Potential Antioxidant and Antiviral Activities of Hydroethanolic Extracts of Selected Lamiaceae Species

Duque-Soto, Carmen; Borrás-Linares, Isabel; Quirantes-Piné, Rosa; Falcó, Irene; Sánchez, Glòria; Segura‐Carretero, Antonio; Lozano-Sánchez, Jesús

doi:10.3390/foods11131862

Cited by 12 publications

(13 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was reported that the antiviral mechanism is provided by the number of hydroxyl groups present in the benzene ring. 33–35 …”

Section: Discussionmentioning

confidence: 99%

“…It was reported that the antiviral mechanism is provided by the number of hydroxyl groups present in the benzene ring. [33][34][35] ADMET and Drug-Likeness Analysis Currently, computational studies are in the modeling stage of studying the drug's pharmacokinetics, including absorption, distribution, metabolism, excretion, and toxicity (ADMET). 36 Pharmacokinetics prediction of a compound needs to be seen using computational studies because this method is more cost-effective and more efficient.…”

mentioning

confidence: 99%

See 1 more Smart Citation

In silico Study of Antiviral Activity of Polyphenol Compounds from Ocimum basilicum by Molecular Docking, ADMET, and Drug-Likeness Analysis

Kurnia¹,

Putri²,

Tumilaar³

et al. 2023

AABC

View full text Add to dashboard Cite

The SARS-CoV-2 virus is a disease that has mild to severe effects on patients, which can even lead to death. One of the enzymes that act as DNA replication is the main protease, which becomes the main target in the inhibition of the SARS-CoV-2 virus. In finding effective drugs against this virus, Ocimum basilicum is a potential herbal plant because it has been tested to have high phytochemical content and bioactivity. Apigenin-7-glucuronide, dihydrokaempferol-3-glucoside, and aesculetin are polyphenolic compounds found in Ocimum basilicum. Purpose: The purpose of this study was to analyze the mechanism of inhibition of the three polyphenolic compounds in Ocimum basilicum against the main protease and to predict pharmacokinetic activity and the drug-likeness of a compound using the Lipinski Rule of Five. Patients and Methods: The method used is to predict the molecular docking inhibition mechanism using Autodock 4.0 tools and use pkcsm and protox online web server to analyze ADMET and Drug-likeness. Results:The binding affinity for apigenin-7-glucuronide was −8.77 Kcal/mol, dihydrokaempferol-3-glucoside was −8.96 Kcal/mol, and aesculetin was −5.79 Kcal/mol. Then, the inhibition constant values were 375.81 nM, 270.09 nM, and 57.11 µM, respectively. Apigenin-7-glucuronide and dihydrokaempferol-3-glucoside bind to the main protease enzymes on the active sites of CYS145 and HIS41, while aesculetin only binds to the active sites of CYS145. On ADMET analysis, these three compounds met the predicted pharmacokinetic parameters, although there are some specific parameters that must be considered especially for aesculetin compounds. Meanwhile, on drug-likeness analysis, apigenin-7-glucuronide and dihydrokaempferol-3-glucoside compounds have one violation and aesculetin have no violation. Conclusion: Based on the data obtained, Apigenin-7-glucuronide and dihydrokaempferol-3-glucoside are compounds that have more potential to have an antiviral effect on the main protease enzyme than aesculetin. Based on pharmacokinetic parameters and druglikeness, three compounds can be used as lead compounds for further research.

show abstract

“…It was reported that the antiviral mechanism is provided by the number of hydroxyl groups present in the benzene ring. 33–35 …”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

In silico Study of Antiviral Activity of Polyphenol Compounds from Ocimum basilicum by Molecular Docking, ADMET, and Drug-Likeness Analysis

Kurnia¹,

Putri²,

Tumilaar³

et al. 2023

AABC

View full text Add to dashboard Cite

show abstract

“…In a study conducted in Spain, the effect of ethanolic-aqueous extract of plant species belonging to different genera on FCV was investigated. Among the species used, it has been reported that plant species Origanum [91]. In this context, it is seen that the plants are effective against FCV.…”

Section: Feline Calicivirus (Fcv) (Genus: Vesivirus)mentioning

confidence: 98%

A Review on Antiviral Plants Effective Against Different Virus Types

Mohammed¹,

Uysal²,

Sevindik³

2023

pps

View full text Add to dashboard Cite

The treatment of microbial infections has proven challenging for humans in recent years. Synthetic medications, such as antimicrobial agents, are used for treating these infections. Antimicrobials derived from natural sources have gained popularity as an alternative to manufactured medications due to their lack of adverse effects. Plants, which play a significant role in this setting, have historically served as a reliable natural defence against several pathogens. In this study, studies on plants used against viral diseases are mentioned. Studies on viruses that cause disease have been compiled in the literature. According to the findings, it has been reported in the literature that many different plant species are effective against herpes simplex virus (HSV-1, HSV-2), human immunodeficiency virus (HIV), influenza virus (A, B) and parainfluenza, Poliovirus, Astrovirus, Parvovirus, Sindbis virus (SINV), Feline calicivirus (FCV), Rhinovirus, Echovirus, Rotavirus, Bovine alphaherpesvirus 1 (BoHV-1), Reovirus, Vaccinia virus (VACV), Cardiovirus A (Encephalomyocarditis virus; EMCV), Coxsackie virus, Semliki forest, Measles virus, Newcastle disease virus (NDV), Coronavirus, Adenovirus (ADV-3, ADV-5, ADV-8, ADV -11), Canine distemper virus (CDV), Lumpy skin disease virus (LSDV), Hepatitis A, B, C virus and Enterovirus. To combat viruses, plants can be considered a potentially invaluable natural resource.

show abstract

“…Although polyphenols were isolated from various plant parts [ 166 ], they are found at higher levels in the outer layers of tissues [ 167 ] as the production of these metabolites can be induced by both biotic and abiotic factors such as reactive oxygen and nitrogen species, insufficient amounts of nutrients, low temperatures, UV light, predators, parasites, pathogens, wounding, and other stress conditions [ 163 , 168 , 169 ]. Nevertheless, the antimicrobial potential of polyphenols has not been fully deciphered [ 170 ] due to the complexity of their natural mixtures in plants [ 171 ] and their inconsistent activity [ 172 ].…”

Section: Aromatic Plants As Biocontrol Agentsmentioning

confidence: 99%

Biocontrol Activity of Aromatic and Medicinal Plants and Their Bioactive Components against Soil-Borne Pathogens

Greff

Sáhó

Lakatos

et al. 2023

Plants

View full text Add to dashboard Cite

Soil-borne phytopathogens can have detrimental effects on both cereal and horticultural crops resulting in serious losses worldwide. Due to their high efficiency and easy applicability, synthetic pesticides are still the primary choice in modern plant disease control systems, but stringent regulations and increasing environmental concerns make the search for sustainable alternatives more pressing than ever. In addition to the incorporation of botanicals into agricultural practices, the diversification of cropping systems with aromatic and medicinal plants is also an effective tool to control plant diseases through providing nutrients and shaping soil microbial communities. However, these techniques are not universally accepted and may negatively affect soil fertility if their application is not thoroughly controlled. Because the biocontrol potential of aromatic and medicinal plants has been extensively examined over the past decades, the present study aims to overview the recent literature concerning the biopesticide effect of secondary metabolites derived from aromatic and medicinal plants on important soil-borne plant pathogens including bacteria, fungi, and nematodes. Most of the investigated herbs belong to the family of Lamiaceae (e.g., Origanum spp., Salvia spp., Thymus spp., Mentha spp., etc.) and have been associated with potent antimicrobial activity, primarily due to their chemical constituents. The most frequently tested organisms include fungi, such as Rhizoctonia spp., Fusarium spp., and Phytophthora spp., which may be highly persistent in soil. Despite the intense research efforts dedicated to the development of plant-based pesticides, only a few species of aromatic herbs are utilized for the production of commercial formulations due to inconsistent efficiency, lack of field verification, costs, and prolonged authorization requirements. However, recycling the wastes from aromatic and medicinal plant-utilizing industries may offer an economically feasible way to improve soil health and reduce environmental burdens at the same time. Overall, this review provides comprehensive knowledge on the efficiency of aromatic herb-based plant protection techniques, and it also highlights the importance of exploiting the residues generated by aromatic plant-utilizing sectors as part of agro-industrial processes.

show abstract

Potential Antioxidant and Antiviral Activities of Hydroethanolic Extracts of Selected Lamiaceae Species

Cited by 12 publications

References 49 publications

In silico Study of Antiviral Activity of Polyphenol Compounds from Ocimum basilicum by Molecular Docking, ADMET, and Drug-Likeness Analysis

In silico Study of Antiviral Activity of Polyphenol Compounds from Ocimum basilicum by Molecular Docking, ADMET, and Drug-Likeness Analysis

A Review on Antiviral Plants Effective Against Different Virus Types

Biocontrol Activity of Aromatic and Medicinal Plants and Their Bioactive Components against Soil-Borne Pathogens

Contact Info

Product

Resources

About