Potential role of differentially expressed lncRNAs in the pathogenesis of oral squamous cell carcinoma

Zhang, Shanchuan; Tian, Lili; Ma, Penghua; Sun, Qiang; Zhang, Kai; GuanchaoWang,; Liu, Hongchen; Xu, Baohua

doi:10.1016/j.archoralbio.2015.08.003

Cited by 42 publications

(49 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LINC00668 is a 1751‐bp lncRNA that maps to chromosome 18p11.31. In 2015, it was first reported to be overexpressed in OSCC (Zhang et al, ) and significantly associated with poor prognosis (Zhang, ). When compared to normal mucosa, OSCC tissue showed lower expression of miR‐297, negatively related to VEGFA expression.…”

Section: The Endogenous Rna Networkmentioning

confidence: 99%

“…In fact, miR‐224‐5p might act both as an oncogene in cervical cancer (Huang, Li et al, ) or as a tumour suppressor in both OSCC and breast cancer (Liu, Liu, Shen, Zhang, & Han, ; Zhang, ). Apart from miR‐224, FTH1P3 was found to be co‐expressed with PLAU (plasminogen activator, urokinase) a serine protease which may play an important role in the invasion and metastasis of malignant tumours (Zhang et al, ). PLAU has been reported to be upregulated in OSCC, and the product of the PLAU gene (uPA) and its receptor have been proven to be key regulators in cancer adhesion, migration and invasion (Laufs, Schumacher, & Allgayer, ).…”

Section: The Endogenous Rna Networkmentioning

confidence: 99%

“…PLAU has been reported to be upregulated in OSCC, and the product of the PLAU gene (uPA) and its receptor have been proven to be key regulators in cancer adhesion, migration and invasion (Laufs, Schumacher, & Allgayer, ). Other than FTH1P3, lncRNAs GIF2IRD2P1 and PDIA3P, which are differentially expressed in OSCC, are also predicted to target the PLAU gene (Zhang et al, ).…”

Section: The Endogenous Rna Networkmentioning

confidence: 99%

“…IL‐8 and NF‐kB both have a diversity of effectors, and downstream targets promoting angiogenic response, increase in proliferation, migration and survival of cancer cells. An analysis based on bioinformatic methods has shown that lncRNAs GIF2IRD2P1 and PDIA3P which are differentially expressed in OSCC, share among others, the same target genes of IL‐8 (Zhang et al, ).…”

Section: Ezh2 a Crossroad For Lncrna‐driven Interactions: Wnt/β‐catementioning

confidence: 99%

See 3 more Smart Citations

World Workshop on Oral Medicine VII: Functional pathways involving differentially expressed lncRNAs in oral squamous cell carcinoma

et al. 2019

View full text Add to dashboard Cite

Long non‐coding RNAs (lncRNA) modulate gene expression at the epigenetic, transcriptional and post‐transcriptional levels and are involved in tumorigenesis. They can form complex secondary and tertiary structures and have been shown to act as precursors, enhancers, reservoirs and decoys in the complex endogenous RNA network. They were first reported in relation to oral squamous cell carcinoma (OSCC) in 2013. Here, we summarise the functional roles and pathways of the most commonly studied lncRNAs in OSCC. Existing research demonstrates the involvement of lncRNA within pivotal pathways leading to the development and spread of OSCC, including interactions with key cancer‐associated microRNAs such as miR‐21. The number of studies on lncRNA and OSCC remains limited in this new field. As evidence grows, the tissue‐specific expression patterns of lncRNAs should further advance our understanding of the altered regulatory networks in OSCC and possibly reveal new biomarkers and therapeutic targets.

show abstract

Section: The Endogenous Rna Networkmentioning

confidence: 99%

Section: The Endogenous Rna Networkmentioning

confidence: 99%

Section: The Endogenous Rna Networkmentioning

confidence: 99%

Section: Ezh2 a Crossroad For Lncrna‐driven Interactions: Wnt/β‐catementioning

confidence: 99%

See 2 more Smart Citations

World Workshop on Oral Medicine VII: Functional pathways involving differentially expressed lncRNAs in oral squamous cell carcinoma

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Recently, lncRNAs have been reported as crucial for regulating cell development, growth, cell cycles, and cancer metastasis in human cancer [9]. Several aberrant lncRNAs were identified from high-throughput profiles and were associated with OSCC progression [10]. Fang et al reported that urothelial cancer associated 1 ( UCA1 ) is an overexpression in tongue squamous cell carcinomas (TSCCs) and may play an oncogenic role in tumorigenesis [11].…”

Section: Introductionmentioning

confidence: 99%

Aberrant DNA hypermethylation-silenced SOX21-AS1 gene expression and its clinical importance in oral cancer

et al. 2016

View full text Add to dashboard Cite

BackgroundLong noncoding RNAs (lncRNAs) are more than 200 nucleotides in length and lack transcriptional ability. The biological function of lncRNAs in oral squamous cell carcinoma (OSCC) remains unclear. The aim of this study was to identify the dysfunction of lncRNA in OSCC.ResultsWe analyzed the transcriptome profiles of human OSCC tissues and paired adjacent normal tissues from two patients through a next-generation sequencing approach. A total of 14 lncRNAs were upregulated (fold change ≥3) and 13 were downregulated (fold change ≤−3) in OSCC tissues compared with the adjacent normal tissues. SOX21-AS1 was subjected to further analysis, revealing that the expression levels of SOX21-AS1 significantly decreased in OSCC compared with the adjacent normal tissue. The promoter activity of SOX21-AS1 was obviously suppressed by in vitro methylation. The DNA methylation status of the SOX21-AS1 promoter was analyzed using combined bisulfite restriction analysis, revealing that the aberrant promoter hypermethylation of SOX21-AS1 was observed frequently in OSCC tissues. The effects of SOX21-AS1 on cell proliferation and invasion were examined through transient transfection. Our data showed that SOX21-AS1 could significantly suppress oral cancer cell growth and invasion. Furthermore, the low expression level of SOX21-AS1 was significantly correlated with an advanced stage (P = 0.047), large tumor size (P = 0.033), and poor disease-specific survival in OSCC patients (P = 0.002).ConclusionsSOX21-AS1 was identified as susceptible dysfunction correlated with promoter hypermethylation in OSCC. Low SOX21-AS1 expression may be an adverse prognostic biomarker for OSCC.Electronic supplementary materialThe online version of this article (doi:10.1186/s13148-016-0291-5) contains supplementary material, which is available to authorized users.

show abstract

Identification of 4‐lncRNA prognostic signature in head and neck squamous cell carcinoma

Diao

Song

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

Deregulated long noncoding RNAs (lncRNA) have been critically implicated in tumorigenesis and serve as novel diagnostic and prognostic biomarkers. Here we sought to develop a prognostic lncRNA signature in patients with head and neck squamous cell carcinoma (HNSCC). Original RNA-seq data of 499 HNSCC samples were retrieved from The Cancer Genome Atlas database, which was randomly divided into training and testing set. Univariate Cox regression survival analysis, robust likelihoodbased survival model and random sampling iterations were applied to identify prognostic lncRNA candidates in the training cohort. A prognostic risk score was developed based on the Cox coefficient of four individual lncRNA imputed as follows: (0.14546 × expression level of RP11-366H4.1) + (0.27106 × expression level of LINC01123) + (0.54316 × expression level of RP11-110I1.14) + (−0.48794 × expression level of CTD-2506J14.1). Kaplan-Meier analysis revealed that patients with high-risk score had significantly reduced overall survival as compared with those with lowrisk score when patients in training, testing, and validation cohorts were stratified into high-or low-risk subgroups. Multivariate survival analysis further revealed that this 4-lncRNA signature was a novel and important prognostic factor independent of multiple clinicopathological parameters.Importantly, ROC analyses indicated that predictive accuracy and sensitivity of this 4-lncRNA signature outperformed those previously well-established prognostic factors. Noticeably, prognostic score based on quantification of these 4-lncRNA via qRT-PCR in another independent HNSCC cohort robustly stratified patients into subgroups with high or low survival. Taken together, we developed a robust 4-lncRNA prognostic signature for HNSCC that might provide a novel powerful prognostic biomarker for precision oncology.

show abstract

Potential role of differentially expressed lncRNAs in the pathogenesis of oral squamous cell carcinoma

Cited by 42 publications

References 36 publications

World Workshop on Oral Medicine VII: Functional pathways involving differentially expressed lncRNAs in oral squamous cell carcinoma

World Workshop on Oral Medicine VII: Functional pathways involving differentially expressed lncRNAs in oral squamous cell carcinoma

Aberrant DNA hypermethylation-silenced SOX21-AS1 gene expression and its clinical importance in oral cancer

Identification of 4‐lncRNA prognostic signature in head and neck squamous cell carcinoma

Contact Info

Product

Resources

About