Potential Anticancer Agents VIII.

Abstract

aqueous alcoholic extract of the root An investigation of the constituents responsible for the antitumor activity observed for extracts of Baliospermum montanum roots has afforded five new phorbol ester derivatives exhibiting anticancer activity. Of these, montanin ( I ) was found to be closely related to huratoxin (6), and baliospennin (3) to mancinellin (14). Evidence for the structures of the other isolates, 12-deoxyphorbol 13-palmitate (2), 12-deoxy-5p-hy-dro-xyphorbol13-myristate (4) and 12-deoxy-16-hydroxyphorbol13-palmitate(5), was obtained by correlation with known compounds and preparation of derivatives.of Baliospermum montanum (WILD.)MUELL.-ARG. (Euphorbiaceae) exhibited activity against the P-388 lymphocytic leukemia in vivo [2]. Since no previous biological or phytochemical results had been reported previously for a member of the genus Baliospermum, we were interested in determining the nature of the constituents responsible for the observed anticancer activity. It is interesting to note that extracts of B. montanum have been used in India for many years in the treatment of cancerous states [3]. Results and DiscussionA sample of B. montanum roots was

Daphnane-Type Diterpene Orthoesters and their Biological Activities

“…(Thymelaeaceae) as a weak irritant to the mouse ear [26]. From Baliospermum montanum [34] as well as from Cunuria spruceana [35], Gnidia kraussiana [36] and Diarthron vericulosum [29], montanin (38) revealed to have antileukaemia, anticancer and piscicidal activities. As a 5-deoxy isomer of simplexin, daphnopsis factor R4 (16) was found in the roots of Daphnopsis racemosa and demonstrated weaker irritancy than simplexin [37].…”

Effect of Baliospermum montanum nanomedicine apoptosis induction and anti-migration of prostate cancer cells

“…Its root is proclaimed to contain axillarenic acid, baliospermin, and montanin which is responsible for all the wide range of activities [15]. Five phorbol esters (montanin, baliospermin, 12-deoxyphorbol-13-palmitate, 12-deoxy-5b-hydroxyphorbol-13-myristate, and 12-deoxy-16-hydroxy phorbol-13-palmitate) were isolated from B. montanum roots and was reported for their antitumor activity [11]. Preliminary phytochemical analysis of B. montanum revealed the presence of compounds such as glycosides, flavonoids, tannins and triterpenoids in aqueous and alcohol extracts of the plant [12].…”

“…The various parts of the plant such as the roots, leaves, and seeds are used traditionally for the treatment of different ailments. The roots of B. montanum are ascribed to possess anticancer [11], antimicrobial [12], immunomodulatory Prostate cancer has been diagnosed as the second most frequent and the sixth among the cancer causing deaths among men worldwide. There is a limited scope for the prevalent therapies as prostate cancer advances and they present adverse aftermaths that have put way for us to delve into naturally available anticancer agents.…”

“…In vitro cytotoxic activity against HT-29 cell line at different concentrations was evaluated and the IC50 value calculated was below 50 mg/mL, indicating the potentiality of Baliospermum montanum Muell Arg extracts [18]. An aqueous alcoholic extract of the root of B. montanum exhibited an activity against the P-388 lymphocytic leukemia in vivo [11].…”

Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs

“…Jacaronone and derivatives Concentrations [1]:0.055mM, [5]:0.033mM, [6]: 0.039mM, [7]:0.033mM These distinct types of cell death and their effect on immune response prompted a hypothesis where physiological cell death or apoptosis was considered as intrinsically tolerogenic, whereas pathological cell death or necrosis was considered inherently immunogenic, consequently producing inflammatory response [21]. The response of immune system has been considered as transcendental for the elimination of tumor cells after treatment with chemotherapeutic agents [22].…”