Potential biomarkers for the cytologic diagnosis of oral squamous cell carcinoma

Yang, Wei; Chung, Ho Ren; Wu, Jia Yo; Chen, Yi; Wang, Duen Jeng; Lee, Sheng Yang

doi:10.1016/s1991-7902(10)60010-4

Cited by 5 publications

(4 citation statements)

References 120 publications

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“…Oral cancer is the 11th most common malignancy in the world (Ghantous and Abu Elnaaj, 2017) and is the most common head and neck malignant tumors that has a high mortality rate. The most common type of oral cancer is Oral Squamous Cell Carcinoma (OSCC), which includes for approximately 90% of oral malignancies (Franzmann since fifty years ago and this is maybe due to the fact that OSCC patients are diagnosed at late stages, and there is no reliable and definitive diagnostic marker for early diagnosis of this disease (Yang et al, 2010). Currently, OSCC is diagnosed usually in stages III and IV, with less effective treatment and a therapeutic success of 30%.…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly OSCC is less detected in the early stages; early diagnosis by screening will be an obvious solution (Franzmann et al, 2005). Therefore, the use of sensitive and specific biomarkers for molecular detection along with histological sampling would be a convenient, accessible, non-invasive and inexpensive method for OSCC diagnosis (Yang et al, 2010. It seems that ELISA-based techniques as a screening tool for society are the most cost-effective methods; because its implementation is simpler and cheaper than DNA-based techniques (Franzmann et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…3-The benefits of screening should be greater than the potential of its losses and costs. 4-The screening tests should definitely diagnose the disease in the early stages (Franzmann et al, 2005, Yang et al, 2010. Based on our knowledge about OSCC and the results of previous studies (Franzmann et al, 2005) and (Franzmann et al, 2007), it seems that the evaluation of CD44 in serum and saliva can be as a effective community screening tool for the early diagnosis of OSCC.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Salivary and Serum Soluble CD44 Levels between Patients with Oral SCC and Healthy Controls

Seyedmajidi

Foroughi

et al. 2018

Asian Pac J Cancer Prev

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Background:The most common type of oral cancer is oral squamous cell carcinoma. If it is diagnosed in the early stages; the success of the treatment can be increased. It seems that ELISA-based techniques as a screening tool for society are the most cost-effective methods for early diagnosis. CD44 is a key marker for the detection of SCC stem cells. The aim of this study was to compare the level of soluble CD44 in saliva and serum between patients with oral SCC and healthy controls.Materials and Methods:Saliva and serum were collected from 20 patients with primary OSCC and 20 healthy persons as control group. The samples were evaluated by an ELISA test kit. Data were analyzed by SPSS software version 22, chi-square, ANOVA, T-test and Spearman correlation test.Results:The mean of soluble CD44 level in serum and saliva of the patient and control groups are 531.51±228.95 and 453.3±113.74 (for serum) and 48.53±59.02 and 17.76±39.14 (for saliva) respectively. There was no statistically significant difference in serum and saliva solCD44 level between the patient and control groups (P value = 0.182 and P value = 0.061 respectively). Also, there was no significant correlation between the solCD44 level in each patient and control group in serum (P value = 0.61) and in saliva (P value = 0.445).Conclusions:Determination of solCD44 level in saliva and serum can be a useful method for diagnosis the person’s involvement with cancer cells and the cancer in the early stages. But according to the controversial outcomes of past studies, larger and more accurate studies are needed in groups with more cases of oral cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Salivary and Serum Soluble CD44 Levels between Patients with Oral SCC and Healthy Controls

Seyedmajidi

Foroughi

et al. 2018

Asian Pac J Cancer Prev

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“…1 However, prognosis in OSCC depends on the histopathological grading and clinical staging of the tumour. 1,2,4,7 Rate of dysplasia may also show the following abnormal cell characteristics which include increase in mitotic figures, binucleation and multinucleation, changes in shape and size of nuclear, hyperchromatic, and keratinization. 7 Mild dysplasia, moderate dysplasia to severe dysplasia categories may show abnormalities epithelium with many different grades.…”

Section: Introductionmentioning

confidence: 99%

Immunoexpression of Ki-67 in determining prognosis of oral cavity squamous cell carcinoma

Kintawati

Pramesti

2019

Padjadjaran J Dent

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Introduction: Several researchers have been stated that the right prognosis of oral squamous cell carcinoma (OSCC) can be achieved through assessment of clinical tumour staging and histopathological tumour grading as well. The use of biomarker in histopathological grading is helpful to ensure the prognosis. The objective of this study was to determine the correlation between expression of Ki-67 and histopathological grading of OSCC. Methods: A retrospective study was conducted by assessing 20 cases of paraffin-embedded OSCC derived from the Department of Pathology Anatomy of Hasan Sadikin Hospital Bandung in 2013. The OSCC performed was staining by hematoxylin-eosin while antibodies Ki-67 was used in immunohistochemistry reaction to determine the relation of expression of Ki-67 with histopathologic grade of OSCC for predicting prognosis. Results: The result shows that distribution of Ki-67 expression varied from 20% to 80% in each case. The ki-67 intensity was also distributed from weak, moderate and strong. Conclusion: There is a significant correlation between Ki-67 immunoexpression and the histopathological grading of squamous cell carcinoma (p < 0.01); thus, Ki-67 can be used to predict prognosis.

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5-Aminolevulinic acid-mediated photodynamic therapy for oral cancers and precancers

Chen¹,

Yu²,

Lin³

et al. 2012

Journal of Dental Sciences

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Potential biomarkers for the cytologic diagnosis of oral squamous cell carcinoma

Cited by 5 publications

References 120 publications

Comparison of Salivary and Serum Soluble CD44 Levels between Patients with Oral SCC and Healthy Controls

Comparison of Salivary and Serum Soluble CD44 Levels between Patients with Oral SCC and Healthy Controls

Immunoexpression of Ki-67 in determining prognosis of oral cavity squamous cell carcinoma

5-Aminolevulinic acid-mediated photodynamic therapy for oral cancers and precancers

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