World Workshop on Oral Medicine VII: Functional pathways involving differentially expressed lncRNAs in oral squamous cell carcinoma

Pentenero, Monica; Bowers, Leah M.; Jayasinghe, Ruwan Duminda; Cheong, Sok Ching; Farah, Camile S.; Kerr, Alexander Ross; Alevizos, Ilias

doi:10.1111/odi.13051

Cited by 15 publications

(21 citation statements)

References 61 publications

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“…First identified long non-coding RNA, coded by gene H19 located in chromosome 11p15.5 in close association with insulin growth factor (IGF) 2 gene. LncRNA H19 is a transcription factor of the H19/IGF 2 genome blotting cluster, directly activated by c-MYC and down-regulated by p53 contributing to cell growth and proliferation [23].…”

Section: Lncrnas Upregulated During Oscc Progression A) Lncrna H19mentioning

confidence: 99%

“…MiRNA-138 and 630 down-regulate EZH2 and are suppressed by lncRNA H19. Thus H19 and Hox antisense intergenic RNA (HOTAIR) can up-regulate EZH2 decreasing the E-cadherin levels, enhancing the invasive potential of SCC cells with H19 expression being higher in metastatic tumors than nonmetastatic [23].…”

Section: Lncrnas Upregulated During Oscc Progression A) Lncrna H19mentioning

confidence: 99%

“…The domain 5' of HOTAIR binds PCR 2, which includes EZH2, SUZ 12, and EED (both polycomb proteins) to the HOX D locus and inhibits its expression. EZH2 is a histone H3 lysine 27 methyl transferase (H3K27me 3) enzyme that catalyzes trimethylation of H3K27, a histone modification associated with long-term transcription repression [23]. EZH2 is a critical epigenetic regulator for various biological processes such as cell proliferation, cell cycle, metastases, and oncogenesis [6,16].…”

Section: B) Hox Antisense Intergenic Rna-hotairmentioning

confidence: 99%

“…HOTAIR prefers to occupy a guanine-adenine (GA)-rich DNA motif on chromatin, which allows direct interaction of lncRNA transcript to specific genomic sites (has both cis and trans-regulatory mechanism) [20,23]. Also, the 3' domain of HOTAIR binds the histone demethylase lysine-specific histone demethylase (LSD)1.…”

Section: B) Hox Antisense Intergenic Rna-hotairmentioning

confidence: 99%

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Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas

Venugopal¹,

Bavle²,

Sudhakara³

et al. 2020

GJMR

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Non-coding ribonucleic acids (ncRNAs) are a class of RNA molecules that are transcribed but not translated into proteins, but they affect various cellular processes. Around 60% of genes in humans do not code proteins but regulate target gene expression. Presently, a lot of research is carried out on ncRNA involvement in oral squamous cell carcinoma (OSCC) and its precursor lesions termed as oral potentially malignant disorders (OPMDs). They are broadly classified as small ncRNAs (sncRNA) and long ncRNAs (lncRNA). sncRNAs are extensively studied, whereas the divulgence of lncRNAs in OSCCs needs more revelation, hence reviewed in the present article. LncRNAs have a base pair length of more than 200, can form complex structures and influence the gene expression in a multifaceted pattern that attracts interest.

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Section: Lncrnas Upregulated During Oscc Progression A) Lncrna H19mentioning

confidence: 99%

Section: Lncrnas Upregulated During Oscc Progression A) Lncrna H19mentioning

confidence: 99%

Section: B) Hox Antisense Intergenic Rna-hotairmentioning

confidence: 99%

Section: B) Hox Antisense Intergenic Rna-hotairmentioning

confidence: 99%

See 2 more Smart Citations

Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas

Venugopal¹,

Bavle²,

Sudhakara³

et al. 2020

GJMR

View full text Add to dashboard Cite

show abstract

“…These lncRNAs regulate molecular processes such cellular differentiation, apoptosis, angiogenesis, proliferation and inflammatory pathways which in turn lead to carcinogenesis [27]. The studies on the association between lncRNAs and addiction habits in head and neck cancer are still preliminary and sparse [28,29]. Recently, rs4759314 polymorphism present in the first intron of HOTAIR, contributes to an increased risk of HNC and serves as a potential biomarker [35].…”

Section: Overview Of Lncrnasmentioning

confidence: 99%

Long Non-Coding RNAs Emerging as Potential Epigenetic Biomarkers for Tobacco and/or Alcohol-Induced Head and Neck Cancer

Gupta

Kumar

Maini

et al. 2019

JCGB

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Head and Neck cancer (HNC) is one of the most prevalent and lethal cancer globally. The incidence of tobacco-induced HNC is gradually increasing in low and middle income countries. Among the various causative factors associated with HNCs, tobacco and alcohol play synergistic effect and are frequently associated with the risk of HNC. Tobacco-induced HNCs show distinct genetic and epigenetic alterations leading to different clinical outcomes in comparison to HPV-infected HNCs. Tobacco-induced HNCs are often associated with tumor aggressiveness, poor prognosis and low or nil prevalence of HPV infection. Apart from carcinogenic effects of these causative factors (use of tobacco products, alcohol intake and HPV or EBV infections), recent studies show that exposure to these factors alter/disrupt the regulation of non-coding RNAs including the long non-coding RNAs (lncRNAs). Altered lncRNA regulation is brought about by signalling networks that regulate cellular differentiation, apoptosis, angiogenesis and inflammatory pathways which play key functions in the genesis of different cancers including HNCs. There are numbers of studies supporting the emerging role of lncRNAs in development of HNC; however, reports connecting lncRNAs expression and addiction habits in HNC are still preliminary and sparse. Therefore, identification and characterization of lncRNAs that are differentially expressed upon exposure to risk-factors can serve as unique therapeutic targets and potential biomarker(s) for effective treatment of HNC subtypes. In this short review, we briefly reviewed the emerging role of lncRNAs in tobacco and alcohol induced HNCs.

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A novel lncRNA LOLA1 may predict malignant progression and promote migration, invasion, and EMT of oral leukoplakia via the AKT/GSK‐3β pathway

Liu¹,

Yao²,

Shi³

et al. 2021

J of Cellular Biochemistry

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Although dysregulation and dysfunction of long noncoding RNAs (lncRNAs) have been implicated in malignant behavior of oral squamous cell carcinoma (OSCC), whether aberrant lncRNAs play a role in the carcinogenesis of oral leukoplakia (OL) as the best-known precursor of OSCC remains undetermined. Differentially expressed lncRNAs in the occurrence and progression of OL were studied by microarray and quantitative reversetranscription polymerase chain reaction (qRT-PCR). We found a novel key lncRNA n386251 that we named LOLA1 (lncRNA oral leukoplakia progressed associated 1) in the OL progression. The results of qRT-PCR revealed that LOLA1 aberrant expression was validated in tissue samples and cell lines from the normal oral mucosa, OL to OSCC. Fluorescent in situ hybridization showed that LOLA1 expression localized predominately at the cytoplasm of Leuk1 cells. Cell function assays showed that LOLA1 significantly influenced cell migration, invasion, and epithelial-mesenchymal transition (EMT) protein expression. Potential mechanism experiments revealed that AKT/GSK-3β signaling was involved in the regulatory mechanism of LOLA1 in OL progression. Remarkably, Kaplan-Meier analysis revealed that LOLA1 overexpression could predict malignant events of OL progression to OSCC. In conclusion, the current study for the first time profiled and validated the key lncRNAs related to OL progression. Importantly, we demonstrated that a novel lncRNA LOLA1 upregulation was associated with OL malignant progression, suggesting LOLA1 may be a predictive biomarker. Moreover, LOLA1 may promote migration, invasion, and EMT process in OL malignant progression via AKT/GSK-3β pathway.

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World Workshop on Oral Medicine VII: Functional pathways involving differentially expressed lncRNAs in oral squamous cell carcinoma

Cited by 15 publications

References 61 publications

Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas

Eminence Grise of the Genome: Long Non-Coding Ribonucleic Acids in oral Squamous Cell Carcinomas

Long Non-Coding RNAs Emerging as Potential Epigenetic Biomarkers for Tobacco and/or Alcohol-Induced Head and Neck Cancer

A novel lncRNA LOLA1 may predict malignant progression and promote migration, invasion, and EMT of oral leukoplakia via the AKT/GSK‐3β pathway

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