Posztkondicionálás kísérletes alkalmazása aortakirekesztés kapcsánr

Szíjártó, Attila; Gyurkovics, Endre; Arányi, Péter; Ónody, Péter; Stangl, Rita; Tátrai, Miklós; Lotz, Gábor; Mihály, Zsuzsanna; Hegedüs, V; Blázovics, Anna; Kempler, Péter

doi:10.1556/maseb.62.2009.4.2

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…The most common ischemic/reperfusion injury in surgery are vascular clamps for vascular surgery as well as Tourniquets, used for orthopedic surgery of the limbs. Reperfusion of the acutely ischemic limb may cause significant local tissue damage and release of toxic metabolites [2] that initiate a cascade of events that may result in single or multiple organ dysfunction [3, 4]. …”

Section: Introductionmentioning

confidence: 99%

Lipid emulsion mitigates impaired pulmonary function induced by limb ischemia/reperfusion in rats through attenuation of local cellular injury and the subsequent systemic inflammatory

Xia

Chen

et al. 2017

BMC Anesthesiol

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BackgroundLimb ischemia/reperfusion causes inflammation and elicits oxidative stress that may lead to local tissue damage and remote organ such as lung injury. This study investigates pulmonary function after limb ischemia/reperfusion and the protective effect of a lipid emulsion (Intralipid).MethodsTwenty-four rats were divided into three groups: sham operation group (group S), ischemia/reperfusion group (group IR), and lipid emulsion treatment group (group LE). limb ischemia/reperfusion was induced through occlusion of the infrarenal abdominal aorta for 3 h. The microvascular clamp was removed carefully and reperfusion was provided for 3 h.ResultsThe mean arterial pressure in group LE was higher than group IR during the reperfusion period (P = 0.024). The heart rate of both group LE and IR are significantly higher than group S during the ischemia period(P < 0.001, P < 0.001, respectively). The arterial oxygen pressure of group LE was significantly higher than group IR (P = 0.003), the arterial carbon dioxide pressure of group LE were lower than that of group IR (P = 0.005). The concentration of plasma interleukin-6, tumor necrosis factor-α and malondialdehyde in group LE were significantly lower than group IR (P < 0.001, P = 0.009 and 0.029, respectively). The plasma superoxide dismutase activity in group LE was significantly higher than group IR (P = 0.029). The myeloperoxidase activity in lung tissues of group LE was significantly less than group IR (P = 0.046). Both muscle and lung in group IR were damaged seriously, whereas lipid emulsion (Intralipid) effectively reversed the damage. In summary, Intralipid administration resulted in several beneficial effects as compared to group IR, such as the pulmonary gas exchange and inflammatory.ConclusionsThe ischemic/reperfusion injury of limb muscles with resultant inflammatory damage to lung tissue can be mitigated by administration of a lipid emulsion (Intralipid, 20%, 5 ml/kg). The mechanisms attenuating such a physiological may be attributed to reduction of the degree of limb injury through a decrease in the release of local inflammatory mediators, a reduction of lipid peroxidation, and a blunting of the subsequent remote inflammatory response.

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Section: Introductionmentioning

confidence: 99%

Lipid emulsion mitigates impaired pulmonary function induced by limb ischemia/reperfusion in rats through attenuation of local cellular injury and the subsequent systemic inflammatory

Xia

Chen

et al. 2017

BMC Anesthesiol

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show abstract

“…Szijártó et al [ 13 ] also demonstrated IPC protection when IPC was performed on the lower limbs of rats, with three hours of ischemia and four hours of reperfusion. Santos et al [ 6 ] also performed mesenteric IR in rats, but used 30 minutes of ischemia and 60 minutes of reperfusion, causing intestinal lesions but not pulmonary lesions, thus demonstrating that these animals did not present significant damage to the lungs with these reduced periods of intestinal IR.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ischemic Postconditioning and Atorvastatin in the Prevention of Remote Lung Reperfusion Injury

Santos¹,

Dourado²,

Silva³

et al. 2018

Braz J Cardiovasc Surg

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ObjectiveThe aim of the present study was to evaluate the ability of ischemic postconditioning, atorvastatin and both associated to prevent or minimize reperfusion injury in the lung of rats subjected to ischemia and reperfusion by abdominal aortic clamping.MethodsWe used 41 Wistar norvegic rats, which were distributed into 5 groups: ischemia and reperfusion (I/R), ischemic postcondictioning (IPC), postconditioning + atorvastatin (IPC+A), atorvastatin (A) and SHAM. It was performed a medium laparotomy, dissection and isolation of the infra-renal abdominal aorta; except for the SHAM group, all the others were submitted to the aortic clamping for 70 minutes (ischemia) and posterior clamp removal (reperfusion, 70 minutes). In the IPC and IPC+A groups, postconditioning was performed between the ischemia and reperfusion phases by four cycles of reperfusion and ischemia lasting 30 seconds each. In the IPC+A and A groups, preceding the surgical procedure, administration of 3.4 mg/day of atorvastatin was performed for seven days by gavage. After the surgical procedure, the right caudal lobe was removed from the lung for histological study, using tissue injury score ranging from grade 1 (normal tissue) to grade 4 (intense lesion).ResultsThe mean lung injury was 3.6 in the I/R group, 1.6 in the IPC group, 1.2 in the IPC+A group, 1.2 in the A group, and 1 in the SHAM group (P<0.01).ConclusionIschemic postconditioning and atorvastatin were able to minimize lung reperfusion injury, alone or in combination.

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“…The supposed molecular mechanism of tissue protection of ischemic postconditioning involved the inhibition of opening of mitochondrial permeability transition pores (mPTP) [ 15 ]. Previous studies also demonstrated that postconditioning could decrease systemic inflammatory response (TNF- α ) and cause a marked reduction in reperfusion-related organ dysfunctions (lungs and kidneys) in a model of partial ischemia using infrarenal aortic clamping [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits

Jin

Kan

et al. 2017

BioMed Research International

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The authors aim to investigate protective effects of fasciotomy against ischemia reperfusion injury of skeletal muscle in rabbit and to compare the treatment effects of prereperfusion + fasciotomy and fasciotomy + postreperfusion against ischemia reperfusion injury of skeletal muscle. 24 healthy male Japanese white rabbits were randomly divided into 3 groups, and 4 hours' ischemia was established in these rabbits through surgery. Six hours' reperfusion was performed in group A; reperfusion + postfasciotomy was performed in group B; and prefasciotomy + reperfusion was performed in group C. Result showed that prefasciotomy and postfasciotomy could protect skeletal muscle against ischemia reperfusion injury, reduced MDA (malondialdehyde) expression, MPO (myeloperoxidase) expression, and apoptosis of muscle in the reperfused areas, increased Bcl-2 expression, and decreased Bax expression. The MDA and MPO levels in group B and group C were significantly lower than those in group A, and MDA and MPO levels in group C were significantly lower than those in group B. Prefasciotomy and postfasciotomy could protect against ischemia reperfusion injury in skeletal muscle. The protective effects of prefasciotomy against ischemia reperfusion injury are better than postfasciotomy.

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Posztkondicionálás kísérletes alkalmazása aortakirekesztés kapcsánr

Abstract: Postconditioning proves to be capable in conferring protection against different organ injuries caused by longer circulatory occlusions during elective major vascular surgeries.

Cited by 8 publications

References 19 publications

Lipid emulsion mitigates impaired pulmonary function induced by limb ischemia/reperfusion in rats through attenuation of local cellular injury and the subsequent systemic inflammatory

Lipid emulsion mitigates impaired pulmonary function induced by limb ischemia/reperfusion in rats through attenuation of local cellular injury and the subsequent systemic inflammatory

Effect of Ischemic Postconditioning and Atorvastatin in the Prevention of Remote Lung Reperfusion Injury

The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits

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