New method for ophthalmic delivery of azithromycin by poloxamer/carbopol-based in situ gelling system

Cao, Feng; Zhang, Xiaolin; Ping, Qineng

doi:10.3109/10717544.2010.483255

Cited by 43 publications

(28 citation statements)

References 29 publications

(32 reference statements)

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“…4); when poloxamer 407 concentration increases there was a significant reduction in gelation temperature (*p less than 0.05). This is consistent with many works [20][21][22][23]. Park et al found a linear relationship between P407 concentration and sol-gel transition temperature over a concentration range of 10-25%; the transition temperature is linearly reduced when P407 concentration has been increased [24].…”

Section: Fig 3: Phase Change or Solution-gel Transition At Differentsupporting

confidence: 92%

Ophthalmic in-Situ Sustained Gel of Ciprofloxacin, Preparation and Evaluation Study

Al-bazzaz

Alkotaji

2018

Int J App Pharm

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Objective: This work aims to formulate and evaluate an ophthalmic in-situ gel of ciprofloxacin hydrochloride (HCl) using poloxamer 407 (P407) as a gelling agent and hydroxypropyl methylcellulose (HPMC) as a viscosity modifier. The objective of this work was to prolong the contact time as the in-situ gel will be converted into a gel upon contact with the cul-de-sac. Methods: Ciprofloxacin HCl ophthalmic in-situ gel was prepared by utilizing (P407) as a temperature-dependent polymer while hydroxypropyl methylcellulose was used as a viscosity modifier. The system was evaluated for physical appearance, pH, drug content, sterility, irritancy and stability. In addition, gelation temperature and a viscosity at different shear rates and different temperatures were studied. The compatibility of the polymer with ciprofloxacin was studied by using fourier transform infrared spectroscopy (FTIR). The in vitro release of the drug was also evaluated and supported by a preliminary in vivo test.Results: The results showed that the prepared formulas were clear, with acceptable pH and the drug contents were within the acceptable limits. FTIR results detected no incompatibility between poloxamer 407 and ciprofloxacin HCl. Notably, the viscosity of the system showed a pseudoplastic behaviour where a reduction in viscosity upon increasing the shear rate was observed. The in vitro release study confirmed the prolongation of the release of the optimized formula (F6) up to 8 h. Upon application of F6 into eyes of rabbits there was no irritancy. In addition, in vivo elimination study showed a prolonged contact for the in-situ gel in comparison with the rapid clearance of eye drop. Stability study indicated the stability of the optimized formula (F6). Conclusion: The prepared optimized formula (F6) represents a successful, safe, stable and prolonged release in-situ gel formula of ciprofloxacin.

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Section: Fig 3: Phase Change or Solution-gel Transition At Differentsupporting

confidence: 92%

Ophthalmic in-Situ Sustained Gel of Ciprofloxacin, Preparation and Evaluation Study

Al-bazzaz

Alkotaji

2018

Int J App Pharm

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“…This hydrogel system showed good biodegradability, sustained release, and ocular biocompatibility, indicating that the system is a safe candidate for sustained ophthalmic drug delivery. Many other in situ polymeric gelling systems, such as chitosan, 80 poloxamer, 81 HPMC, 82 PEG-poly-e caprolactone (PCL)-PEG, 83 poly(N-isopropylacrylamide)/chitosan, 84 poloxamer/ chitosan, 85 pluronic F-127/chitosan, 86 and poloxamer/ carbopol 87 were explored for topical ocular applications.…”

Section: Pluronicsmentioning

confidence: 99%

Novel Strategies for Anterior Segment Ocular Drug Delivery

Cholkar

Patel

Vadlapudi

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

147

107

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Research advancements in pharmaceutical sciences have led to the development of new strategies in drug delivery to anterior segment. Designing a new delivery system that can efficiently target the diseased anterior ocular tissue, generate high drug levels, and maintain prolonged and effective concentrations with no or minimal side effects is the major focus of current research. Drug delivery by traditional method of administration via topical dosing is impeded by ocular static and dynamic barriers. Various products have been introduced into the market that prolong drug retention in the precorneal pocket and to improve bioavailability. However, there is a need of a delivery system that can provide controlled release to treat chronic ocular diseases with a reduced dosing frequency without causing any visual disturbances. This review provides an overview of anterior ocular barriers along with strategies to overcome these ocular barriers and deliver therapeutic agents to the affected anterior ocular tissue with a special emphasis on nanotechnology-based drug delivery approaches.

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“…The key issue of this strategy is to encapsulate the gel in its freely flowing form and trigger sol-gel transition when it is subjected to the physiological environment. Although gelation could be induced by a variety of stimuli like UV light, pH and ions (Gong et al, 2009a;Gupta et al, 2007;Kazakov et al, 2002;Patton and Palmer, 2005a;Gong et al, 2012), a mechanism of thermosensitive sol-gel transition was employed in this study, using a pharmaceutically acceptable polymer, poloxamer (PEO/PPO/PEO triblock copolymer), as in situ gel (Cao et al, 2010;Gong et al, 2009bGong et al, , 2013Lei et al, 2012;Ma et al, 2008;Patton and Palmer, 2005b;Wang et al, 2013). The aqueous poloxamer exhibits properties of macromolecular solution and turns to micellar gel when ambient temperature arises over the sol-gel transition temperature (T gel ).…”

Section: Introductionmentioning

confidence: 99%

Liposomes interiorly thickened with thermosensitive nanogels as novel drug delivery systems

Zhang

Chen

Lü

et al. 2013

International Journal of Pharmaceutics

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New method for ophthalmic delivery of azithromycin by poloxamer/carbopol-based in situ gelling system

Cited by 43 publications

References 29 publications

Ophthalmic in-Situ Sustained Gel of Ciprofloxacin, Preparation and Evaluation Study

Ophthalmic in-Situ Sustained Gel of Ciprofloxacin, Preparation and Evaluation Study

Novel Strategies for Anterior Segment Ocular Drug Delivery

Liposomes interiorly thickened with thermosensitive nanogels as novel drug delivery systems

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