Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals

Geßner, Denise K.; Ringseis, Robert; Eder, Klaus

doi:10.1111/jpn.12579

Cited by 249 publications

(235 citation statements)

References 201 publications

(268 reference statements)

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“…Treating macrophages with OBE before the stimulation with LPS partly counteracted such responses by about 30%. These results are similar to findings from recent studies demonstrating anti-inflammatory properties of polyphenols and other plant bioactives in cell cultures [52; 53] and farm animals [54]. Furthermore, our in vivo and in vitro results indicate that inhibition of IL1B production is a key component of the OBE anti-inflammatory action.…”

Section: Discussionsupporting

confidence: 92%

Olive oil bioactives protect pigs against experimentally-induced chronic inflammation independently of alterations in gut microbiota

Liehr

Mereu²,

Pastor³

et al. 2017

PLoS ONE

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Subclinical chronic inflammation (SCI) is associated with impaired animal growth. Previous work has demonstrated that olive-derived plant bioactives exhibit anti-inflammatory properties that could possibly counteract the growth-depressing effects of SCI. To test this hypothesis and define the underlying mechanism, we conducted a 30-day study in which piglets fed an olive-oil bioactive extract (OBE) and their control counterparts (C+) were injected repeatedly during the last 10 days of the study with increasing doses of Escherichia coli lipopolysaccharides (LPS) to induce SCI. A third group of piglets remained untreated throughout the study and served as a negative control (C-). In C+ pigs, SCI increased the circulating concentration of interleukin 1 beta (p < 0.001) and decreased feed ingestion (p < 0.05) and weight gain (p < 0.05). These responses were not observed in OBE animals. Although intestinal inflammation and colonic microbial ecology was not altered by treatments, OBE enhanced ileal mRNA abundance of tight and adherens junctional proteins (p < 0.05) and plasma recovery of mannitol (p < 0.05) compared with C+ and C-. In line with these findings, OBE improved transepithelial electrical resistance (p < 0.01) in TNF-α-challenged Caco-2/TC-7 cells, and repressed the production of inflammatory cytokines (p < 0.05) in LPS-stimulated macrophages. In summary, this work demonstrates that OBE attenuates the suppressing effect of SCI on animal growth through a mechanism that appears to involve improvements in intestinal integrity unrelated to alterations in gut microbial ecology and function.

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Section: Discussionsupporting

confidence: 92%

Olive oil bioactives protect pigs against experimentally-induced chronic inflammation independently of alterations in gut microbiota

Liehr

Mereu²,

Pastor³

et al. 2017

PLoS ONE

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“…Epigallocatechin gallate (EGCG), the most active substance in tea polyphenols, demonstrates the strong antioxidant activity and antiinflammatory capacity (Gessner, Ringseis, & Eder, 2017). Extensive research performed in recent years has revealed that EGCG exhibits a strong antioxidant capacity to mitigate the effects of heat stress on growth performance (Luo et al, 2018;Orhan et al, 2013) and meat quality (Huang, Zhang, Zhou, Wan, & Zhang, 2015;Zhang et al, 2012) in poultry.…”

Section: Introductionmentioning

confidence: 99%

The effect of Epigallocatechin‐3‐gallate on small intestinal morphology, antioxidant capacity and anti‐inflammatory effect in heat‐stressed broilers

Song

Lei

Luo

et al. 2019

Animal Physiology Nutrition

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This study was to investigate the effects of Epigallocatechin‐3‐gallate (EGCG) on intestinal morphology, antioxidant capacity and anti‐inflammatory response in heat‐stressed broiler. A total of 192 2‐week‐old Arbour Acres broilers chickens were divided into four groups with six replicates per group and eight chickens per replicate: one thermoneutral control group (28°C, group TN), which was fed the basal diet; and three cyclic high‐temperature groups (35°C from 7:00 to 19:00 hr; 28°C from 19:00 hr to 7:00 hr, heat stress group), which were fed the basal diet supplementation with EGCG 0 mg/kg (group HS0), 300 mg/kg (group HS300) and 600 mg/kg (group HS600). The gut morphology and intestinal mucosal oxidative stress indicators, as well as intestinal barrier‐related gene expression, were analysed. The results showed that compared with group TN, heat stress reduced the villus height (VH), activities of glutathione peroxidase (GSH‐Px), superoxide dismutase (SOD)and catalase (CAT), increased the crypt depth (CD) and malondialdehyde (MDA)content at 21, 28 and 35 days (p < 0.05). After the heat‐stressed broilers were supplemented with EGCG, VH, VH/CD (V/C), and the activities of GSH‐Px, SOD and CAT were increased, and CD and MDA content were reduced compared with those in group HS0 without EGCG supplementation at 21, 28 and 35 days (p < 0.05). The EGCG supplementation promoted the gene expression of nuclear factor‐erythroid 2‐related factor 2 (Nrf2), Claudin‐1, Mucin 2 (Muc2) and alleviated the nuclear factor‐kappa B (NF‐κB) and lipopolysaccharide‐induced tumour necrosis factor (LITAF) gene expression compared with group HS0 (p < 0.05). Moreover, intestinal morphology was strongly correlated with antioxidant ability and inflammatory response. In conclusion, EGCG alleviated the gut oxidative injury of heat‐stressed broilers by enhancing antioxidant capacity and inhibiting inflammatory response.

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“…However, as mRNA concentrations of these genes were not statistically significant different between the two groups of cows, the effect of polyphenols on hepatic inflammation and ER stress remains unclear. As polyphenols are exerting a broad spectrum of metabolic effects [14–16], we hypothesized that feeding of GSGME might influence other metabolic pathways in the liver which could account for the positive effects of GSGME observed in cows during early lactation. In order to investigate this hypothesis, we used a genome-wide transcript profiling technique to explore changes in the hepatic transcriptome of cows supplemented with GSGME during the transition period.…”

Section: Introductionmentioning

confidence: 99%

Analysis of hepatic transcript profile and plasma lipid profile in early lactating dairy cows fed grape seed and grape marc meal extract

Geßner

Winkler²,

Koch

et al. 2017

BMC Genomics

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BackgroundIt was recently reported that dairy cows fed a polyphenol-rich grape seed and grape marc meal extract (GSGME) during the transition period had an increased milk yield, but the underlying reasons remained unclear. As polyphenols exert a broad spectrum of metabolic effects, we hypothesized that feeding of GSGME influences metabolic pathways in the liver which could account for the positive effects of GSGME in dairy cows. In order to identify these pathways, we performed genome-wide transcript profiling in the liver and lipid profiling in plasma of dairy cows fed GSGME during the transition period at 1 week postpartum.ResultsTranscriptomic analysis of the liver revealed 207 differentially expressed transcripts, from which 156 were up- and 51 were down-regulated, between cows fed GSGME and control cows. Gene set enrichment analysis of the 155 up-regulated mRNAs showed that the most enriched gene ontology (GO) biological process terms were dealing with cell cycle regulation and the most enriched Kyoto Encyclopedia of Genes and Genomes pathways were p53 signaling and cell cycle. Functional analysis of the 43 down-regulated mRNAs revealed that a great part of these genes are involved in endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) and inflammatory processes. Accordingly, protein folding, response to unfolded protein, unfolded protein binding, chemokine activity and heat shock protein binding were identified as one of the most enriched GO biological process and molecular function terms assigned to the down-regulated genes. In line with the transcriptomics data the plasma concentrations of the acute phase proteins serum amyloid A (SAA) and haptoglobin were reduced in cows fed GSGME compared to control cows. Lipidomic analysis of plasma revealed no differences in the concentrations of individual species of major and minor lipid classes between cows fed GSGME and control cows.ConclusionsAnalysis of hepatic transcript profile in cows fed GSGME during the transition period at 1 week postpartum indicates that polyphenol-rich feed components are able to inhibit ER stress-induced UPR and inflammatory processes, both of which are considered to contribute to liver-associated diseases and to impair milk performance in dairy cows, in the liver of dairy cows during early lactation.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-017-3638-1) contains supplementary material, which is available to authorized users.

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Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals

Cited by 249 publications

References 201 publications

Olive oil bioactives protect pigs against experimentally-induced chronic inflammation independently of alterations in gut microbiota

Olive oil bioactives protect pigs against experimentally-induced chronic inflammation independently of alterations in gut microbiota

The effect of Epigallocatechin‐3‐gallate on small intestinal morphology, antioxidant capacity and anti‐inflammatory effect in heat‐stressed broilers

Analysis of hepatic transcript profile and plasma lipid profile in early lactating dairy cows fed grape seed and grape marc meal extract

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