Potential targets by pentacyclic triterpenoids from Callicarpa farinosa against methicillin-resistant and sensitive Staphylococcus aureus

Chung, Pooi Yin; Chung, Lip Yong; Parasakthi, N

doi:10.1016/j.fitote.2014.01.026

Cited by 47 publications

(27 citation statements)

References 47 publications

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“…These were active against the bacterial strains that showed a profile of multi-resistance to several classes of antibiotics, indicating that the mechanisms of action of antibacterial substance are able to overcome (Scalbert, 1991). Triterpenoids from Callicarpa farinosa showed antimicrobial activities against different strains of S. aureus, with MIC ranging from 2 to 512 µg/ml (Chung et al, 2014). Flavonoids have been reported to possess antimicrobial activity against a wide range of pathogens as flavonoids from Dorstenia species that showed activity against methicillin-resistant S. aureus (MRSA) strains with MICs values ranged between 0.5 to 128 μg/ml (Dzoyem et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Synergistic activity from Hymenaea courbaril L. and Stryphnodendron adstringens (Mart.) Coville against multidrug-resistant bacteria strains

Camargos¹,

Herrera²,

Santos³

et al. 2015

J. Med. Plants Res.

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Infections caused by multidrug-resistant bacteria are a problem of public health, turning the search for natural products an alternative to antibiotics of great importance. The aim of this study was to investigate the in vitro antimicrobial activities of Hymenaea courbaril and Stryphnodendron adstringens against bacterial clinical isolates. The crude extracts of both vegetal species in study showed bacteriostatic activity against almost all bacteria evaluated, with minimum inhibitory concentration (MIC) ranging from 125 to 1250 µg/ml. The bacteriostatic activity was observed in all the fractions of H. courbaril and S. adstringens against at least one bacterial strain, except in the fraction dichloromethane of S. adstringens. In regard to bactericidal activity, H. courbaril was active only against E. faecalis, and S. adstringens showed activity against all bacterial strains, except to Enterococcus faecalis. The combination of extracts showed potent synergistic antimicrobial activity, with MIC values of 31.25 µg/ml against Acinetobacter baumannii, Escherichia coli and Staphylococcus aureus. S. adstringens were considered less cytotoxic compared to H. courbaril and the half-maximum cytotoxic concentration (CC 50) resulting from the combination of the two plants was 0.0082 ± 3.19 mg/ml. The results showed for the first time the synergic antibacterial activities of H. courbaril and S. adstringens against resistant bacteria, suggesting their potential use to development of new drugs.

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Section: Discussionmentioning

confidence: 99%

Synergistic activity from Hymenaea courbaril L. and Stryphnodendron adstringens (Mart.) Coville against multidrug-resistant bacteria strains

Camargos¹,

Herrera²,

Santos³

et al. 2015

J. Med. Plants Res.

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“…The compound α-amyrin has been reported to exhibit antimicrobial activities against S. aureus. The compound α-amyrin regulates multiple desirable targets in cell division, the two-component system, ABC transporters, fatty acid biosynthesis, peptidoglycan biosynthesis, aminoacyl-tRNA synthetase, and ribosome and b-lactam resistance pathways [45], resulting in the destabilization of the bacterial cell membrane, a halt in protein synthesis, and inhibition of cell growth that eventually lead to cell death [46]. Furthermore, it causes disorganizing effects on cardiolipin-rich domains present in the membrane of E. coli [47].…”

Section: Gas Chromatography Mass Spectrometry (Gc/ms) Analysismentioning

confidence: 99%

Cornus macrophylla, the Antibacterial Activity of Organic Leaf Extracts and the Characterization of the More Lipophilic Components by GC/MS

et al. 2020

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In the present study, the antibacterial activity of Cornus macrophylla was examined. Organic solvent extracts of leaves were prepared using methanol, n-hexane, chloroform, and ethyl acetate. Antibacterial activity was examined by using a 100 mg/mL extract concentration. Penicillin was kept as a positive control while dimethyl sulfoxide was taken as a negative control. Methanolic extract exhibited a 21.5, 36.3, 25.3, and 23.7 mm inhibition zone diameter (IZD); n-hexane showed a 33, 40, 32.8, and 28.7 mm IZD; chloroform showed a 18.8, 29, 22.3, and 21.6 mm IZD; and ethyl acetate showed a 23.5, 30.2, 30, and 22.3 mm IZD against Erwinia carotovora, Pseudomonas syringae, Ralstonia solanacearum, and Xanthomonas axonopodis, respectively. The n-hexane extract revealed high antibacterial activity against all bacterial species as compared with methanolic, chloroform, and ethyl acetate extract. Gas Chromatography Mass Spectrometry (GC/MS) analysis of n-hexane extract depicted the presence of 55 compounds. Out of these compounds, one compound, identified as α-amyrin (Mol. wt = 426), exhibited the maximum peak area (32.64%), followed by A’-Neogammacer-22(29)-en-3-ol, acetate, (3.beta.,21.beta.)- (Mol. wt = 468) and β-amyrin (Mol. wt = 426) having peak areas of 25.97 and 6.77%, respectively. It was concluded that the antibacterial activity observed during the present investigation may be due to these compounds.

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“…The genes affected by treatment with subinhibitory doses of betulinic acid were components of ABC transporters (two), ribosomal assembly (one), and a two-component regulatory system (two). This last type is associated with both the virulence and antibiotic response of the bacterial cell [78].…”

Section: Parasiticidal and Anti-infectious Activitymentioning

confidence: 99%

New Pharmacological Opportunities for Betulinic Acid

2017

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Betulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated from birch trees, but present in many other botanical sources. It is found in different plant organs, both as a free aglycon and as glycosyl derivatives. A wide range of pharmacological activities has been described for this triterpenoid, including antiviral and antitumor effects. In addition, several other interesting properties have been identified in the fields of immunity and metabolism, namely antidiabetic, antihyperlipidemic, and anti-inflammatory activities. Taken together, these latter three properties make betulinic acid a highly interesting prospect for treating metabolic syndrome. The present review focuses on the therapeutic potential of this agent, along with several of its semisynthetic derivatives, which could open new frontiers in the use of natural product-based medicines.

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Potential targets by pentacyclic triterpenoids from Callicarpa farinosa against methicillin-resistant and sensitive Staphylococcus aureus

Cited by 47 publications

References 47 publications

Synergistic activity from Hymenaea courbaril L. and Stryphnodendron adstringens (Mart.) Coville against multidrug-resistant bacteria strains

Synergistic activity from Hymenaea courbaril L. and Stryphnodendron adstringens (Mart.) Coville against multidrug-resistant bacteria strains

Cornus macrophylla, the Antibacterial Activity of Organic Leaf Extracts and the Characterization of the More Lipophilic Components by GC/MS

New Pharmacological Opportunities for Betulinic Acid

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