Postprandial profiles of CCK after high fat and high carbohydrate meals and the relationship to satiety in humans

Abstract

, D-L., Hellström, P M. et al. (2015) Postprandial profiles of CCK after high fat and high carbohydrate meals and the relationship to satiety in humans. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Participants and Design:Sixteen overweight/obese adults (11female/5male) participated in a randomised-crossover study (46years,29.8kg/m 2 ) in a university research centre. Plasma was collected preprandially and for 180min postprandially. Simultaneously, ratings of hunger/fullness were tracked for 180min before an ad libitum lunch was provided.Results: CCK8/33(s) levels increased more rapidly and reached a higher peak following HF =0.201,p=0.844). CCK8/33(s) profiles were not associated with subjective appetite during early and late phases of satiety; nor was there an association between CCK8/33(s) and meal size.Conclusions: These results demonstrate CCK levels were higher after HF meal compared to HCHO isocaloric meal. There was no association between CCK levels and intensity of satiety, or with meal size. Under these circumstances, CCK does not appear to play a unique independent role in satiety/satiation. CCK probably acts in conjunction with other peptides and the action of the stomach.

Gastrointestinal distribution of chicken gastrin-cholecystokinin family transcript expression and response to short-term nutritive state

“…CCK is heavily implicated in the short-term satiety response in vertebrate species ( Havel, 2001 , Murashita et al, 2007 , Moran, 2009 , Gibbons et al, 2016 , Honda et al, 2017 , Volkoff et al, 2017 ). The circulating peptide longevity is known to be very short ( Liddle et al, 1985 ), although a delay in transcriptional response might have been expected, as observed for the satiety factor peptide YY in chickens ( Reid et al, 2017 ).…”

Non-responders After Gastric Bypass Surgery for Morbid Obesity: Peptide Hormones and Glucose Homeostasis

“…A protease inhibitor cocktail was prepared, as described in earlier studies [17][18][19], consisting of 5.5 μL 10 mM KR-6 2 4 3 6 [ 2 0 ] ( D P P 4 i n h i b i t o r ) i n D M S O a n d a SIGMAFAST® protease inhibitor tablet [21] (both produced by Sigma-Aldrich Corp., St. Louis, MO, USA, cat no. K4264 and S8830) dissolved in 2100 μL of distilled water (50× stock).…”

Acute Effects of Dietary Carbohydrate Restriction on Glycemia, Lipemia and Appetite Regulating Hormones in Normal-Weight to Obese Subjects

“…Furthermore, the increase in GLP-1 secretion may, in part, explain the maintained β-cell glucose sensitivity despite the reduced glucose excursion after CRHP diet ingestion. The CCK response was increased 180 and 240 min after ingestion of the CRHP compared with HC breakfast due to increased fat content [ 65 ] in the CRHP (40E%) compared with HC (30E%) diet and coincided with the increase in satiety scores at these time points. Interestingly, we found, in our previous study, that CCK was increased to a larger extent by a CRHP compared with HC diet in subjects with T2DM concurrently with increased satiety.…”