Postoperative cognitive disorder

Lyashenko, E A; Ivanova, L G; Чимагомедова, А Ш

doi:10.17116/jnevro202012010239

Cited by 8 publications

(2 citation statements)

References 50 publications

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“…Perioperative Neurocognitive Disorders (PND), the most common postoperative complication, lack effective treatment strategies. Approximately 40% of elderly patients display cognitive impairment or confusion postoperatively, leading to escalated mortality rates, prolonged hospitalization, and diminished quality of life (Needham, Webb, and Bryden 2017;Lyashenko, Ivanova, and Chimagomedova 2020). PND predominantly manifests as a decline in cognitive function, with detrimental impacts on memory, attention, comprehension, and information processing abilities (Tasbihgou and Absalom 2021).…”

Section: Introductionmentioning

confidence: 99%

The Efficacy and Mechanism of Kaempferol in Preventing perioperative neurocognitive disorders in the Elderly: Based on Network Pharmacology and Experimental Verification

Huang,

LI,

Han

et al. 2024

Preprint

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Objective:This research, founded on network pharmacology, molecular docking, and experimental validation, seeks to elucidate the probable therapeutic effects of Kaempferol on perioperative neurocognitive disorders，along with its operational mechanism. Methods:Key target points for the potential preventive effects of Kaempferol (Kae) on perioperative neurocognitive disorders (PND) were discerned through the Geo database and network pharmacology techniques. An animal model was established for PND through laparotomy. The model and therapeutic outcomes were verified using the Morris water maze (MWM) and Open field tests, subsequently, mechanisms of hub target regulation were confirmed through methods such as qPCR In vivo and in vitro experimental models were utilized to study the impact of Kae on microglial cell activation and inflammation, as well as Kae's rescuing effect on neuronal apoptosis, thereby exploring its neuroprotective action mechanism. Results:Network pharmacology analysis revealed that Kae could potentially exert its therapeutic effect by regulating key targets such as p-AKT1, p-JUN, PPARG, and caspase-3. These targets primarily function within inflammation and immune modulation related pathways such as the AGE-RAGE signaling pathway, TNF-α signaling pathway, and apoptosis. In vivo and in vitro model experiments demonstrated that Kae significantly influenced the activation and inflammatory response of microglial cells, indicating possible neuroprotective effects. Additionally, Kae was able to mitigate the apoptosis of primary neurons induced by LPS, a phenomenon that Kae rescues in a concentration-dependent manner. Conclusion:By regulating key targets such as p-AKT1, p-JUN, PPARG, and caspase-3, Kaempferol might play a role in the prevention and treatment of PND, demonstrating neuroprotective and cognitive function improvement effects.

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Section: Introductionmentioning

confidence: 99%

The Efficacy and Mechanism of Kaempferol in Preventing perioperative neurocognitive disorders in the Elderly: Based on Network Pharmacology and Experimental Verification

Huang,

LI,

Han

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…It affects approximately 40% of these patients, manifesting as delirium, confusion, memory loss, attention deficit, and cognitive decline. [1][2][3] These symptoms not only increase mortality and prolong hospital stays but also detrimentally impact patients' long-term quality of life. Given the growing elderly population and their frequent need for surgery, developing effective strategies for preventing and managing PND is crucial.…”

Section: Introductionmentioning

confidence: 99%

Polydopamine-Coated Kaempferol-Loaded MOF Nanoparticles: A Novel Therapeutic Strategy for Postoperative Neurocognitive Disorder

Huang,

Li,

Han

et al. 2024

IJN

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The primary objective of this study was to develop an innovative nanomedicine-based therapeutic strategy to alleviate Postoperative Neurocognitive Disorder (PND) in patients undergoing surgery. Patients and Methods: To achieve this goal, polydopamine-coated Kaempferol-loaded Metal-Organic Framework nanoparticles (pDA/ KAE@ZIF-8) were synthesized and evaluated. The study involved encapsulating Kaempferol (KAE) within ZIF-8 nanoparticles, followed by coating with polydopamine (PDA) to enhance biocompatibility and targeted delivery. The characterization of these nanoparticles (NPs) was conducted using various techniques including Scanning Electron Microscopy, Fourier-Transform Infrared Spectroscopy, X-ray Diffraction, and Ultraviolet-Visible spectroscopy. The efficacy of pDA/KAE@ZIF-8 NPs was tested in both in vitro and in vivo models, specifically focusing on their ability to penetrate the blood-brain barrier and protect neuronal cells against oxidative stress. Results: The study found that pDA/KAE@ZIF-8 NPs efficiently penetrated the blood-brain barrier and were significantly taken up by neuronal cells. These nanoparticles demonstrated remarkable Reactive Oxygen Species (ROS) scavenging capabilities and stability under physiological conditions. In vitro studies showed that pDA/KAE@ZIF-8 NPs provided protection to HT-22 neuronal cells against H 2 O 2 -induced oxidative stress, reduced the levels of pro-inflammatory cytokines, and decreased apoptosis rates. In a PND mouse model, the treatment with pDA/KAE@ZIF-8 NPs significantly improved cognitive functions, surpassing the effects of KAE alone. This improvement was substantiated through behavioral tests and a noted reduction in hippocampal inflammation. Conclusion:The findings from this study underscore the potential of pDA/KAE@ZIF-8 NPs as an effective nanotherapeutic agent for PND. This approach offers a novel direction in the postoperative care of elderly patients, with the potential to transform the therapeutic landscape for neurocognitive disorders following surgery. The application of nanotechnology in this context opens new avenues for more effective and targeted treatments, thereby improving the quality of life for patients suffering from PND.

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Impairment of cognitive functions in patients with chronic thromboembolic pulmonary hypertension before and after surgical treatment

Kamenskaya¹,

Клинкова²,

Логинова³

et al. 2023

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Postoperative cognitive disorder

Cited by 8 publications

References 50 publications

The Efficacy and Mechanism of Kaempferol in Preventing perioperative neurocognitive disorders in the Elderly: Based on Network Pharmacology and Experimental Verification

The Efficacy and Mechanism of Kaempferol in Preventing perioperative neurocognitive disorders in the Elderly: Based on Network Pharmacology and Experimental Verification

Polydopamine-Coated Kaempferol-Loaded MOF Nanoparticles: A Novel Therapeutic Strategy for Postoperative Neurocognitive Disorder

Impairment of cognitive functions in patients with chronic thromboembolic pulmonary hypertension before and after surgical treatment

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