Potential biological efficacy of Pinus plant species against oxidative, inflammatory and microbial disorders

Sharma, Aditi; Goyal, Rohit; Sharma, Lalit Kumar

doi:10.1186/s12906-016-1011-6

Cited by 52 publications

(60 citation statements)

References 30 publications

(27 reference statements)

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“…The increase of percentage mortality of the treated Aedes aegypti larvae is supported by the presence of phytochemicals in the Pinus merkusii extracts which have insecticidal activities. The least percentage mortality was noted in the control group (0 ppm concentration) which is extremely lower compared to those in the experimental 10,11,19 It is further noted that the percentage mortality increased with increasing concentrations of the plant extracts. Moreover, the mortality of mosquito larvae was also increased in relation to the time of exposure.…”

Section: Discussionmentioning

confidence: 72%

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Bioinsecticide Effect of Pinus merkusii Tree Bark Extract on Aedes aegypti larvae

Setiawan¹,

Ngadino²,

Sudjarwo³

2017

JYP

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Objective: Aedes aegypti is the vector responsible for the transmission of dengue fever, and it is a cosmotropical species that proliferates in the water stagnant areas near the houses.Therefore, it is necessary to find new bioinsectiside which is expected to have larvacidal effects. The aims of this study are to evaluate extracts of Pinus merkusii tree bark for efficacy against Aedes aegypti larvae. Methods: This experiment using a completely randomized design with 8 treatment groups. Each group contained five times repetition using 20 third instar larvae of Aedes aegypti with concentrations of Pinus merkusii tree bark extract are 0, 10, 20, 40. 80, 160, 320, 640 ppm. Larval mortality was observed for 24 h and LC50 was analyzed using Probit analysis. Results: Ethanol extract of Pinus merkusii tree bark extract showed highest larval mortality against the larvae of Aedes aegypti with LC50 = 96.3 ppm; LC90 = 298.4 ppm after 12 h, and LC50 = 58.4 ppm; LC90 = 125.7 ppm after 24 h. Conclusion: These findings suggest that extracts from Pinus merkusii tree bark have larvacidal effect that can be exploited in development of new bioinsecticides. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Section: Discussionmentioning

confidence: 72%

“…It has been reported that pinus plant components like phenolics, flavonoids, tannins and other constituents can be used to treat oxidative, inflammatory and microbial. 11 The aim of this study was to evaluate the potential of Pinus merkusii tree bark extract against the larvae of Aedes aegypti through larvicidal bioassays.…”

Section: Introductionmentioning

confidence: 99%

Bioinsecticide Effect of Pinus merkusii Tree Bark Extract on Aedes aegypti larvae

Setiawan¹,

Ngadino²,

Sudjarwo³

2017

JYP

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“…The phytochemical analysis of alkaloids, flavonoids, phenolic content, saponin, protein, quinone, sterols, Cardic glycoside, Tannin, Terpenoid, and reducing compound was performed following the standard protocol [9]. Total phenolic content (TPC) estimation was measured using Folin Ciocalteu's methods using gallic acid as a standard [10].…”

Section: Phytochemical Analysis and Determination Of Total Phenolic Cmentioning

confidence: 99%

“…In Nepal, it inhibits in the altitude range from 1,200 to 2,100 m in height. It was reported to have several medicinal importances, such as intestinal antiseptic, antidyslipidemic, and spasmolytic [2]. The wood, resin, gum, oil, seeds, needle, and bark from P. roxburghii have been used for the treatment of several diseases in many parts of the world [3].…”

Section: Introductionmentioning

confidence: 99%

Chemical profiling and biological activity analysis of cone, bark and needle of Pinus roxburghii collected from Nepal

Thapa¹,

Upreti²,

Pandey³

2018

J Intercult Ethnopharmacol

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“…gerardiana nut oil has anti-bacterial, anti-fungal, anti-viral, anti-septic, antineuralgic, choleretic, diuretic, expectorant, hypertensive properties (Amr and ISSN: 2198-4093 www.bmrat.org Abeer, 2011;Lawlees, 1992). Simillarly, hydro-alcoholic extract showed antiinflammatory anti-bacterial and antioxidant properties (Sharma et al, 2016). Since oxidative stress contributes significantly in platelet activation (Bartimoccia et al, 2015) and also synthetic anti-inflammatory drugs like aspirin has antiplatelet activity (Roth and Majerus, 1975), the objectives of this study was to investigate the fibrinolytic activity and effect on platelet aggregation.…”

Section: Introductionmentioning

confidence: 98%

A preliminary investigation of in vitro anti-thrombotic and anti-platelet activity of Pinus Gerardiana

et al. 2017

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Introduction: Hemostasis is a process which preserves the stability of a closed and highpressure circulatory system after any vascular injury. Circulating platelets are recruited to the site of injury, where they develop a major component of the developing thrombus, blood clotting, started by tissue factor, concludes in the generation of thrombin and fibrin. Thrombosis is a serious event in the arterial diseases and a major cause in the development of myocardial infarction, stroke and venous thrombo-embolism which justify prominent morbidity and mortality rate. The knowledge of molecular and cellular mechanism of the formation of thrombus has developed considerably in the recent studies by using different in-vitro and in-vivo models of diseases. P. gerardiana nut oil has been reported to possess anti-bacterial, anti-fungal, anti-viral, anti-septic, antineuralgic, diuretic, expectorant, hypertensive properties. However, hardly, any data is available regarding effects of nut oil on platelet function. In this study, fibrinolytic activity and effect on platelet aggregation were investigated. Method: P. gerardiana nut oil was extracted by using n-Hexane and then concentrated by rotary evaporator. Antithrombotic and fibrinolytic activities were evaluated on blood clot formation. Effects on platelet aggregation of the oil were determined based on collagen or epinephrine induced platelet aggregation. Results: P. gerardiana caused blood clot lysis in-vitro. P. gerardiana nut oil inhibited collagen dependent platelet aggregation while accelerated the epinephrine dependent platelet aggregation. In vitro whole blood coagulation was also reduced. In vivo P. gerardiana nut oil has no significant effect on blood cell indices.

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Potential biological efficacy of Pinus plant species against oxidative, inflammatory and microbial disorders

Cited by 52 publications

References 30 publications

Bioinsecticide Effect of Pinus merkusii Tree Bark Extract on Aedes aegypti larvae

Bioinsecticide Effect of Pinus merkusii Tree Bark Extract on Aedes aegypti larvae

Chemical profiling and biological activity analysis of cone, bark and needle of Pinus roxburghii collected from Nepal

A preliminary investigation of in vitro anti-thrombotic and anti-platelet activity of Pinus Gerardiana

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