Potential Biological Activities of Magnoflorine: A Compound from Aristolochia debilis Sieb. et Zucc

Abstract

-Magnoflorine, an important compound in Aristolochia, was usually used as an anxiolytic chemical. In this study, the magnoflorine was isolated from Aristolochia and the biological activities such as antioxidant, α-tyrosinase inhibitory, anti-inflammatory, and anticancer activities were investigated. The magnoflorine showed significant antioxidant activity as a 2,2-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenger, 50 µg/mL of the magnoflorine scavenged about 70.8% of all the free radicals. And it was good at α-tyrosinase inhibiting, 100 µg/mL of the magnoflorine inhibited 36.5% of the tyrosinase. High dosage of magnoflorine inhibited the inflammation production nitric oxide (NO), and the magnoflorine protected the murine macrophage cells (RAW 264.7) from LPS-induced apoptosis. The cell viability of human colon cancer calls (HT-29) was around 100% when treated with different dose of magnoflorine, it's suggesting that magnoflorine had no anticancer effect.

Interactions of a medicinal climber Tinospora cordifolia with supportive interspecific plants trigger the modulation in its secondary metabolic profiles

“…N-methylcoclaurine inhibits the solute carrier organic anion transporter family member 1B1 and 1B3 38 . It has also been established that jatrorrhizine, oblongine, N-methylcoclaurine and magnoflorine are agonist of dopamine receptors 39,40 . Compounds that are monoamine depletors, could be useful to treat Parkinson or Huntington’s disease.…”

Profiling and Pharmacokinetic Studies of Alkaloids in Rats After Oral Administration of Zanthoxylum nitidum Decoction by UPLC-Q-TOF-MS/MS and HPLC-MS/MS

“…Magnoflorine has been reported for its diverse pharmacological properties, such as anti-inflammatory, anti-bacteria and immunomodulatory effects [36,37,38,39]. Some of these properties might contributed to anti-inflammation and analgesic effect of Z. nitidum decoction in clinic use.…”

In Vitro Free Radical Scavenging Activity of Aristolochia Tagala

“…Phenolic antioxidants have shown to have excellent antioxidant activity, while other groups of phytochemicals like terpenoids, alkaloids have shown to have moderate antioxidant activity [20]. The antioxidant activity exhibited by Fraction I of A. tagala was due to the present of compounds like magnoflorine which was reported to have antioxidant activity both in vitro and in vivo system and was also reported to have anti-inflammatory activity [22][23][24], apigenin dimethyl ether; reported to have potential antidiabetic and antiobesity properties [23,25], Aristolone, N-Trans-Feruloyldopamine previously reported to have antioxidant activity [26,27]. Aristolochia tagla have been reported to exhibit potential anticancer activity, anti-inflammatory activity, antimicrobial activity [15,[28][29][30].…”