Potential Antioxidant and Antidiabetic Activities of Kayu Kuning (Arcangelisia Flava)

Wahyudi, Lilik Duwi; Ratnadewi, Anak Agung Istri; Siswoyo, Tri Agus

doi:10.1016/j.aaspro.2016.02.155

Cited by 14 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The NRPS gene analysis shows that all amplified NRPS fragments were closely related to the Bacillus NRPS gene with various similarities ( Table 4 ). Previous research has showed that Bacillus subtilis and Bacillus flexus with antimicrobial activity against Vibrio species were also harboring PKS and NRPS genes [ 22 ]. Polyketide synthase (PKS) and nonribosomal peptide synthetase are the enzymes with multidomains which are responsible for bioactive compound production in many microorganisms, specifically bacteria, actinobacteria, and fungi.…”

Section: Resultsmentioning

confidence: 99%

Potential Antimicrobe Producer of Endophytic Bacteria from Yellow Root Plant (Arcangelisia flava (L.)) Originated from Enggano Island

Sipriyadi

Masrukhin

Wibowo

et al. 2022

International Journal of Microbiology

View full text Add to dashboard Cite

Exploration studies of endophytic bacteria from Arcangelisia flava (L.) and their potential have not much been conducted. This research aims to explore and characterize the antimicrobial activity of endophytic bacteria in A. flava against pathogenic bacteria. This research consists of several steps including the isolation of bacteria, screening of the antimicrobial activity assay using the dual cross streak method, molecular identification through 16s rDNA analysis, and characterization of bioactive compound production through PKS-NRPS gene detection and GC-MS analysis. There are 29 endophytic bacteria that were successfully isolated from A. flava. The antimicrobial activity showed that there are four potential isolates AKEBG21, AKEBG23, AKEBG25, and AKEBG28 that can inhibit the growth of pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The 16S rDNA sequence analysis showed that these isolates are identified as Bacillus cereus. These four isolates are identified as able to produce the bioactive compounds through the detection of polyketide synthase (PKS) and nonribosomal peptide synthase (NRPS)-encoding genes. B. cereus AKEBG23 has the highest inhibition against pathogenic bacteria, and according to the GC-MS analysis, five major compounds are allegedly involved in its antimicrobial activity such as butylated hydroxytoluene (BHT), diisooctyl phthalate, E-15-heptadecenal, 1-heneicosanol, and E-14-hexadecenal. This result suggested that B. cereus AKEBG23 as the endophytic bacterium from A. flava has a beneficial role as well as the plant itself. The bacterium produces several bioactive compounds that are allegedly involved in its antimicrobial activity against pathogenic bacteria.

show abstract

Section: Resultsmentioning

confidence: 99%

Potential Antimicrobe Producer of Endophytic Bacteria from Yellow Root Plant (Arcangelisia flava (L.)) Originated from Enggano Island

Sipriyadi

Masrukhin

Wibowo

et al. 2022

International Journal of Microbiology

View full text Add to dashboard Cite

show abstract

“…CO refers to the absorbance values of the control sample measured at the beginning of the incubation. To determine the concentration of EO that offers 50% antioxidant activity (EC 50 ), the researchers plotted the antioxidant percentage against the varying concentrations of the oil …”

Section: Methodsmentioning

confidence: 99%

Analysis of Primary and Secondary Metabolites, Physical Properties, Antioxidant and Antidiabetic Activities, and Chemical Composition of Rosmarinus officinalis Essential Oils under Differential Water Stress Conditions

Laftouhi,

Mahraz,

Hmamou

et al. 2024

ACS Omega

View full text Add to dashboard Cite

This study investigated the effects of varying water stress levels on Rosmarinus officinalis essential oils (EO). Three samples (S1, S2, and S3) were cultivated under different stress levels (40, 60, and 80%). Increased water stress led to changes in primary and secondary metabolites, EO contents, and physical properties. Antioxidant activity varied, with S2 exhibiting the highest IC 50 value. In terms of antidiabetic activity, S2 showed robust α-amylase inhibition, while S3 displayed a commendable influence. For α-galactosidase inhibition, S3 had a moderate effect, and S2 stood out with increased efficacy. Gas chromatography− mass spectrometry analysis revealed stress-induced changes in major compounds. The study enhances the understanding of plant responses to water stress, with potential applications in antioxidant therapy and diabetes management. The findings emphasize the importance of sustainable water management for optimizing the EO quality in its various uses.

show abstract

“…Stenocephol and DAB (3,3'-diaminobenzidine), were subjected to in vitro anti-diabetic activity using glycogen as the substrate and rabbit muscle glycogen phosphorylase as an enzyme. DAB (3,3'-Diaminobenzidine) was used as a reference drug (Ponnusamy et al 2011;Wahyudi et al 2016). To perform an anti-diabetic activity, stock solutions of the selected compounds having a concentration of 200 mM (0.022 g) were prepared.…”

Section: Glycogen Phosphorylase Inhibitionmentioning

confidence: 99%

Characterization of stenocephol from Seriphidium stenocephalum as potent HepG2 cell growth and glycogen phosphorylase inhibitor

Shafiq

Arshad

Brogi

et al. 2022

Natural Product Research

View full text Add to dashboard Cite

Plant-derived compounds represent an important source for developing innovative drugs. One of the widely distributed plants, especially in Afghanistan and Pakistan, Seriphidium stenocephalum, was investigated in this study to identify bioactive compounds. The plant extract was subjected to silica gel column chromatography, four phenolic acid derivatives were isolated, while stenocephol was obtained by ethyl acetate fraction. Stenocephol was subjected to experimental screening for anti-diabetic and

show abstract

Potential Antioxidant and Antidiabetic Activities of Kayu Kuning (Arcangelisia Flava)

Cited by 14 publications

References 9 publications

Potential Antimicrobe Producer of Endophytic Bacteria from Yellow Root Plant (Arcangelisia flava (L.)) Originated from Enggano Island

Potential Antimicrobe Producer of Endophytic Bacteria from Yellow Root Plant (Arcangelisia flava (L.)) Originated from Enggano Island

Analysis of Primary and Secondary Metabolites, Physical Properties, Antioxidant and Antidiabetic Activities, and Chemical Composition of Rosmarinus officinalis Essential Oils under Differential Water Stress Conditions

Characterization of stenocephol from Seriphidium stenocephalum as potent HepG2 cell growth and glycogen phosphorylase inhibitor

Contact Info

Product

Resources

About