Potent bioactive compounds from the ocean: some interesting aspects and applications

Abstract

over seventy percent of the earth's surface is covered by oceans, and it is an established fact now, that life originated in the oceans. additionally, the oceans are also the source of matchless natural products that are mainly accumulated in living organisms. several bioactive compounds of therapeutic interest have been isolated from marine invertebrates, and some of them have been reported to be of microbial origin. Numerous of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immuno-deficiency syndrome, etc., while others have also been shown to possess several valuable properties. the secondary metabolites of microorganisms, algae and invertebrates, possess lifesaving properties, and are deadly toxins as well, depending on the dosage. the useful applications of these compounds, as bio-markers is also being explored, to further enrich pharmacological information. recent developments have opened colossal areas of research for the isolation of biologically active compounds from marine flora and fauna.

Effects of seaweeds extract on growth, survival, antibacterial activities, and immune responses of Penaeus monodon against Vibrio parahaemolyticus

“…Seaweeds are potentially excellent sources of highly bioactive secondary metabolites such as sterols, hormones, vitamins, and bio-membrane structural components that can help to develop new, functional aquaculture ingredients (Lavanya and Veerappan 2011;Esquer-Miranda et al 2016). Some of these compounds have been considered for their anticarcinogenic, antibacterial, and anti-inflammatory properties (Pandey 2012). Many researchers have concentrated on testing seaweeds and other natural products by providing new bioactive agents to improve shrimp defense systems (Redo et al 1989;Silver and Bostian 1993;Immanuel et al 2004;Valgas et al 2007;Esquer-Miranda et al 2016;AftabUddin et al 2017;Dashtiannasab and Yeganeh 2017).…”

Inhibitory Effect on Biofilm Formation of Pathogenic Bacteria Induced by Rubrolide Lactam Analogues

“…Marine organisms produce a great variety of natural metabolites with a range of pharmacological properties. 10,11 Among such structurally diverse metabolites, a group of γ-alkylidenebutenolides known as rubrolides (1, Figure 1) have shown the ability to inhibit the growth of Gram-positive bacteria and are now being considered as promising models for the development of novel antibacterial drugs. 12−15 As examples, rubrolides A, B, and C, isolated from Ritterella rubra, were capable of inhibiting S. aureus and Bacillus subtilis growth with an MIC ranging from 2 to 11 μg/disc.…”

“…In this context, the use of natural compounds with described antimicrobial activities as models for the discovery and development of novel therapeutic agents has become a major research strategy. , Compounds, which show antimicrobial activity, can be used as tools for finding new resistant pathways and modes of action. Marine organisms produce a great variety of natural metabolites with a range of pharmacological properties. , Among such structurally diverse metabolites, a group of γ-alkylidenebutenolides known as rubrolides ( 1 , Figure ) have shown the ability to inhibit the growth of Gram-positive bacteria and are now being considered as promising models for the development of novel antibacterial drugs. − …”

Advances in Anticancer Drug Research from Marine Organisms: An Overview

“…These cytotoxic compounds help them prey, & also save their lives & defend themselves, when attacked by a stronger predator. [2][3][4][5] The fact that these organisms produce & store such cytotoxic chemicals, as secondary metabolites, make them favourite & lucrative destinations for scientific investigation, targetted towards Anticancer Drug discovery. Research in exploring bioactive secondary metabolites, from the ocean has yielded several promising compounds, & as much as, even some QSAR studies have also been attempted on these cytotoxic compounds.…”