Postoperative intermittent fasting prevents hippocampal oxidative stress and memory deficits in a rat model of chronic cerebral hypoperfusion

Hu, Yuan; Zhang, Miao; Chen, Yunyun; Yang, Ying; Zhang, Junjian

doi:10.1007/s00394-018-1606-4

Cited by 50 publications

(28 citation statements)

References 25 publications

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“…Nutrients 2020, 12, 1029; doi:10.3390/nu12041029 www.mdpi.com/journal/nutrients a reduction in blood pressure and heart rate [16][17][18][19][20]; a reduction in inflammation; and protection against neurodegeneration [17][18][19][21][22][23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats

et al. 2020

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Fasting is known to cause physiological changes in the endocrine pancreas, including decreased insulin secretion and increased reactive oxygen species (ROS) production. However, there is no consensus about the long-term effects of intermittent fasting (IF), which can involve up to 24 hours of fasting interspersed with normal feeding days. In the present study, we analyzed the effects of alternate-day IF for 12 weeks in a developing and healthy organism. Female 30-day-old Wistar rats were randomly divided into two groups: control, with free access to standard rodent chow; and IF, subjected to 24-hour fasts intercalated with 24-hours of free access to the same chow. Alternate-day IF decreased weight gain and food intake. Surprisingly, IF also elevated plasma insulin concentrations, both at baseline and after glucose administration collected during oGTT. After 12 weeks of dietary intervention, pancreatic islets displayed increased ROS production and apoptosis. Despite their lower body weight, IF animals had increased fat reserves and decreased muscle mass. Taken together, these findings suggest that alternate-day IF promote β -cell dysfunction, especially in developing animals. More long-term research is necessary to define the best IF protocol to reduce side effects.

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Section: Introductionmentioning

confidence: 99%

Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats

et al. 2020

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“…However, in the same study 30–40% CR increased GSH level in rats liver tissue compared to the AL‐fed groups . Similarly, effects of intermittent fasting on increasing GSH level in hippocampus tissue of 18‐week‐old male rats subjected to 24‐hour food deprivation every other day for 7 weeks were also reported . Moreover, compared to AL group, increased GSH level in liver tissue was reported in 8‐week‐old male rats following every other day fasting for 4 weeks.…”

Section: Discussionmentioning

confidence: 69%

“…For example, when eight‐week‐old male rats were fed every other day (alternative day fasting) for 1 month, lower MDA level was measured compared to controls in heart tissue of fasting group while no difference was reported in brain, muscle, and liver tissues . In another study, lower level of MDA was also measured in hippocampus of 18‐week‐old male rats that were deprived of food for 24 hr every other day for 7 weeks . Moreover, in human studies, a 54.3% decrease in serum MDA levels was measured in people who fasted from sunrise to sunset during Ramadan for 1 month.…”

Section: Discussionmentioning

confidence: 97%

Effects of long‐term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model

et al. 2019

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“…Furthermore, Arumugam et al (2010) showed that IF increased the HO-1 level in vulnerable brain regions, and the increased HO-1 level was correlated with decreasing infarct volume and neurological deficit following focal cerebral ischemic stroke in mice ( 26 ). Recently, Hu et al (2017) reported that postoperative IF for a week after chronic cerebral hypoperfusion in rats significantly decreased malondialdehyde (MDA) activity, maintained glutathione, SOD1, and SOD2 levels in the hippocampus, and improved memory deficit induced by the hypoperfusion ( 30 ). In our present study, we found that SOD2 and CAT immunoreactivities were hardly shown in CA pyramidal cells in the IF+Ischemia group; instead, the immunoreactivities were increased in non-pyramidal cells, which were found to be astrocytes ( 31 , 32 ), compared to the Ischemia group.…”

Section: Discussionmentioning

confidence: 99%

Intermittent fasting increases SOD2 and catalase immunoreactivities in the hippocampus but does not protect from neuronal death following transient ischemia in gerbils

Ahn

Noh²,

Shin³

et al. 2018

Mol Med Report

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Intermittent fasting has been shown to have neuroprotective effects against transient focal cerebral ischemic insults. However, the effects of intermittent fasting on transient global ischemic insult has not been studied much yet. The present study examined effects of intermittent fasting on endogenous antioxidant enzyme expression levels in the hippocampus and investigated whether the fasting protects neurons 5 days after 5 min of transient global cerebral ischemia. Gerbils were randomly subjected to either ad libitum or alternate-day intermittent fasting for two months and assigned to sham surgery or transient ischemia. Changes of antioxidant enzymes were examined using immunohistochemistry for cytoplasmic superoxide dismutase 1 (SOD1), mitochondrial (SOD2), catalase (CAT), and glutathione peroxidase (GPX). The effects of intermittent fasting on ischemia-induced antioxidant changes, neuronal damage/degeneration and glial activation were examined. The weight of fasting gerbils was not different from that of control gerbils. In controls, SOD1 and GPX immunoreactivities were strong in pyramidal neurons of filed cornu ammonis 1 (CA1). Transient ischemia in controls significantly decreased expressions of SOD1 and GPX in CA1 pyramidal neurons. Intermittent fasting resulted in increased expressions of SOD2 and CAT, not of SOD1 and GPX, in CA1 pyramidal neurons. Nevertheless, CA1 pyramidal neurons were not protected in gerbils subjected to fasting after transient ischemia, and inhibition of glial-cell activation was not observed in the gerbils. In summary, intermittent fasting for two months increased SOD2 and CAT immunoreactivities in hippocampal CA1 pyramidal neurons. However, fasting did not protect the CA1 pyramidal neurons from transient cerebral ischemia. The results of the present study indicate that intermittent fasting may increase certain antioxidants, but not protect neurons from transient global ischemic insult.

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Postoperative intermittent fasting prevents hippocampal oxidative stress and memory deficits in a rat model of chronic cerebral hypoperfusion

Abstract: Our results suggest that postoperative IF suppresses neuroinflammation and oxidative stress induced by chronic cerebral ischemia, thereby preserving cognitive function in a vascular dementia rat model.

Cited by 50 publications

References 25 publications

Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats

Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats

Effects of long‐term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model

Intermittent fasting increases SOD2 and catalase immunoreactivities in the hippocampus but does not protect from neuronal death following transient ischemia in gerbils

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