Potency of Xanthone Derivatives as antibacterial agent against Methicillin-Resistant Staphylococcus Aureus (MRSA)

Miladiyah, Isnatin; Rachmawaty, Farida Juliantina

doi:10.20885/jkki.vol8.iss2.art8

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Xanthones and xanthone derivatives can serve as antibacterial and antioxidants by disrupting bacterial cell membranes. It induces the release of lipoteichoic acid (LTA) from the cell wall of Gram-positive bacteria, which are covalently bonded to the outside of peptidoglycan that is used in bacterial cell division and osmotic defense [40] while stilbene compounds exert its antibacterial activity by interfering with the membrane stability and permeability of the bacterial cells [41]. At the same time, it is important to mention that there is a new emerging area of research where bacterial chaperones have been used as a novel antimicrobial target and development of novel anti microbials.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Endemic Artocarpus nobilis Thw Found in Sri Lanka

Senadeera

Fernando

Wickramasekara

et al. 2021

SAJRM

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Aims: To evaluate antibacterial activity of aqueous, methanol, dichloromethane, and hexane extracts of Artocarpus nobilis Thw. leaves and stem bark against Escherichia coli and Staphylococcus aureus using agar well diffusion method. Methodology: Matured fully expanded leaves and stem bark parts of Artocarpus nobilis were collected, air-dried, and grounded. The extraction was obtained using a decoction extraction method. Antibacterial activity was performed against Staphylococcus aureus (ATCC® 25923TM) and Escherichia coli (ATCC® 25922TM) using agar well diffusion method and gentamicin was used as a positive control. The whole experiment was done in triplicates and the diameter of the inhibition zone (in mm) was measured and recorded. Results: Results showed that aqueous bark extract (EC50 4.286 mg/mL) showed the highest efficacy and potency against E. coli while methanol bark extract (EC50 4.427 mg/mL) showed the highest efficacy and potency against S. aureus. R² and P values for aqueous, methanol, dichloromethane, and hexane extracts indicated that there was a strong, statistically significant correlation (P ≤ 0.05) between concentration and zone of inhibition for all extracts of A. nobilis against E. coli and S. aureus. Conclusion: This study showed that aqueous and methanol bark extracts of Artocarpus nobilis have marked in vitro dose-dependent antibacterial activity against E. coli and S. aureus respectively. Further studies are necessary to ascertain the mechanism and the active constituents responsible for the antibacterial activity of the of plant parts of Artocarpus nobilis.

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Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Endemic Artocarpus nobilis Thw Found in Sri Lanka

Senadeera

Fernando

Wickramasekara

et al. 2021

SAJRM

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“…However, bulky groups at the C-1 position may decrease the antibacterial activity [ 111 ]. In methicillin-resistant S. aureus strains, xanthones with hydroxyls at positions C-6, C-5, and C7, prenyl groups at C-4 and C-7, and dimethyl chromene rings at C-2 and C-3 present efficient activity [ 112 ]. Furthermore, Yan et al [ 113 ], in a study evaluating xanthones with various substituents at the C-1, C-3, and C-6 positions, found that an acetyl substituent group at the C-1 position showed membrane selectivity against S. aureus , a higher inhibition of biofilm formation, and better antibacterial activity in vivo when compared to other xanthones [ 113 ].…”

Section: Xanthonesmentioning

confidence: 99%

Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil

Kauffmann

Castro

2023

Antibiotics

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Phenolic compounds are natural substances that are produced through the secondary metabolism of plants, fungi, and bacteria, in addition to being produced by chemical synthesis. These compounds have anti-inflammatory, antioxidant, and antimicrobial properties, among others. In this way, Brazil represents one of the most promising countries regarding phenolic compounds since it has a heterogeneous flora, with the presence of six distinct biomes (Cerrado, Amazon, Atlantic Forest, Caatinga, Pantanal, and Pampa). Recently, several studies have pointed to an era of antimicrobial resistance due to the unrestricted and large-scale use of antibiotics, which led to the emergence of some survival mechanisms of bacteria to these compounds. Therefore, the use of natural substances with antimicrobial action can help combat these resistant pathogens and represent a natural alternative that may be useful in animal nutrition for direct application in food and can be used in human nutrition to promote health. Therefore, this study aimed to (i) evaluate the phenolic compounds with antimicrobial properties isolated from plants present in Brazil, (ii) discuss the compounds across different classes (flavonoids, xanthones, coumarins, phenolic acids, and others), and (iii) address the structure–activity relationship of phenolic compounds that lead to antimicrobial action.

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Comparison between the efficacy plant and synthetic origin dental products in the treatment of chronic catarrhal gingivitis.

et al. 2020

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Aim. Comparative clinical study of hygienic dental product of plant origin based -mangostin [1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one], a xanthone from mangosteen fruit, having antimicrobial and anti-inflammatory activity in the treatment of chronic generalized catarrhal gingivitis. Methods. The study included 319 patients aged 22 to 45 years. All patients were divided into two groups: the control group 20 people (males 40%, females 60%), average age 34.88.00 years; the comparison group 20 people (males 45%, females 55%), average age 35.07.10 year; the main group 20 people (males 40%, females 60%), average age 34.97.86 years. There were no statistically significant differences between all groups (p 0.05). The nosological form of the disease in the studied patients is chronic generalized catarrhal gingivitis (K05.1). Treatment in all groups was carried out using the standard regimen of complex therapy of chronic generalized catarrhal gingivitis. Therapy of the main group patients was supplemented by the use of the hygienic gel containing 1% -mangostin [1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one], whereas treatment of the comparison group patients was supplemented by the complex preparation containing 1% metronidazole and 0.25% chlorhexidine digluconate. The dental examination included a questionnaire with the registration of subjective data (patient complaints) and objective data on the state of the tissues of the mouth (index score) before and after therapy, as well as the dynamics of the indicators fixing during the entire treatment. Results. The performing a comparative study of the treatment effectiveness of chronic generalized catarrhal gingivitis, using a dental hygienic gel containing 1% -mangostin [1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one] as a part of complex therapy in comparison with the standard complex treatment regimen supplemented by dental product containing 1% metronidazole and 0.25% chlorhexidine digluconate, showed a marked improvement in subjective quality of life of patients. Pain during individual oral hygiene and food intake (decrease to 0%, p1 0.05, p2 0.05), a feeling of bursting in the gum (decrease to 0%, p1 0.05, p2 0.05), bad breath (decrease to 0%, p1 0.05, p2 0.05) and bleeding gums (decrease to 0%, p1 0.05, p2 0.05) were completely eliminated. Compared to the control group, OHI-S index of the main group decreased by 79% (from 1.9 to 0.4, p1 0.001, p2 0.001), PI index decreased by 80.6% (from 3.1 to 0.6, p1 0.001, p2 0.001) and SBI index decreased by 100% (from 3 to 0, p1 0.001, p2 0.001). During the course of treatment of patients with chronic generalized catarrhal gingivitis, a decrease in the average values of the PMA index was observed. In the group of patients using hygienic gel as a supplement to treatment, the decrease in this index was 85% (from 651.53 to 100.82%; p1 0.001, p2 0.05), and when using a complex drug containing 1% metronidazole and 0.25% chlorhexidine digluconate, the value of the PMA index decreased by 51% (from 611.17 to 301.4%; p1 0.001), in the control group, the index value decreased by 28% (from 671.67 to 481.26%; p1 0.001). Conclusion. In assessing of the subjective quality of life and index indicators of the periodontal status in the treatment of chronic generalized catarrhal gingivitis, the best results were observed in the group using a dental hygiene gel based on -mangostin [1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one], a xanthone from mangosteen fruit, compared with the control group and the group using a complex drug (1% metronidazole and 0.25% chlorhexidine digluconate).

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Potency of Xanthone Derivatives as antibacterial agent against Methicillin-Resistant Staphylococcus Aureus (MRSA)

Cited by 4 publications

References 35 publications

Antibacterial Activity of Endemic Artocarpus nobilis Thw Found in Sri Lanka

Antibacterial Activity of Endemic Artocarpus nobilis Thw Found in Sri Lanka

Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil

Comparison between the efficacy plant and synthetic origin dental products in the treatment of chronic catarrhal gingivitis.

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