Potential of propolis antifungal activity for clinical applications

Abstract

The high incidence of skin diseases of microbial origin along with the widespread increase of microbial resistance demand for therapeutic alternatives. Research on natural compounds has been opening new perspectives for the development of new therapies with health-positive impacts. Propolis, a resinous mixture produced by honeybees from plant exudates, is widely used as a natural medicine since ancient times, mainly due to its antimicrobial properties. More recently, antioxidant, antitumour, anti-inflammatory, hepatoprotective and immunomodulatory activities were also reported for this natural product, highlighting its high potential pharmacological interest. In the present work, an extensive review of the main fungi causing skin diseases as well as the effects of natural compounds, particularly propolis, against such disease-causing micro-organisms was organized and compiled in concise handy tables. This information allows to conclude that propolis is a highly effective antimicrobial agent suggesting that it could be used as an alternative skin treatment against pathogenic micro-organisms and also as a cosmeceutical component or as a source of bioactive ingredients.

Evaluación Microbiológica De La Vida Útil De Néctar De Durazno Con Propóleo Como Conservante Natural

“…Sacc., detiene el crecimiento del micelio y actúa sobre la respiración del patógeno y la homeostasis energética, siendo estos efectos atribuidos a la presencia de pinocembrina (Anjum et al, 2019). El propóleo también ha demostrado actividad antimicotica contra diferentes especies de levaduras, entre ellas las del género Candida, siendo en este efecto asociado a la gran cantidad de flavonoides que presenta, además de otros componentes clave involucrados en esta actividad como 3-acetilpinobanskin, pinobanksin-3acetato, pinocembrina, ácido p -cumárico y ácido cafeico (Cerqueira et al, 2022).…”

A novel black poplar propolis extract with promising health-promoting properties: focus on its chemical composition, antioxidant, anti-inflammatory, and anti-genotoxic activities

“…Overall, the reported biological activities of propolis include antibacterial, 26,27 antiviral, 28 antifungal, 29 anti-parasitic, 30 anti-oxidant, 31,32 anti-inflammatory, 33 and anti-cancer. 34,35…”

“…25 In modern times, propolis is applied for various purposes in addition to human medicine, such as cosmetics, the food industry and aquaculture as well as in livestock farming. 5 Overall, the reported biological activities of propolis include antibacterial, 26,27 antiviral, 28 antifungal, 29 anti-parasitic, 30 anti-oxidant, 31,32 anti-inflammatory, 33 and anti-cancer. 34,35 The first scientific study involving propolis, which covered its chemical properties and composition, was published in 1908.…”

Antifungal Activity of Mexican Propolis on Clinical Isolates of Candida Species

“…Throughout history, human beings have used natural products such as propolis to alleviate diseases of different etiologies [ 1 ]. In its extensive period of use, propolis has been used for the treatment of bacterial [ 2 , 3 ], fungal [ 4 , 5 ], viral [ 6 , 7 ], and parasitic infections [ 8 , 9 ]. At present, it is well known that it possesses anti-inflammatory [ 10 , 11 ], antitumor [ 12 , 13 ], antidiabetic [ 14 , 15 ], and immunomodulatory properties [ 16 , 17 ]; however, it is its antioxidant effect that stands out and is maintained in most types of propolis from different countries [ 18 , 19 , 20 ].…”