Mesoporous Silica‐Based Materials with Bactericidal Properties

Abstract

Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM‐based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS‐loaded with antimicrobial agents, gated MS‐loaded with antimicrobial agents, MS with metal‐based nanoparticles, and MS‐loaded with metal ions) is provided.

Formulation of Mesoporous Silica Nanoparticles for Controlled Release of Antimicrobials for Stone Preventive Conservation

“…Other interesting features of MSNs are their inert and biodegradable nature (Barbé et al, 2004;Lu et al, 2007;Trewyn et al, 2008;Lin and Haynes, 2009). As far as the drug delivery issue is concerned, MSNs are considered very promising because of their capacity in loading larger amounts of drugs as compared to conventional mesoporous materials (Du et al, 2013;Ma et al, 2013;Niu et al, 2014;Lu et al, 2015;Bernardos et al, 2019).…”

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

“…MSNs with tunable particle size, pore volume, and morphology are promising carriers for drug delivery. The antibacterial agents inside the porous matrix are effectively shielded against enzymatic degradation (Bernardos et al, 2019). The surface chemistry of MSNs can be modified to facilitate the passage through biomembranes.…”

Advances in Active Packaging: Perspectives in Packaging of Meat and Dairy Products

“…Besides silver being used in meat packaging there are also metal oxides, such as titanium dioxide (TiO2), tungsten trioxide (WO3), and zinc oxide (ZnO) that can be used for the same purpose [18]. Mainly TiO2 nanoparticles have been used or better said implemented into polypropylene or a mix of petroxolin octadecanoic acid and OOP [67,68]. Also, on the subject of nanoclay as a way of packaging montomorillonite or MMT for short is a relatively affordable and broad material that is comprised of aluminum hydroxide between silica layers [69].…”