Potentialities and prospects for the clinical application of low-rate membrane oxygenators with heat exchangers

Stimulating effect of low-flow membrane oxygenation on peripheral blood immunocompetent cells

“…The mechanisms underlying this activity remain obscure. Electron microscopy studies showed that platelets adsorb onto the target cells, after which ultrastructural changes typical of periodical secretion (hypertrophy of the Golgi apparatus, enlargement of secretory granules, and their orientation towards the contact zone) occur [5]. These changes are similar to those observed in T lymphocytes contacting with tumor cells [6].…”

“…This markedly enhances platelet cytotoxicity [5]. Similarly to T cells and monocytes, platelets exhibit killer activity towards malignant cells.…”

“…The ACL strain proved to be the most sensitive target. Incubation of platelets from both healthy donors and oncological patients with PAF (10 pM-100 nM) markedly increases killer activity of platelets [5]. Platelet cytotoxic activity is influenced by various proteases [12].…”

“…Blood oxygenation during perfusion with small volumes finds new clinical applications [5]. Investigation and clinical use of oxygenation, including the low-flow membrane oxygenation (LFMO), became more available after serial production of low flow rate oxygenators with true membranes (MOST-1903, nominal blood flow rate 500 ml/min according to the American standard, and MOST-1801, 150 ml/min) had been started by Kvant company (Moscow).…”