Potential Applications of Carbomer in Oral Mucoadhesive Controlled Drug Delivery System: A Review

Singla, Anil Kumar; Chawla, Manish; Singh, Àmarjit

doi:10.1081/ddc-100101318

Cited by 168 publications

(98 citation statements)

References 79 publications

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“…Figure 3 shows that, at the same concentration of CP 974P (0.3% or 0.4%), viscosity of the complex solution is much higher than that of carbopol solution. It is known that viscosity of acid carbopol solution can increase when neutralized (Singla et al, 2000), so the increase in viscosity demonstrated carboxyl groups of carbopol have been partly or totally neutralized, which may have resulted from the interaction between carbopol and ATM.…”

Section: Rheological Studiesmentioning

confidence: 99%

New method for ophthalmic delivery of azithromycin by poloxamer/carbopol-based in situ gelling system

2010

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Section: Rheological Studiesmentioning

confidence: 99%

New method for ophthalmic delivery of azithromycin by poloxamer/carbopol-based in situ gelling system

2010

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“…Mucoadhesive nanoparticulate systems such as polymercoated liposomes were found to be useful carriers for improved oral delivery because of their prolonged retention in the GI tract and excellent penetration into the mucus layer 5 . The mucoadhesive liposomes can be prepared by coating drug carrier surface by various mucoadhesive polymers such as chitosan [10][11][12][13] , Carbopol 9,14,15 , and Eudragit…”

Section: Introductionmentioning

confidence: 99%

“…Its mucoadhesive properties are due to the molecular attractive forces formed by the electrostatic interaction between positively charged chitosan and negatively charged mucosal surfaces 17,18 . Carbopol polymers are polymers of acrylic acid cross-linked with polyalkenyl ethers or divinyl glycol and they are also finding numerous applications in oral mucoadhesive drug delivery because of their ability to interact with the mucus glycoprotein and to remain localized to a specific site 14,15,19 . Polymethacrylates for pharmaceutical purposes became known under the trademark Eudragit.…”

mentioning

confidence: 99%

Mucoadhesive liposomal delivery systems: the choice of coating material

Karn

Vanić

Pepić

et al. 2010

Drug Development and Industrial Pharmacy

121

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Objective: Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. Materials and methods: Liposomes containing model drug atenolol were prepared by the modified ethanol injection method. Liposomes containing atenolol were coated by different mucoadhesive polymers, for example, chitosan, Carbopol 974P, Eudragit L100, and Eudragit S100, to optimize the choice of coating material. The delivery systems were tested for their in vitro mucoadhesiveness. Results: Liposomes prepared by the ethanol injection method were of satisfactory size (around 100 nm, before coating). Through the coating of liposomes in the presence of unentrapped material, the entrapment efficiency for drug was increased. In vitro mucoadhesive test confirmed the mucoadhesive properties of the coated layer for all tested polymers; however, Eudragit S100-coated liposomes were superior to other coating materials. Discussion: Eudragit coating appeared to be an optimal polymer choice. These preliminary data indicate that polymer-coated mucoadhesive liposomes are able to carry sufficient amount of drug and to remain attached to the intestinal mucosa for a sufficient period of time to enable prolonged absorption of entrapped drug. Conclusion: While keeping in mind that the in vivo conditions may vary with the in vitro ones, we may recommend the system described in our work for possible oral delivery of peptides and phytochemicals.

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“…This work focuses on the development of an inexpensive vaginal gel formulation for the sustained delivery of PYD using GRAS (generally regarded as safe) ingredients-polyacrylic acid (PAA) and a cellulose derivative (15,27,34,38). In particular, hydroxylethyl cellulose (HEC) has been used in several vaginal gel formulations, including the universal placebo gel (32).…”

mentioning

confidence: 99%

Vaginal Microbicide Gel for Delivery of IQP-0528, a Pyrimidinedione Analog with a Dual Mechanism of Action against HIV-1

Mahalingam

Simmons

Ugaonkar

et al. 2011

Antimicrob Agents Chemother

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Pyrimidinediones, a novel class of compounds, have previously been shown to possess antiviral activity at nanomolar concentrations. One member of this class of compounds, IQP-0528, was selected as the lead molecule for formulation development owing to its stability at physiologically relevant conditions, wide therapeutic window, and antiviral activity in the nanomolar range. Here, we report the development of two vaginal gels-3.0% hydroxyethyl cellulose (HEC) formulation and a 0.65% Carbopol formulation-for the sustained delivery of IQP-0528. Stability studies under accelerated conditions confirmed the chemical stability of IQP-0528 and mechanical stability of the gel formulation for 3 months. In vitro release studies revealed that diffusion-controlled release of IQP-0528 occurred over 6 h, with an initial lag time of approximately 1 h. Based on the drug release profile, the 3.0% HEC gel was selected as the lead formulation for safety and activity evaluations. The in vitro and ex vivo safety evaluations showed no significant loss in cell viability or significant inflammatory response after treatment with a 3.0% HEC gel containing 0.25% IQP-0528. In an in vitro HIV-1 entry inhibition assay, the lead formulation showed an 50% effective concentration of 0.14 g/ml for gel in culture media, which corresponds to ϳ0.001 M IQP-0528. The antiviral activity was further confirmed by using polarized cervical explants, in which the formulation showed complete protection against HIV infection. In summary, these results are encouraging and warrant further evaluation of IQP-0528 gel formulations in in vivo models, as well as the development of alternative formulations for the delivery of IQP-0528 as a microbicide.

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Potential Applications of Carbomer in Oral Mucoadhesive Controlled Drug Delivery System: A Review

Cited by 168 publications

References 79 publications

New method for ophthalmic delivery of azithromycin by poloxamer/carbopol-based in situ gelling system

New method for ophthalmic delivery of azithromycin by poloxamer/carbopol-based in situ gelling system

Mucoadhesive liposomal delivery systems: the choice of coating material

Vaginal Microbicide Gel for Delivery of IQP-0528, a Pyrimidinedione Analog with a Dual Mechanism of Action against HIV-1

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