Over recent years, there have been many efforts to develop the absorption rate of medications and the therapeutic efficacy of oral dosage types. GRDDS for strengthen the pharmacological effects of drugs with a small uptake site, are unbalanced at pH greater than 7, are dissolved under acidic region, and are effective local region in the stomach. The gastro retentive systems that have the different evaluation parameter that according to the dosage forms. There are many criteria for the choosing of the drug used in the gastro-retardant systems as the drug should be sparingly stable, it should be compatible with the gastric region, and narrow absorption. In this review, we have summarized the information related to the various approaches for enhancing and prolonging of the dosage forms in the stomach for their extended-release of action. Also talking about the many natural and synthetic polymers is used in the formulation with their different grade and their ratio that affects on the release action. The many scientist and inventors have increased their interest in developing the novel dosage forms and they staying in the stomach for showing the prolonged period action. We have also discussed the novel technology are involved in the gastric retention many companies has been developed the polymer grades for using it in the formulation for showing the retention action.
Keywords: Introduction, Approaches, Novel technologies, Polymer used in floating systems.
The recent advances in the drug delivery system using a variety of technological platforms have resulted in innovation in the attitude towards diagnosis and therapeutics alike in the present times. Mesoporous Silica possesses favourable chemical properties, thermal stability, and biocompatibility. The unique structure of mesoporous silica makes possible the effective loading of drugs and their subsequent release in a controlled manner at the target site. The properties like pore size, high drug loading, and porosity as well as the surface properties of Mesoporous silica make them a suitable platform for many drug delivery applications. This review focuses on the applications and the advances made in the mesoporous silica to broaden the spectrum of its use especially in the field of medicine. The Mesoporous Silica carrier has proved its use in the field of biosensing, controlled and targeted drug release, gene delivery, water treatment, solubility and bioavailability enhancement and wound healing.
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