Potency of T-Cell Epitope-Based Peptide Vaccines in Food Allergy Treatment

Pelgrim, Iris; Savelkoul, H.F.J.

doi:10.1007/978-3-030-16073-9_17

Cited by 1 publication

(2 citation statements)

References 148 publications

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“…In the PITA study, Fauquert et al 146 used sealed capsules containing peanut flour instead of vehicle foods, to bypass the oral cavity and upper digestive tract, to limit adverse side effects involving the mouth and oesophagus. Besides encapsulation, other novel (experimental) AIT approaches aimed at increasing clinical efficacy and reducing adverse side effects are worth considering 145,155,156 , most of which require knowledge of the immunodominant B-and T-cell epitopes of the major cashew allergens ( Figure 5B). For example, peptides or food allergens can be engineered or chemically modified to lose their IgE cross-linking effectiveness, whilst retaining their ability to modulate allergen-specific T cells 145,156 , as evident from peanut AIT studies 15,154 .…”

Section: Treatment Strategiesmentioning

confidence: 99%

“…Cashew nutspecific T cell responses directed towards Ana o 1 and Ana o 2 were studied by Archila et al 159 . They identified multiple cashew nut unique peptides and suggested that Ana o 1 and Ana o 2 share cross-reactive T cell epitopes with hazelnut and pistachio, but their clinical relevance in cashew peptide immunotherapy still needs to be determined 155 .…”

Section: Treatment Strategiesmentioning

confidence: 99%

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Cracking the cashew nut : Strategies to identify novel allergens

Bastiaan‐Net¹

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Significant efforts are necessary to introduce new dietary protein sources to feed a growing world population while maintaining food supply chain sustainability. Such a sustainable protein transition includes the use of highly modified proteins from side streams or the introduction of new protein sources that may lead to increased clinically relevant allergic sensitization. With food allergy being a major health problem of increasing concern, understanding the potential allergenicity of new or modified proteins is crucial to ensure public health protection. The best predictive risk assessment methods currently relied on are in vivo models, making the choice of endpoint parameters a key element in evaluating the sensitizing capacity of novel proteins. Here, we provide a comprehensive overview of the most frequently used in vivo and ex vivo endpoints in murine food allergy models, addressing their strengths and limitations for assessing sensitization risks. For optimal lab-to-lab reproducibility and reliable use of predictive tests for protein risk assessment, it is important that researchers maintain and apply the same relevant parameters and procedures. Thus, there is an urgent need for a consensus on key food allergy parameters to be applied in future food allergy research in synergy between both knowledge institutes and clinicians.

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Section: Treatment Strategiesmentioning

confidence: 99%

Section: Treatment Strategiesmentioning

confidence: 99%

Cracking the cashew nut : Strategies to identify novel allergens

Bastiaan‐Net¹

View full text Add to dashboard Cite

show abstract

Potency of T-Cell Epitope-Based Peptide Vaccines in Food Allergy Treatment

Cited by 1 publication

References 148 publications

Cracking the cashew nut : Strategies to identify novel allergens

Cracking the cashew nut : Strategies to identify novel allergens

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