Potential drug–drug interactions in the medication of medical patients at hospital discharge

Abstract

Using a computerised drug-interaction program, a high proportion of patients was detected with at least one potential DDI in the medication prescribed at discharge. However, the proportion of DDIs associated with potentially relevant clinical consequences appeared to be relatively low.

Potential Drug-Drug Interactions in Psychiatric Ward of a Tertiary Care Hospital: Prevalence, Levels and Association with Risk Factors

“…The results of our study show that the prevalence of pDDIs in the psychiatric ward (64.8%) was higher compared to other hospitalized patients (49.7 % [3] and 27.8 % [2]) or patients of other wards such as internal medicine wards (51 % [4] and 60 % [13] ) and oncology wards (63 % [5]). In our study, prevalence of pDDIs of major severity (27.2 %) was also higher compared to other studies.…”

“…We recorded average 1.98 and median number of 1 pDDI per patient in our study. Average 1.44 pDDIs per patient was reported by Fokter et al [4] and median pDDIs of 2 per patient was estimated by Egger et al [13]. Vasudev and Harrison demonstrated a high prevalence of pDDIs (96 %) in psychiatric wards [14]; Janchawee et al reported the highest prevalence of pDDIs in psychiatric prescriptions (57.8 %) compared to internal medicine (42.4 %), pediatrics (13.1 %) and surgery (23.3 %) [18].…”

“…In comparison to other clinical specialty wards, e.g., internal medicine wards [4,12,13], very few studies have addressed the issue of DDIs in psychiatric wards. A small scale cross-sectional survey (n = 48), conducted in elderly psychiatric wards identified a total of 152 pDDIs in 96 % (46/48) of prescriptions [14].…”

Drug interactions and adverse events associated with antimycotic drugs used for invasive aspergillosis in hematopoietic SCT

“…In patients in medical wards, prevalence estimates for pDDIs assessed for all drugs prescribed were up to 68%. [33][34][35] Of the 57 pDDIs found in our study, 7 and 26% resulted in ADEs with a probable and possible causality, respectively. In a retrospective study including patients from an intensive care and an infectious disease unit, a total of 116 pDDIs were recorded in 150 antimycotic treatment episodes with amphotericin B, fluconazole, itraconazole and flucytosine.…”

Discontinuities in drug use upon hospital discharge

“…Previously published research has demonstrated that drug use several weeks after discharge often deviates from the drug treatment at the moment of discharge 6,7 . Drug-drug interactions with combinations that potentially may result in major clinical consequences at discharge are frequently the result of changes of the prescription medication during hospitalisation 8 . Little research, however, has been conducted on the conformity of drug use in the hospital and the drugs delivered at the moment of discharge.…”