Association between thiamine decrease and neuropsychiatric symptoms in gastrointestinal and hematological cancer patients receiving chemotherapy

Iimura, Yohei; Kurokawa, Tomohiro; Andoh, Shohei; Kanemoto, Yoshitsugu; Kawamata, Toyotaka; Yazawa, Kentaro; Sato, Aki; Yokoyama, Kazuaki; Imai, Yumiko; Tsurita, Giichiro; Ahiko, Yuka; Aikou, Susumu; Shida, Dai; Nojima, Masanori; Tojo, Arinobu; Sugiura, Masaki; Kuroda, Seiichiro

doi:10.1016/j.biopha.2021.111929

Cited by 5 publications

(1 citation statement)

References 42 publications

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“…The average thiamine storage capacity is approximately 18 days, and its deficiency can occur in any condition of malnutrition [14]. It has been postulated that the thiamine deficiency observed in abdominal cancer patients may be caused by nutrient malabsorption because of the impact on digestive enzyme production and/or lack of appetite, also caused by chemotherapy [15,16]. A case study of a woman with PaC treated with paclitaxel and gemcitabine-based chemotherapy for 6 months showed that the In PaC patients, the highest risk of water-soluble vitamin deficiency involves thiamine (vitamin B1), niacin (vitamin B3), and pyridoxine (vitamin B6).…”

Section: Vitamin B1mentioning

confidence: 99%

Vitamin Nutritional Status in Patients with Pancreatic Cancer: A Narrative Review

Azzini,

Furini,

Polito

et al. 2024

IJMS

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Due to the high mortality rate in Western countries, pancreatic cancer is considered one of the big killers, leaving patients and their families with little hope upon diagnosis. Although surgical and drug therapies are critical for cancer patients to improve life expectancy and alleviation of suffering, nutrition plays a key role in improving cancer treatment outcomes. This narrative review, conducted as part of the activities of the Italian Society of Human Nutrition (SINU) working group in oncology, focuses on the prevalence of vitamin malnutrition among pancreatic cancer patients. The results of the literature search show that pancreatic cancer patients are at a heightened risk of water-soluble vitamin deficiencies, particularly of vitamins B1, B3, and B6. Additionally, they also face an increased risk of deficiency of fat-soluble vitamins. Among these vitamins, the potential role of vitamin D in pancreatic cancer has garnered the most attention, with its plasma levels being identified as a significant factor in patient survival. Investigating vitamin nutritional status could provide valuable insights for incorporating nutritional approaches into the prevention and treatment of pancreatic cancer, thereby reducing the exacerbation of symptoms associated with the diagnosis.

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Section: Vitamin B1mentioning

confidence: 99%

Vitamin Nutritional Status in Patients with Pancreatic Cancer: A Narrative Review

Azzini,

Furini,

Polito

et al. 2024

IJMS

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Race explains substantial variance in whole blood thiamine diphosphate concentrations

Zahr

2024

Nutrition Research

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What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder

Ishida¹,

Sato²,

Sato³

et al. 2023

Pall Supp Care

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Objectives Thiamine deficiency (TD) presents with various physical and psychiatric symptoms, but no cases with depression-like symptoms have been reported. Methods We report a patient with cancer who appeared to attempt suicide as a consequence of depressive mood likely related to TD. Results The patient was a 58-year-old woman diagnosed with recurrent endometrial cancer, with lung metastasis and pelvic dissemination. The patient apparently attempted suicide was referred to the psycho-oncology department. At the time of the examination, major depressive disorder was suspected based on her mental symptoms, but when thiamine was administered intravenously in response to her poor dietary intake, her palpitations, dyspnea, anorexia, and insomnia improved, and her suicidal ideation disappeared at her reexamination 1 hour later after thiamine administration. Significance of results It is likely that the observed palpitations, dyspnea, anorexia, and insomnia, as well as the severe depression and the attempted suicide, which were thought to be physical symptoms associated with depression, were actually related to TD. Suicidal ideation and attempted suicide are conspicuous as psychiatric symptoms. However, in such cases, rather than simply starting treatment for depression, it is necessary to consider reversible TD as a cause of these symptoms and perform differential diagnosis to confirm the physical illness.

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Association between thiamine decrease and neuropsychiatric symptoms in gastrointestinal and hematological cancer patients receiving chemotherapy

Cited by 5 publications

References 42 publications

Vitamin Nutritional Status in Patients with Pancreatic Cancer: A Narrative Review

Vitamin Nutritional Status in Patients with Pancreatic Cancer: A Narrative Review

Race explains substantial variance in whole blood thiamine diphosphate concentrations

What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder

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