Potential of a simplified measurement scheme and device structure for a low cost label-free point-of-care capacitive biosensor

Vasconcelos, Elder A. de; Peres, Newton G.; Pereira, Cintya O.; Silva, Valdinete L. da; Silva, Eronides F. da; Dutra, Rosa F.

doi:10.1016/j.bios.2009.08.050

Cited by 64 publications

(41 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…the immunocomplex formed onto the electrodes increases the capacitance in low frequencies that allows the use of low-cost capacitance meters for the measurement. With further optimizations and improvements in the device structure, this label-free technology may be feasible for low-resource settings as the preliminary assay with cardiac troponin T demonstrating sensivity in clinically relevant range [82].…”

Section: Electrochemical Detectionmentioning

confidence: 99%

Simple and inexpensive immunoassay-based diagnostic tests

Päkkilä

Soukka

2011

Bioanal Rev

View full text Add to dashboard Cite

Simple and inexpensive yet sensitive and robust diagnostic tests are critically needed for resource-poor settings to enable timely diagnosis and effective use of limited health care resources. Current tests are often too expensive, too slow, or have compromised clinical performance, and they often require health care professional to perform the test. In addition, most assays are not intended to be used in extreme environmental conditions, but their performance may be affected by high temperatures and humidity often encountered in resource-poor settings. This review provides an overview of current immunoassay technologies and their advantages and limitations with respect to their feasibility to resourcepoor settings. Future trends of immunoassay development for decentralized testing are also discussed. Homogeneous assays as such are out of the scope of this article because they are generally not yet sensitive enough or otherwise less feasible for inexpensive rapid diagnostic tests.

show abstract

Section: Electrochemical Detectionmentioning

confidence: 99%

Simple and inexpensive immunoassay-based diagnostic tests

Päkkilä

Soukka

2011

Bioanal Rev

View full text Add to dashboard Cite

show abstract

“…Changes in dielectric properties of the measurement basis on or load distribution depend on the conductivity change in the exchange of antigen-antibody interaction on the surface of the electrode. Recently, the label was developed the redox mediator used in capacitive biosensors in this system (Carrara et al, 2009;de Vasconcelos et al, 2009;Saravan et al, 2008). In this study, the covalent bonding on an optimized GID is connected antibodies via epoxy-silanisation (Saravan et al 2008), this method is less prone to sensitivity, the other less cheap silicon dioxide with a high-sensitive measurement applied to nanocrystalline diamonds (Quershi et al , 2009).…”

Section: Electrochemical Immunosensors Developed For the Detection Ofmentioning

confidence: 99%

Biosensors for Cancer Biomarkers

Uygun¹,

Sezgintürk²

2011

Biosensors - Emerging Materials and Applications

View full text Add to dashboard Cite

“…al. reported an immunosensor for cardiac biomarker, for cardiac troponin T (cTnT) based on capacitive changes after antigen binding on two planar aluminum electrodes separated by a distance of 2 mm with a detection limit down to sub ng ml −1 levels [68]. Recently, Chuang et.…”

Section: Non-faradaic Impedance Immunosensorsmentioning

confidence: 99%