The process by which biological fluids are crystallized makes it possible to identify rhythmic undulatory oscillations occurring in the liquid phase of the medium. Pathological changes in the body impair physiological rhythms at different levels, these impairments being reflected in the biocrystalline structure of a biological fluid during its self-organization. Targeted modifications of the rhythm characteristic of a biofluid may help to evaluate the resistance of the organism to environmental factors. Key Words: biological fluids; biorhythm; crystallization; structuralization; spatio-temporal organizationThe theoretical basis of chronobiology is the axiom that there exist spatio-temporal forms of organization of the living matter [2,4,6,7].Under physiological, highly stressful, or pathological conditions, molecular composition of tissue and chemical interactions between its components responsible for the oscillatory behavior change continuously. Any wave is a signal, and the concentration wave in a chemical medium is not an exception. Activation and inhibition of chemical reactions in a feedback manner provide the basis for rhythmic oscillatory processes in biological systems. These processes, which are best reflected in the structural crystalline organization of biological fluids, determine the functioning of individual elements, systems, and the whole organism.In terms of synergism, the complex and well coordinated processes occurring in biological fluids can be regarded as self-organizing [5,[10][11][12]. Socalled nonequilibrium phase transitions (crystallization of a liquid during freezing or drying) exemplify Russian Institute of Clinical and Experimental Immunology, Ministry of Health of the Russian Federation, Moscow; Moscow Region Institute of Clinical Research a self-organization process. This is not a transformation of chaos into order, but rather a phase-transition process from one order of particular quality to another.We have examined physical parameters of threedimensional structures arising upon phase transition of various biofluids to solid state during self-organization. Transition of a biological fluid to the solid state is a process whereby a structural order of higher level is achieved.It is known from general crystallography [8] that crystallization of melted ptutonic rocks following volcanic eruptions proceeds in three consecutive stages each of which is characterized by formation of a distinct structural zone: zone of idiomorphic crystals, zone of mixed structures, and amorphous zone. We have observed similar processes in biofluids upon drying. MATERIALS AND METHODSBiological fluids (blood serum or urine) were applied as a drop (0.02 ml) onto a slide, allowed to dry at room temperature (18-25~ and viewed under a microscope in transmitted light at different magnifications.Urine and serum samples in optical cells were studied under an MBI-15 microscope and a Polivar
Reversible cerebral ischemia of medium severity was reproduced in male Wistar rats by bilateral occlusion of the common carotid arteries. Solid-phase structures (anisomorphons) were obtained by marginal dehydration of the serum. Small focal isotropic defects in the serum anisomorphon texture were found in 100% cases during occlusion of the carotid arteries. Similar signs were detected in all patients with chronic cerebral ischemia, which proved specificity of this morphological marker of the disease.
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