Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms

Chan, Andrea; Cadena, Marimar Bravo; Townley, Helen E.; Fricker, Mark D.; Thompson, Ian P.

doi:10.1098/rsif.2016.0650

Cited by 28 publications

(20 citation statements)

References 41 publications

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“…However, encapsulating or loading essential oils into nanoparticles is still a big challenge. In most of the process that was reported, large amounts of organic solvents or surfactants were used, and the drug loads were unsatisfactory (<10 wt%) [11,14,15]. Thus, nanoparticles in some film nanocomposite containing essential oil only played the role of improving the film mechanical properties, but not as a drug carrier [16].…”

Section: Introductionmentioning

confidence: 99%

Zein/MCM-41 Nanocomposite Film Incorporated with Cinnamon Essential Oil Loaded by Modified Supercritical CO2 Impregnation for Long-Term Antibacterial Packaging

et al. 2020

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Antimicrobial medicine and food packages based on bio-based film containing essential oils have attracted great attention worldwide. However, the controlled release of essential oils from these film nanocomposites is still a big challenge. In this study, a long-term antibacterial film nanocomposite composed of zein film and cinnamon essential oil (CEO) loaded MCM-41 silica nanoparticles was prepared. The CEO was loaded into MCM-41 particles via modified supercritical impregnation efficiently with a high drug load (>40 wt%). The morphologies of the prepared nanoparticles and film nanocomposite were characterized by a scanning electron microscope. The release behaviors of CEO under different temperatures, high humidity, continuous illumination and in phosphate buffer solution (PBS) solution were investigated. The results showed that the film nanocomposite had an outstanding release-control effect. The addition of MCM-41 nanoparticles also improved the mechanical properties of zein films. The antibacterial effect of CEO was significantly prolonged by the film nanocomposite; indicating the CEO film nanocomposite fabricated via modified supercritical CO2 impregnation was a potential long-term antibacterial medicine or food package material.

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Section: Introductionmentioning

confidence: 99%

Zein/MCM-41 Nanocomposite Film Incorporated with Cinnamon Essential Oil Loaded by Modified Supercritical CO2 Impregnation for Long-Term Antibacterial Packaging

et al. 2020

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“…Nanoparticles are a promising tool in the field of biomedicine, providing novel approaches for delivering agents in a targeted manner for therapeutic, imaging and diagnostic purposes [ 1 – 7 ]. For example, nano-sized polymer or mesoporous capsules can be synthesized and loaded with a therapeutic agent [ 5 , 7 , 8 ]. Ideally, the physico-chemical properties of the capsule allow for preferential interaction with a specific type of cell [ 5 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

An analytical approach for quantifying the influence of nanoparticle polydispersity on cellular delivered dose

Johnston

Faria

Crampin

2018

J. R. Soc. Interface.

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Nanoparticles provide a promising approach for the targeted delivery of therapeutic, diagnostic and imaging agents in the body. However, it is not yet fully understood how the physico-chemical properties of the nanoparticles influence cellular association and uptake. Cellular association experiments are routinely performed in an effort to determine how nanoparticle properties impact the rate of nanoparticle–cell association. To compare experiments in a meaningful manner, the association data must be normalized by the amount of nanoparticles that arrive at the cells, a measure referred to as the delivered dose. The delivered dose is calculated from a model of nanoparticle transport through fluid. A standard assumption is that all nanoparticles within the population are monodisperse, namely the nanoparticles have the same physico-chemical properties. We present a semi-analytic solution to a modified model of nanoparticle transport that allows for the nanoparticle population to be polydisperse. This solution allows us to efficiently analyse the influence of polydispersity on the delivered dose. Combining characterization data obtained from a range of commonly used nanoparticles and our model, we find that the delivered dose changes by more than a factor of 2 if realistic amounts of polydispersity are considered.

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“…Thompson and co‐workers developed effective delivery of allyl isothiocyanate (AIT) and cinnamaldehyde (CNAD) by using MS NPs for treating biofilms . The release of both AIT and CNAD from MS showed a high initial rate over the first hour due to the steep concentration gradient established from within and outside the pores in the external solution or due to release of compounds adsorbed on the external surface of the NPs.…”

Section: Ms In Antibacterial Applicationsmentioning

confidence: 99%

Mesoporous Silica‐Based Materials with Bactericidal Properties

Bernardos

Piacenza

Sancenón

et al. 2019

Small

137

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Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM‐based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS‐loaded with antimicrobial agents, gated MS‐loaded with antimicrobial agents, MS with metal‐based nanoparticles, and MS‐loaded with metal ions) is provided.

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Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms

Cited by 28 publications

References 41 publications

Zein/MCM-41 Nanocomposite Film Incorporated with Cinnamon Essential Oil Loaded by Modified Supercritical CO2 Impregnation for Long-Term Antibacterial Packaging

Zein/MCM-41 Nanocomposite Film Incorporated with Cinnamon Essential Oil Loaded by Modified Supercritical CO2 Impregnation for Long-Term Antibacterial Packaging

An analytical approach for quantifying the influence of nanoparticle polydispersity on cellular delivered dose

Mesoporous Silica‐Based Materials with Bactericidal Properties

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