Postoperative irradiation in the prevention of keloids

The effect of external electron beam on neointima in rat carotid artery injury model

“…ANOVA was used to examine the effect of external radiation doses and unpaired t test was used to compare the effects between the low radiation dose group (5-10 Gy) and high radiation dose group (15)(16)(17)(18)(19)(20).…”

“…It is well known that radiation can inhibit mesenchymal proliferation in the cases of keloid, hypertrophic scar, and heterotrophic bone formation (15)(16)(17)(18)(19)(20)(21), and Friedman et al (22)(23) suggested that it could be used for managing atheromatous plaque. Recently, some researchers have tried radiation for the prevention of restenosis following angioplasty.…”

Optimization of treatment and prevention of scars

“…Многие авторы докладывали об успешном более чем в 80% наблюдений иссечении келоидных рубцов с после-дующим облучением послеоперационной раны [81,92]. При этом частота развития рецидива снижалась до 10% [64,74].…”

<b>Irradiation and Postangioplasty Restenosis</b>

“…Histopathological evidence as revealed by autopsy studies shows the responses of human coronary arteries to angioplasty are a form of vessel wall stretch and dissection injury with subsequent scarring in the form of a proliferative neointima rich in extracellular matrix, similar to scars in other tissues. [12][13][14][15][16] This safe and effective use of radiation therapy for benign proliferative conditions has led a number of investigators to test whether local irra-diation might affect restenosis. This review is focused on the potential clinical application of endovascular brachytherapy for restenosis prevention.…”