Potential therapies for peanut allergy

Peanut T-cell epitope discovery: Ara h 1

“…7 These are associated with high rates of adverse reactions or low efficacy. 8 Compared with crude peanut extract (CPE), 9 peptide-based immunotherapy using T cell epitope-containing peptides (too short to effectively cross-link allergen-specific IgE on mast cells and basophils) might provide efficacious desensitization without significant reactions. This has been achieved in allergic subjects with Fel d 1 for cat allergy, 10 phospholipase A 2 for vespid allergy 11 and with ovalbumin (egg) 12 and Ara h 1 in mice with egg and peanut allergy.…”