolate Byproduct from the Industrial Extraction of Purple Alium sativum Essential Oil as a Source of Nematicidal Products

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