Potential Application of Dendrimers in Drug Delivery: A Concise Review and Update

Parajapati, Sunil Kumar; Maurya, Sandip; Das, Manas; Tilak, Vijay Kumar; Verma, Krishna Kr; Dhakar, Ram Chand

doi:10.22270/jddt.v6i2.1195

Cited by 31 publications

(25 citation statements)

References 115 publications

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“…The results demonstrated that this nanosystem does not induce adverse host responses, including immune and/or inflammatory reactions after administration. This demonstrates that PAMAM dendrimers can be used successfully in conjugates with antigens [122,128].…”

Section: Dendrimers In Vaccinesmentioning

confidence: 80%

“…These nanocarriers have demonstrated promising properties in CNS drug delivery with low toxicity and low immunogenicity as well as increased solubility, stability, and permeability of drugs. Furthermore, dendrimers have more efficient paracellular and transcellular transport across the BBB, which makes them ideal carriers for targeting water-insoluble drugs to the brain [122]. Katare et al [123] investigated the efficiency of water-insoluble antipsychotic drug haloperidol via the intranasal route using the PAMAM dendrimer.…”

Section: Dendrimers In Central Nervous Systems (Cns) Drug Deliverymentioning

confidence: 99%

“…This complex would provide a high concentration of the drug in the nasal area. PAMAM dendrimers, for example, have caught the attention of researchers regarding nose-to-brain targeting [122]. Perez et al [125] studied intranasal delivery with dendrimers by coupling radioactive small interfering ribonucleic acid (siRNA) to PAMAM dendrimers to form dendriplexes (siRNA−dendrimer complexes) and formulated these particles into mucoadhesive gels.…”

Section: Dendrimers In Nasal Drug Deliverymentioning

confidence: 99%

“…Among the several commercially available dendrimers, PAMAM dendrimers have received the most attention as potential gene delivery agents due to their cationic nature which enables DNA binding at physiological pH by electrostatic interactions. Literature suggests that functionalized dendrimers are much less toxic than the native dendrimers [122]. Luo et al [126] revealed the low cytotoxicity of PEG-modified PAMAM dendrimers and their efficiency on the DNA delivery to the cells.…”

Section: Dendrimers In Gene Deliverymentioning

confidence: 99%

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Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

2019

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The European Medicines Agency (EMA) and the Current Good Manufacturing Practices (cGMP) in the United States of America, define excipient as the constituents of the pharmaceutical form other than the active ingredient, i.e., any component that is intended to furnish pharmacological activity. Although dendrimers do not have a pharmacopoeia monograph and, therefore, cannot be recognized as a pharmaceutical excipient, these nanostructures have received enormous attention from researchers. Due to their unique properties, like the nanoscale uniform size, a high degree of branching, polyvalency, aqueous solubility, internal cavities, and biocompatibility, dendrimers are ideal as active excipients, enhancing the solubility of poorly water-soluble drugs. The fact that the dendrimer’s properties are controllable during their synthesis render them promising agents for drug-delivery applications in several pharmaceutical formulations. Additionally, dendrimers can be used for reducing the drug toxicity and for the enhancement of the drug efficacy. This review aims to discuss the properties that turn dendrimers into pharmaceutical excipients and their potential applications in the pharmaceutical and biomedical fields.

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Section: Dendrimers In Vaccinesmentioning

confidence: 80%

Section: Dendrimers In Central Nervous Systems (Cns) Drug Deliverymentioning

confidence: 99%

Section: Dendrimers In Nasal Drug Deliverymentioning

confidence: 99%

Section: Dendrimers In Gene Deliverymentioning

confidence: 99%

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Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

2019

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“…The effervescent reaction among carbonate/bicarbonate salts, citric/tartic acid, CO2 is released in presence of water when the formulation is put in the beaker it will sink with a production of gas it rises up and floats. [20] (ii).Volatile liquid containing system…”

Section: )Effervescent Floating Drug Delivery Systemsmentioning

confidence: 99%

Current Approaches on Gastroretentive Drug Delivery systems

Pund

Shendge

Pote

2020

J. Drug Delivery Ther.

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Over recent years, there have been many efforts to develop the absorption rate of medications and the therapeutic efficacy of oral dosage types. GRDDS for strengthen the pharmacological effects of drugs with a small uptake site, are unbalanced at pH greater than 7, are dissolved under acidic region, and are effective local region in the stomach. The gastro retentive systems that have the different evaluation parameter that according to the dosage forms. There are many criteria for the choosing of the drug used in the gastro-retardant systems as the drug should be sparingly stable, it should be compatible with the gastric region, and narrow absorption. In this review, we have summarized the information related to the various approaches for enhancing and prolonging of the dosage forms in the stomach for their extended-release of action. Also talking about the many natural and synthetic polymers is used in the formulation with their different grade and their ratio that affects on the release action. The many scientist and inventors have increased their interest in developing the novel dosage forms and they staying in the stomach for showing the prolonged period action. We have also discussed the novel technology are involved in the gastric retention many companies has been developed the polymer grades for using it in the formulation for showing the retention action. Keywords: Introduction, Approaches, Novel technologies, Polymer used in floating systems.

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Pharmacological Evaluation of Novel Organoiron Dendrimers as Antimicrobial and Anti‐Inflammatory Agents

Abd‐El‐Aziz

Abdelghani

El-Ghezlani

et al. 2020

Macromolecular Bioscience

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The synthesis of a novel and attractive class of nonsteroidal anti‐inflammatory and antimicrobial organoiron dendrimers attached to the well‐known drug ibuprofen is achieved. The structures of these dendrimers are established by spectroscopic and analytical techniques. The antimicrobial activity of these dendrimers is investigated and tested against five human pathogenic Gram‐positive and Gram‐negative bacteria, and minimum inhibitory concentrations are reported. Some of these synthesized dendrimers exhibit higher inhibitory activity against methicillin‐resistant Staphylococcus aureus, vancomycin‐resistant Enterococcus faecium, and Staphylococcus warneri compare to the reference drugs. As well, the in vitro and in vivo anti‐inflammatory activities of these dendrimers are evaluated. The results of in vivo anti‐inflammatory activity and histopathology of inflamed paws show that all dendrimers display considerable anti‐inflammatory activity; however, second‐generation dendrimer (G2‐D6) shows the best anti‐inflammatory activity, which is more potent than the commercial drug ibuprofen at the same tested dose. Results of the toxicity study reveal that G2‐D6 is the safest drug on biological tissues.

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Potential Application of Dendrimers in Drug Delivery: A Concise Review and Update

Cited by 31 publications

References 115 publications

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

Current Approaches on Gastroretentive Drug Delivery systems

Pharmacological Evaluation of Novel Organoiron Dendrimers as Antimicrobial and Anti‐Inflammatory Agents

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