Potential Role of Serum Magnesium Measurement as a Biomarker of Acute Falciparum Malaria Infection in Adult Patients

Garba, I.; Ubom, Gregory A.

doi:10.1385/bter:114:1:115

Cited by 9 publications

(10 citation statements)

References 19 publications

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“…The present study revealed a significant (p<0.01) decrease in the magnesium level of the P. falciparum infected blood samples as compared to the P. falciparum free sample. This is however contrary to the result obtained in a study by Garba who observed an increase in the plasma magnesium level of malaria patients suffering from P. falciparum parasite [34]. This disparity might be due to the different parasite counts and stages presented by the patients used for the study.…”

Section: Levels Of Electrolytes (Ca Mg K Na) In P Falciparum Infecontrasting

confidence: 99%

Assessment of the Antioxidant Status and Selected Electrolytes Level in Some Nigerian Malarial Patients: A Mini Comparative Study

Abiola¹,

Oa²,

Va³

2018

Biochem Pharmacol

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Malaria remains an endemic infection which results in nutritional deficiencies. This study was set up to assess the antioxidant capacity and the levels of some selected minerals in the plasma samples of malaria infected individuals. Blood specimens were obtained from ten P. falciparum infected patients and ten healthy individuals using standard clinical procedures. Plasma levels of superoxide dismutase, catalase and glutathione were determined using standard spectrophotometry methods. Plasma levels of the following electrolytes; calcium, sodium, magnesium and potassium were determined using standard atomic absorption spectrometry methods: Results show that there was a significant (p<0.01) decrease in the plasma levels of SOD, CAT and GSH, calcium, magnesium and sodium of P. falciparum infected individuals as compared to P. falciparum free individuals with no significant (p> 0.01) difference in the serum levels of potassium for both. The presence of malaria parasites (P. falciparum) in blood affects the activities of antioxidant enzymes and micro nutrients in patients.

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Section: Levels Of Electrolytes (Ca Mg K Na) In P Falciparum Infecontrasting

confidence: 99%

Assessment of the Antioxidant Status and Selected Electrolytes Level in Some Nigerian Malarial Patients: A Mini Comparative Study

Abiola¹,

Oa²,

Va³

2018

Biochem Pharmacol

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“…In another similar study, it was observed that the serum magnesium level in malaria patients increased about threefold compared to controls. In this study, they also mentioned that the increase in magnesium levels may be due to hemolysis since red blood cells contain high amounts of magnesium [31]. In another study, a relationship was found between magnesium levels on admission and 30-day mortality in pneumonia patients.…”

Section: Is the Increase In Magnesium Levels Cause Or Consequence?mentioning

confidence: 73%

The Relation Between Trace Element Status (Zinc, Copper, Magnesium) and Clinical Outcomes in COVID-19 Infection During Pregnancy

Anuk

Polat

Akdas

et al. 2020

Biol Trace Elem Res

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SARS CoV-2 is a novel coronavirus which has caused many deaths in the recent pandemic. This study aimed to determine zinc, copper and magnesium status on pregnant women with COVID-19. 100 healthy (33/32/35) and 100 SARS-CoV-2 positive (34/33/33) pregnant women were included in the study according to their trimesters. Blood samples were obtained from the patients along with the initial laboratory tests for clinical outcomes upon their first admission to hospital. In the first and third trimesters serum zinc level was lower (p:0,004 and p:0,02), serum copper level was higher (p:0,006 and p:0,008), the Zn / Cu ratio decreased(p < 0.0001 and p < 0.0001) and the serum magnesium level was higher(p < 0.0001 and p < 0.0001) in the COVID-19 group.In the second trimester COVID-19 patients had lower serum zinc (p:0,05) and copper levels (p:0,0003) compared to controls. Disease severity correlated with zinc/copper ratio in COVID19 patients (p:0.018, r:-0.243). Serum zinc and Zn/Cu ratio levels had a negative relationship with acute phase markers such as IL-6, Erythrocyte Sedimentation Rate, procalcitonin and Creactive Protein. Also, increased serum magnesium level may play a role in decreased white blood cell, neutrophil, lymphocyte cell count and increased CRP levels in the third trimester. This study indicated that trace element status changed in pregnant women with COVID-19. The effect of trace elements on pregnant women diagnosed with COVID-19 infection was investigated in comparison with healthy pregnant women for the first time. This effect will be revealed better in more comprehensive studies to be planned in the future.

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“…Another similar result was observed in malaria patients that serum magnesium level was increased nearly 3 fold than controls. They mentioned increase of magnesium levels might be depended on hemolysis because red blood cells contain high amounts of magnesium [27]. In another study the association was found with magnesium levels on admission and 30-day mortality in patients with pneumonia.…”

Section: Resultsmentioning

confidence: 95%

The Relation Between Trace Element Status (Zinc, Copper, Magnesium) and Clinical Outcomes in COVID-19 Infection During Pregnancy

Anuk

Polat

Akdas

et al. 2020

Preprint

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Background: SARS CoV-2 is a novel coronavirus which cause recent pandemia and many deaths. This study aimed to determine zinc, copper and magnesium status on pregnant women with COVID-19.Methods: Totally 200 pregnants were included in the study, 100(34/33/33) were pregnants with COVID-19 infection and 100(33/32/35) were healthy pregnants and each group was divided into trimesters. Blood samples for trace element measurements were obtained from the patients along with the initial laboratory tests for clinical outcomes upon their first admission to hospital.Zinc, copper and magnesium levels were analyzed with atomic absorption spectroscopy.Results: In the first/third trimesters, serum zinc level was lower (p:0,004)/(p:0,02), serum copper level was higher (p:0,006)/(p:0,008), Zn/Cu ratio was decreased (p<0,0001)/(p<0,0001) and serum magnesium level was also higher (p<0,0001)/(p<0,0001) in COVID-19 group compared to control. Pregnants with COVID-19 in their second trimester had lower serum zinc level (p:0,05) and also copper level was decreased (p:0,0003) compared to control. Our correlation results showed that serum zinc and Zn/Cu ratio levels had negative relation with acute phase markers such as IL-6, Erythrocyte Sedimentation Rate, procalcitonin and Creactive Protein. Also, increased serum magnesium level might have role on decreased white blood cell, neutrophil, lymphocyte cell concentrations and there was correlation between serum magnesium and CRP level in the third trimester.Conclusion: This study indicated that trace element status changed in pregnants with COVID-19. With the further studies,it will be clarified that the effects of trace elements on COVID-19 in pregnant and in general population which was shown with this study first time to date.

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Potential Role of Serum Magnesium Measurement as a Biomarker of Acute Falciparum Malaria Infection in Adult Patients

Cited by 9 publications

References 19 publications

Assessment of the Antioxidant Status and Selected Electrolytes Level in Some Nigerian Malarial Patients: A Mini Comparative Study

Assessment of the Antioxidant Status and Selected Electrolytes Level in Some Nigerian Malarial Patients: A Mini Comparative Study

The Relation Between Trace Element Status (Zinc, Copper, Magnesium) and Clinical Outcomes in COVID-19 Infection During Pregnancy

The Relation Between Trace Element Status (Zinc, Copper, Magnesium) and Clinical Outcomes in COVID-19 Infection During Pregnancy

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