Potential of Teucrium chamaedrys L. to modulate apoptosis and biotransformation in colorectal carcinoma cells

Morphology and phytochemistry of Teucrium chamaedrys L. (Lamiaceae) cultivated at the Ghirardi Botanic Garden (Lombardy, Northern Italy)

“…Furthermore, the composition of the essential oils from aerial parts of T. chamaedrys of different origins was analysed (Bezić et al, 2011;Djabou et al, 2013b;Hajdari et al, 2020;Kaya et al, 2009;Sajjadi and Shookohinia, 2010). Polar extracts were also examined (Gafner et al, 2003;Frezza et al, 2018;Milutinović et al, 2019), often in association with their biological activities, including antimicrobial (Djabou et al, 2013b) and antiphytoviral (Bezić et al, 2011), along with cytotoxic and pro-apoptotic effects in colorectal cancer cells (Milutinović et al, 2019). Despite the wide traditional uses of T. chamaedrys, several works documented some risks of hepatotoxicity related to the content of furanoneocloredane diterpenes, especially teucrin A (Bosisio et al, 2004;Nencini et al, 2014).…”

Colicins and Microcins Produced by Enterobacteriaceae: Characterization, Mode of Action, and Putative Applications

“…Among them, secondary metabolites produced by plants or fungi constitute a relevant source of promising anticancer agents [ 105 , 106 , 107 , 108 , 109 ]. Additionally, it has been reported that proteins from other natural sources, such as animal venoms or protein structure such as fibroin and sericin from insects’ silk, also show selective anticancer and proapoptotic activity [ 110 , 111 , 112 ]. Another promising area of research involves the study of therapeutic peptides and proteins, including bacteriocins, produced by bacteria, due to their ability to affect cancer cells [ 113 , 114 , 115 ].…”

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

“…The extrinsic pathway is initiated by the TNF (tumor necrosis factor), TRAIL (TNF-related apoptosis-inducing ligand), and Fas ligands binding to the extracellular domain of death receptors, such as type 1 TNF receptor (TNFR1), TRAIL, and Fas receptors. The Teucrium chamaedrys aerial flowering part extract initiated an excessive expression of Fas in SW480 cells [ 170 ]. The Fas ligand–receptor junction is inhibited by nucleolin, which is a protein that protects against apoptotic death [ 175 ].…”

“…Cytochrome c binds to apoptotic protease-activating factor 1 (Apaf-1) to create an apoptosome that activates caspase-9. Caspase-9 was found to be upregulated following treatment with Coleus amboinicus leaf extract in WiDr cells [167], Teucrium sandrasicum leaf extract in MCF-7 cells [163], Vitex rotundifolia leaf extract in T-47D cells [159], Micromeria fruticose aerial part extract in MCF-7 cells [144], Stachys pilifera leaf extract in HT-29 cell line [154], and Teucrium chamaedrys aerial and flowering parts in SW480 cells [170].…”

“…The attachment of a Fas to a specific receptor triggers the formation of specific death-inducing signaling complex (DISC) possessing a Fas-associated death domain (FADD); this complex can recruit an adaptor protein and then activate initiator caspase-8 and caspase-10. Caspase-8 induction was found to induce apoptosis in MCF-7 and HCT-116 cells following Micromeria fruticose aerial part extract administration [144], as well as treatment with Vitex rotundifolia leaf extract in T-47D cells [159], Stachys pilifera leaf extract in the HT-29 cell line [154], and for Teucrium chamaedrys aerial flowering part extract in SW480 cells [170]. In addition, it was speculated that Satureja khuzistanica extract enriched in rosmarinic acid can induce apoptosis through activation of the extrinsic pathway in MCF-7 cells [151].…”