Potent Antibacterial Nanoparticles against Biofilm and Intracellular Bacteria

Mu, Haibo; Tang, Jiang‐Jiang; Liu, Qianjin; Sun, Chunli; Wang, Tingting; Duan, Jinyou

doi:10.1038/srep18877

Cited by 217 publications

(135 citation statements)

References 32 publications

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“…Mu et al [43] used gold nanoparticles loaded with gentamicin to treat biofilms. Other studies have treated E. coli biofilms with essential oil capsules stabilized by nanoparticles [44] or by loading the nanoparticles with Eucalyptus globulus oil [45].…”

Section: Discussionmentioning

confidence: 99%

Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms

Chan

Cadena

Townley

et al. 2017

J. R. Soc. Interface.

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Nanoparticulate delivery of biocides has the potential to decrease levels of exposure to non-target organisms, and miminize long-term exposure that can promote the development of resistance. Silica nanoparticles are an ideal vehicle since they are inert, biocompatible, biodegradable, and thermally and chemically stable. Encapsulation of biocides within nanoparticulates can improve their stability and longevity and maximize the biocidal potential of hydrophobic volatile compounds. Herein, we have shown that the plant secondary metabolites allyl isothiocyanate and cinnamaldehyde demonstrated increased antimicrobial activity against Escherichia coli in planktonic form, when packaged into mesoporous silica nanoparticles. Furthermore, the biocide-loaded nanoparticles showed activity against Pseudomonas aeruginosa biofilms that have inherent resistance to antimicrobial agents. The delivery platform can also be expanded to traditional biocides and other non-conventional antimicrobial agents.

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Section: Discussionmentioning

confidence: 99%

Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms

Chan

Cadena

Townley

et al. 2017

J. R. Soc. Interface.

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“…Various modified NPs with antibiofilm activity such as gold NPs loaded with gentamycin [60], silver NPs surface treated with Allophylus cobbe extract [61], and copper oxide NPs [62] were reported. The effect of MNPs on preformed biofilm was previously described for OA-MNPs; however, its ability to inhibit new biofilm formation was not investigated [35].…”

Section: Mnps ( G/ml)mentioning

confidence: 99%

Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles

Shebl

Farouk

Azzazy

2017

Journal of Nanomaterials

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Unmodified magnetic nanoparticles (MNPs) lack antibacterial potential. We investigated MNPs surface modifications that can impart antibacterial activity. Six MNPs species were prepared and characterized. Their antibacterial and antibiofilm potentials, surface affinity, and cytotoxicity were evaluated. Prepared MNPs were functionalized with citric acid, amine group, amino-propyl trimethoxy silane (APTMS), arginine, or oleic acid (OA) to give hydrophilic and hydrophobic MNPs with surface charge ranging from −30 to +30 mV. Prepared MNPs were spherical in shape with an average size of 6-15 nm. Hydrophobic (OA-MNPs) and positively charged MNPs (APTMS-MNPs) had significant concentration dependent antibacterial effect. OA-MNPs showed higher inhibitory potential against S. aureus and E. coli (80%) than APTMS-MNPs (70%). Both particles exhibited surface affinity to S. aureus and E. coli. Different concentrations of OA-MNPs decreased S. aureus and E. coli biofilm formation by 50-90%, while APTMS-MNPs reduced it by 30-90%, respectively. Up to 90% of preformed biofilms of S. aureus and E. coli were destroyed by OAMNPs and APTMS-MNPs. In conclusion, surface positivity and hydrophobicity enhance antibacterial and antibiofilm properties of MNPs.

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“…Anti-biofilm activities of phosphatidylcholine-decorated Au NPs loaded with gentamycin have been reported against P. aeruginosa, S. aureus as well as intracellular Listeria monocytogenes and E. coli. 143 NP-based drug delivery could subjugate systemic toxic effects of antibiotics, decrease uptake and increase efflux of drugs, biofilm formation and intracellular bacterial infection.…”

mentioning

confidence: 99%

Nanomaterials for alternative antibacterial therapy

Hemeg

2017

IJN

433

262

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Despite an array of cogent antibiotics, bacterial infections, notably those produced by nosocomial pathogens, still remain a leading factor of morbidity and mortality around the globe. They target the severely ill, hospitalized and immunocompromised patients with incapacitated immune system, who are prone to infections. The choice of antimicrobial therapy is largely empirical and not devoid of toxicity, hypersensitivity, teratogenicity and/or mutagenicity. The emergence of multidrug-resistant bacteria further intensifies the clinical predicament as it directly impacts public health due to diminished potency of current antibiotics. In addition, there is an escalating concern with respect to biofilm-associated infections that are refractory to the presently available antimicrobial armory, leaving almost no therapeutic option. Hence, there is a dire need to develop alternate antibacterial agents. The past decade has witnessed a substantial upsurge in the global use of nanomedicines as innovative tools for combating the high rates of antimicrobial resistance. Antibacterial activity of metal and metal oxide nanoparticles (NPs) has been extensively reported. The microbes are eliminated either by microbicidal effects of the NPs, such as release of free metal ions culminating in cell membrane damage, DNA interactions or free radical generation, or by microbiostatic effects coupled with killing potentiated by the host’s immune system. This review encompasses the magnitude of multidrug resistance in nosocomial infections, bacterial evasion of the host immune system, mechanisms used by bacteria to develop drug resistance and the use of nanomaterials based on metals to overcome these challenges. The diverse annihilative effects of conventional and biogenic metal NPs for antibacterial activity are also discussed. The use of polymer-based nanomaterials and nanocomposites, alone or functionalized with ligands, antibodies or antibiotics, as alternative antimicrobial agents for treating severe bacterial infections is also discussed. Combinatorial therapy with metallic NPs, as adjunct to the existing antibiotics, may aid to restrain the mounting menace of bacterial resistance and nosocomial threat.

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Potent Antibacterial Nanoparticles against Biofilm and Intracellular Bacteria

Cited by 217 publications

References 32 publications

Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms

Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms

Effect of Surface Charge and Hydrophobicity Modulation on the Antibacterial and Antibiofilm Potential of Magnetic Iron Nanoparticles

Nanomaterials for alternative antibacterial therapy

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