Potential thiamine deficiency in elderly patients with gastrointestinal cancer undergoing chemotherapy

Yasu, Takeo; Iimura, Yohei; Momo, Kenji; Kuroda, Seiichiro

doi:10.5414/cp203595

Cited by 2 publications

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“…Previous studies have shown that mild deficiency in thiamine serum levels was associated with neurological symptoms (cognitive impairment, attention decline, and mood disorder) in patients with gastrointestinal cancer. 17 18 19 However, similar studies with patients with hematological cancer are required.…”

Section: Discussionmentioning

confidence: 99%

“… 1 3 Although the number of patients was small, previous studies have shown that even mild deficiency in thiamine serum levels was associated with neurological symptoms (cognitive impairment, attention decline, and mood disorder) in patients with gastrointestinal cancer. 17 18 19 However, there have been no reports on this in patients with hematological cancer. The relationship between mild-to-severe thiamine deficiency and neurological symptoms, including mild or nonspecific symptoms in patients with hematological cancer receiving chemotherapy, should be evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Thiamine Deficiency and Neurological Symptoms in Patients with Hematological Cancer Receiving Chemotherapy: A Retrospective Analysis

Iimura

Andoh

Kawamata

et al. 2021

JNRP

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Objectives Patients with hematological cancer receiving chemotherapy have a high risk of thiamine deficiency due to accelerated thiamine usage by tumor cells. Mild or severe thiamine deficiency can lead to varying degrees of neurological symptoms. We evaluated the relationship between thiamine deficiency and neurological symptoms, including mild or nonspecific symptoms, and the influence of chemotherapy on thiamine serum levels in patients with hematological cancer receiving chemotherapy. Materials and Methods We retrospectively identified 42 patients diagnosed with hematological cancer at our hospital, using electronic medical records collected from March 2019 to March 2020. We evaluated the risk factors associated with neurological symptoms (mild-to-severe cognitive impairment, attention impairment, and mood or emotional disorder), the relationship between the presence of neurological symptoms and thiamine serum levels, and changes in thiamine serum levels after chemotherapy. Results Thiamine deficiency was significantly associated with neurological symptoms. The thiamine serum levels in the group with neurological symptoms were significantly lower than those in the group without neurological symptoms. The Wilcoxon rank-sum test showed that thiamine serum levels after chemotherapy were significantly lower than those before administration of chemotherapy. Conclusion Thiamine serum levels in patients with hematological cancer may be used as a reference to maintain neurological status during chemotherapy.

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Section: Discussionmentioning

confidence: 99%