Potential beneficial effect of some adipokines positively correlated with the adipose tissue content on the cardiovascular system

Sawicka, Magdalena; Janowska, Joanna; Chudek, Jerzy

doi:10.1016/j.ijcard.2016.07.054

Cited by 48 publications

(35 citation statements)

References 147 publications

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“…Finally, the greater increases observed in the Racil et al 35 study, which analyzed 12-week interval training of high-intensity exercise in 34 adolescent females, highlighting the benefits of high-intensity interval exercise interventions in obese population. 50 In sum evidence suggests that adipokines are strongly correlated with BF 51 and that adequate amounts of exercise reduce BF, 14 therefore it is possible that any associations found in such an analysis would be due to decreases in BF alone.…”

Section: Discussionmentioning

confidence: 99%

Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials

et al. 2016

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Background/Objective:Adipokines are involved in the etiology of diabetes, insulin resistance, and the development of atherosclerosis and other latent-onset complications. The objective of this meta-analysis was to determine the effectiveness of exercise interventions on adipokines in pediatric obesity.Subjects/Methods:A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of exercise interventions on adipokines (adiponectin, leptin, resistin and visfatin) in pediatric obesity (6–18 years old). Fourteen randomized controlled trials (347 youths) were included. Weighted mean difference (WMD) and 95% confidence intervals were calculated.Results:Exercise was associated with a significant increase in adiponectin (WMD=0.882 μg ml−1, 95% CI, 0.271–1.493) but did not alter leptin and resistin level. Likewise, exercise intensity and change in body fat; as well as total exercise program duration, duration of the sessions, and change in body fat all significantly influenced the effect of exercise on adiponectin and leptin, respectively.Conclusions:Exercise seems to increase adiponectin levels in childhood obesity. Our results also suggested that exercise on its own, without the concomitant presence of changes in body composition levels, does not affect leptin levels.

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Section: Discussionmentioning

confidence: 99%

Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials

et al. 2016

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“…Among the many diseases that contribute to the development of heart failure (HF), coronary artery disease (CAD) [1], hypertension (HT) [2], obesity [3], and tachyarrhythmias, especially atrial fibrillation (AF) [4,5], play a leading role. A link between obesity-related insulin resistance (IR) and HF has also been described [6], including: alteration in glucose and free fatty acid metabolism in cardiac myocytes, induction of inflammation and oxidative stress, and promotion of overactivity of the renin-angiotensin II system [7].…”

Section: Introductionmentioning

confidence: 99%

“…A link between obesity-related insulin resistance (IR) and HF has also been described [6], including: alteration in glucose and free fatty acid metabolism in cardiac myocytes, induction of inflammation and oxidative stress, and promotion of overactivity of the renin-angiotensin II system [7]. Moreover, HF is associated with low-grade chronic inflammation, sympathetic nervous system hyperactivity, and elevated circulating catecholamine levels [3,8].…”

Section: Introductionmentioning

confidence: 99%

Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure

et al. 2018

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Background/Aim: Elevated plasma concentration of retinol-binding protein 4 (RBP4) has recently emerged as a potential new risk factor for cardiovascular diseases, including hypertension (HT) and coronary artery disease (CAD). Limited data suggest that RBP4 promotes inflammatory damage to cardiomyocytes and participates in the development of heart failure (HF). This study aimed to analyze the relationship between concentrations of plasma RBP4 and serum N-terminal proBNP (NT-proBNP), a powerful biomarker of left ventricle dysfunction, in the older Polish population. Methods: The study sample consisted of 2,826 (1,487 men) participants of the PolSenior study, aged 65 years and older, including a subgroup hospitalized for HF (n = 282). In all subjects, plasma concentrations of RBP4, interleukin-6 (IL-6), serum level of NT-proBNP, and hs-CRP were measured. Additionally, BMI, estimated glomerular filtration rate (eGFR), and HOMA-IR were calculated. The prevalence of HT, CAD, atrial fibrillation (AF), and medication were considered as potential confounders. Results: Similar RBP4 levels were found in subjects with NT-proBNP < 125 and ≥125 ng/mL, with and without AF, and in the subgroups hospitalized for HF with and without AF. Regression analysis revealed no association between log₁₀(NT-proBNP) and log₁₀(RBP4). Plasma levels of RBP4 were increased by HT occurrence and diuretic therapy, while diminished with regard to female gender, age, eGFR values, AF, and IL-6 levels. Conclusion: Our results show that RBP4 is affected by GFR but cannot be considered as an independent biomarker of heart muscle dysfunction.

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“…The effects of adiponectin in the regulation of insulin sensitivity have been documented since 1996 (7,8). Recently, adiponectin has also been shown to play a role in the protection and inhibition of cardiovascular diseases (9,10). …”

Section: Introductionmentioning

confidence: 99%

Adiponectin inhibits oxidization-induced differentiation of T helper cells through inhibiting costimulatory CD40 and CD80

Xiao

Deng

Shang

et al. 2017

Braz J Med Biol Res

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Adiponectin is a multifunctional adipokine that has several oligomeric forms in the blood stream, which broadly regulates innate and acquired immunity. Therefore, in this study, we aimed to observe the differentiation of T helper (Th) cells and expression of costimulatory signaling molecules affected by adiponectin. The mRNA and protein expression levels of adiponectin and its receptors in oxidized low density lipoprotein cholesterol-treated endothelial cells were assayed by real time PCR and immunofluorescence. The endothelial cells were then treated with adiponectin with or without adipoR1 or adipoR2 siRNA and co-cultured with T lymphocytes. The distribution of Th1, Th2 and Th17 subsets were assayed by flow cytometry. The effects of adiponectin on costimulatory signaling molecules HLA-DR, CD80, CD86 and CD 40 was also assayed by flow cytometry. The results showed that endothelial cells expressed adiponectin and its receptor adipoR1 and adipoR2, but not T-cadherin. Adiponectin suppressed Th1 and Th17 differentiation through adipoR1 receptor, contributed to the inhibition of CD80 and CD40, and inhibited differentiation of Th1 and Th17 by inhibiting antigen presenting action.

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Potential beneficial effect of some adipokines positively correlated with the adipose tissue content on the cardiovascular system

Cited by 48 publications

References 147 publications

Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials

Exercise, adipokines and pediatric obesity: a meta-analysis of randomized controlled trials

Plasma Level of Retinol-Binding Protein 4, N-Terminal proBNP and Renal Function in Older Patients Hospitalized for Heart Failure

Adiponectin inhibits oxidization-induced differentiation of T helper cells through inhibiting costimulatory CD40 and CD80

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