Potential of triblock copolymers Pluronic® P-84 and F-108 with erythrosine B and its synthetic ester derivatives for photodynamic applications

Freitas, Camila Fabiano de; Rocha, Nicola Leone da; Pereverzieff, Isadora Simone; Batistela, Vagner Roberto; Malacarne, L. C.; Hioka, Noboru; Caetano, Wilker

doi:10.1016/j.molliq.2020.114904

Cited by 11 publications

(5 citation statements)

References 70 publications

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“…This group of copolymers is non-toxic, biocompatible, and has binding sites suitable for the solubilization of hydrophobic drugs [63]. In addition, triblock copolymers have a low critical micellar concentration (CMC, 10 −6 -10 −7 mol L −1 ) and the micelles formed to have high thermodynamic and kinetic stability, which guarantees a slow destructuring for unimers when they are exposed to an environment where the concentration is below the CMC [64,65]. Another factor to be considered for studies with polymeric surfactants is the temperature.…”

Section: Polymeric Nanoparticles: Copolymeric Micellar Systems In Dru...mentioning

confidence: 99%

“…Another factor to be considered for studies with polymeric surfactants is the temperature. The micellization process will only occur above a specific critical micellar temperature (CMT), which, in turn, is a function of the surfactant concentration [64,65]. In addition, there is evidence that temperature increases also cause an increase in the aggregation number (N ag ) of the copolymers [64].…”

Section: Polymeric Nanoparticles: Copolymeric Micellar Systems In Dru...mentioning

confidence: 99%

“…In addition, there is evidence that temperature increases also cause an increase in the aggregation number (N ag ) of the copolymers [64]. Therefore, to be effective, the polymer used to obtain the micelle must present CMT compatible with the conditions necessary for the application [65].…”

Section: Polymeric Nanoparticles: Copolymeric Micellar Systems In Dru...mentioning

confidence: 99%

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Phenazines and Photoactive Formulations: Promising Photodrugs for Photodynamic Therapy

Júnior¹,

Campanholi²,

Morais³

et al. 2023

Dyes and Pigments - Insights and Applications

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Photodynamic Therapy (PDT) is a therapeutic modality that can be applied with many photosensitizing compounds (PS). Photosensitization has shown promising results in damage against abnormal cell growth as cancer and inactivating a broad spectrum of microorganisms with no reported microbial resistance. Photodynamic processes occur by the light action at the appropriate wavelength in the presence of a PS that will be excited by the energy absorbed from the light source, where the interaction with the oxygen present in the cell will generate reactive oxygen species (ROS). The potential of phenazines as a photosensitizer is reviewed in this chapter as a practical guide to the future development of formulations that are effective for cancer treatment and microorganism control. Here we mainly summarize articles about phenazines from 2005 to 2021 when we performed a systematic search in the Science Direct, PubMed, Google Scholar, Web of Science, and Scopus databases. The carrier systems formed by micellar copolymers type Pluronic® have demonstrated effectiveness in incorporating several PS, ensuring its monomeric form for PDT applications. The fundamentals of the photosensitization mechanism are discussed. Studies have shown the beneficial impact of an appropriate incorporation technique to enhance the cellular uptake of phenazines compounds.

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Section: Polymeric Nanoparticles: Copolymeric Micellar Systems In Dru...mentioning

confidence: 99%

Section: Polymeric Nanoparticles: Copolymeric Micellar Systems In Dru...mentioning

confidence: 99%

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Phenazines and Photoactive Formulations: Promising Photodrugs for Photodynamic Therapy

Júnior¹,

Campanholi²,

Morais³

et al. 2023

Dyes and Pigments - Insights and Applications

Self Cite

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“…Along with other pK a -probes, dyes of the fluorescein series are used to understand micellar solutions and related systems [7,8,[12][13][14][15][16][17]. Their fluorescence can be used as an additional source of information on the properties of surfactant micelles [18,19].…”

Section: Introductionmentioning

confidence: 99%

“…It is of interest to study such dye + micelle systems, which are of practical importance and at the same time allow us to expand our knowledge of the properties of dyes. The most widely studied and applied are fluorescein and its halogen derivatives [14,[16][17][18][19][20][21][22][23][26][27][28][30][31][32]39]. Some new properties of nitro derivatives [15,29,37,38,46,47] and thio analogues of fluorescein [48] have been also described.…”

Section: Introductionmentioning

confidence: 99%

Protolytic Equilibria in Organized Solutions: Ionization and Tautomerism of Fluorescein Dyes and Related Indicators in Cetyltrimethylammonium Chloride Micellar Solutions at High Ionic Strength of the Bulk Phase

Mchedlov‐Petrossyan

Vodolazkaya

2021

Liquids

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Ionic equilibrium of 22 hydroxyxanthenes, including halogen and nitro derivatives of fluorescein, and their thio- and aza analogues, were studied spectrophotometrically in micellar solutions of cetyltrimethylammonium chloride at ionic strength of the bulk phase 4.0 M KCl. This micellar pseudophase is characterized by the electrostatic surface potential of +(15–16) mV and the ETN value of 0.623. In the case of dyes bearing the COOH group, colorless lactone is the predominant tautomer of the molecular form H2R. A new classification of fluoresceins is developed. The dyes were divided into four groups based on the nature of tautomerism of the anions. In the case of the fluorescein type, the monoanions HR− exist predominantly as “carboxylate” tautomers, with ionized carboxylic and non–ionized hydroxylic group. For the dyes of the eosin type, the situation is opposite, while for the intervening type of compounds, the concentrations of the two tautomers are comparable. Dyes capable of forming lactone anions HR− were classified as the fourth type. For some of them, even the dianion R2− exists as a lactone. The relationship between the stepwise ionization constants, Ka1/Ka2, varies from 1.3 to 1.07 × 105 and is determined by the state of tautomeric equilibrium of molecules and ions.

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Comprehensive review of Pluronic® polymers of different shapes with prominent applications in photodynamic therapy

Kumar,

Harikrishnan,

Urmila

et al. 2023

European Polymer Journal

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Potential of triblock copolymers Pluronic® P-84 and F-108 with erythrosine B and its synthetic ester derivatives for photodynamic applications

Cited by 11 publications

References 70 publications

Phenazines and Photoactive Formulations: Promising Photodrugs for Photodynamic Therapy

Phenazines and Photoactive Formulations: Promising Photodrugs for Photodynamic Therapy

Protolytic Equilibria in Organized Solutions: Ionization and Tautomerism of Fluorescein Dyes and Related Indicators in Cetyltrimethylammonium Chloride Micellar Solutions at High Ionic Strength of the Bulk Phase

Comprehensive review of Pluronic® polymers of different shapes with prominent applications in photodynamic therapy

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