Potential Compound Derived From Catharanthus Roseus to Inhibit Non Small Cell Lung Cancer (Nsclc)

Senthilraja, P.; Kayitare, John; Manivel, Gowdham; Manikandaprabhu, S.; Krishnamurthy, Anand

doi:10.7897/2277-4343.06254

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Furthermore, It also has been used internally for hypertension, loss of memory, cystitis, enteritis and gastritis, raised blood sugar levels, and diarrhea 2 . This plant produces a diverse array of secondary metabolites that are pharmaceutically important and used as chemotherapeutic agents in the treatment of several types of cancers 3 .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Pharmacognostic Study of Catharnthus Roseus Using Deep Eutectic Solvents

Nisar¹,

Mamat²,

Hatim³

et al. 2016

Int. J. Res. Ayurveda Pharm.

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Medicinal plant derived compound have an important role in the development of many clinically useful agents. Catharanthus roseus is a significant medicinal plant of the Apocynaceae family. Catharanthus roseus plant is used for different disease treatment such as skin cancer, Hodgkin's disease, breast cancer, and lymphoblastic leukemia. The aim of this study is conferring the comparative abundances of different phytochemicals, physiochemical and fluorescence analysis from Catharanthus roseus. Some of the chemical constituent's tests have been performed for phytochemical analysis. Fluorescence analysis was done by using dried powder mixed with different chemicals and have been observed under UV light (365 nm) and ordinary light. Total ash, acid insoluble ash, and moisture have been selected for physiochemical analysis. The precipitate formation or colour change was used as analytical answers for phytochemical analysis. The result of fluorescence analysis observed under UV light (365nm) and ordinary light by observing colour changes in sample. The percentage of loss of weight on drying, total ash and acid insoluble ash were obtained by employing standard methods of analysis for the physiochemical test. Extraction of Catharanthus roseus plant using deep eutectic solvent gave positive results.

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Section: Introductionmentioning

confidence: 99%

Phytochemical and Pharmacognostic Study of Catharnthus Roseus Using Deep Eutectic Solvents

Nisar¹,

Mamat²,

Hatim³

et al. 2016

Int. J. Res. Ayurveda Pharm.

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“…GC-MS chromatogram of algal hot water extract also revealed the presence of a secondary metabolite, 2H-Pyran, tetrahydro-2-(12-pentadecynyloxy, with a percentage of 3.7. This secondary metabolite has potential application as an inhibitor to non-small cell lung cancer as well as antibacterial and antioxidant activities [ 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Volatile Compounds, Fatty Acids Constituents, and Antimicrobial Activity of Cultured Spirulina (Arthrospira fusiformis) Isolated from Lake Mariout in Egypt

Hamad

El-Baky

Sharaf

et al. 2023

The Scientific World Journal

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In this study, Arthrospira fusiformis previously isolated from Lake Mariout (Alexandria, Egypt) was cultivated in the laboratory using a medium for pharmaceutical grade Arthrospira, named as Amara and Steinbüchel medium. Hot water extract of the Egyptian Spirulina was prepared by autoclaving dried biomass in distilled water at 121°C for 15 min. This algal water extract was analyzed by GC-MS to evaluate its volatile compounds and fatty acids composition. The antimicrobial activity of phycobiliprotein extract from Arthrospira fusiformis using phosphate buffer was evaluated against thirteen microbial strains (two Gram-positive bacteria, eight Gram-negative bacteria, one yeast, and two filamentous fungi). The major components of fatty acids in the hot extract of Egyptian A. fusiformis were hexadecanoic acid (palmitic acid, 55.19%) and octadecanoic acid (stearic acid, 27.14%). The main constituents of its volatile compounds were acetic acid (43.33%) and oxalic acid (47.98%). The most potent antimicrobial effect of phycobiliprotein extract was obtained against two Gram-negative bacteria Salmonella typhi and Proteus vulgaris, filamentous fungus Aspergillus niger, and the pathogenic yeast Candida albicans (all of which showed MIC values of 58.1 μg/ml). Escherichia coli and Salmonella typhimurium come second in their susceptibility to the phycobiliprotein extract from Arthrospira fusiformis and Serratia marcescens and Aspergillus flavus are the least in susceptibility, with MIC values of 116.2 and 232.5 μg/ml, respectively, while phycobiliprotein extract has no antibacterial effect on methicillin-resistant as well as susceptible Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Shigella sonnei. These findings confirmed the nutritional value of Egyptian A. fusiformis isolated from Lake Mariout and suggest the potential use of this strain as an ingredient in the cooking of some foods to increase the level of stearic acid and palmitic acid. Moreover, its effective antibacterial activities against some important and highly resistant to antibiotics bacterial pathogens in addition to its antifungal effects recommend the therapeutic use of its biomass.

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Targeting Arachidonic Acid Pathway-Associated NF-κB in Pancreatic Cancer

Yarla

Sukocheva

Peluso

et al. 2017

Role of Transcription Factors in Gastrointestinal Malignancies

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Potential Compound Derived From Catharanthus Roseus to Inhibit Non Small Cell Lung Cancer (Nsclc)

Cited by 5 publications

References 30 publications

Phytochemical and Pharmacognostic Study of Catharnthus Roseus Using Deep Eutectic Solvents

Phytochemical and Pharmacognostic Study of Catharnthus Roseus Using Deep Eutectic Solvents

Volatile Compounds, Fatty Acids Constituents, and Antimicrobial Activity of Cultured Spirulina (Arthrospira fusiformis) Isolated from Lake Mariout in Egypt

Targeting Arachidonic Acid Pathway-Associated NF-κB in Pancreatic Cancer

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